Association between Cysticercosis and Neoplasia: A Study Based on Autopsy Findings
Chronic infections including the cysticercosis induce inflammatory cells to produce free radicals and synthesize carcinogenic toxins. The cells with genetic mutations proliferate in a disorganized manner, leading to the development of neoplasia. The aim of the present study was to demonstrate the re...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/895942 |
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| author | Camila Lourencini Cavellani Aline Cristina Souza da Silva Grace Kelly Naves de Aquino Ribeiro Lívia Ferreira Oliveira Mara Lúcia Fonseca Ferraz Vicente de Paula Antunes Teixeira |
| author_facet | Camila Lourencini Cavellani Aline Cristina Souza da Silva Grace Kelly Naves de Aquino Ribeiro Lívia Ferreira Oliveira Mara Lúcia Fonseca Ferraz Vicente de Paula Antunes Teixeira |
| author_sort | Camila Lourencini Cavellani |
| collection | DOAJ |
| description | Chronic infections including the cysticercosis induce inflammatory cells to produce free radicals and synthesize carcinogenic toxins. The cells with genetic mutations proliferate in a disorganized manner, leading to the development of neoplasia. The aim of the present study was to demonstrate the relation between cysticercosis and neoplasia. Patients autopsied were divided into 4 groups: patients with neoplasia and cysticercosis (NC), patients with neoplasia only (NN), patients with cysticercosis only (CC), and patients without neoplasia or cysticercosis (WW). Of 2012 autopsy reports analyzed, 0.4 showed NC. In groups CC and NC, the most common location of the parasite was the brain. There was a predominance of three or more cysticerci in groups NC and CC. In the NC group, all had malignant neoplasms, and was predominance of benign neoplasm in NN group. The digestive system was the most frequent neoplasia. By calculating odds ratio, rate of neoplasia in patients with cysticercosis was 0.74. In conclusion, the demographic profile of patients with cysticercosis and neoplasia is similar to that of patients with cysticercosis alone. The incidence of cysticercosis and neoplasia was greater in older patients suggesting that immunosenescence may contribute to development of neoplasia promoted by cysticercosis. |
| format | Article |
| id | doaj-art-ee6dd62ae78c4506b0264d363823ae0d |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-ee6dd62ae78c4506b0264d363823ae0d2025-02-03T01:31:13ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/895942895942Association between Cysticercosis and Neoplasia: A Study Based on Autopsy FindingsCamila Lourencini Cavellani0Aline Cristina Souza da Silva1Grace Kelly Naves de Aquino Ribeiro2Lívia Ferreira Oliveira3Mara Lúcia Fonseca Ferraz4Vicente de Paula Antunes Teixeira5Biological and Natural Science Institute, General Pathology Discipline, Triângulo Mineiro Federal University, Disciplina de Patologia Geral, Rua Frei Paulino No. 30, Bairro Abadia, 38025-180 Uberaba, MG, BrazilBiological and Natural Science Institute, General Pathology Discipline, Triângulo Mineiro Federal University, Disciplina de Patologia Geral, Rua Frei Paulino No. 30, Bairro Abadia, 38025-180 Uberaba, MG, BrazilBiological and Natural Science Institute, General Pathology Discipline, Triângulo Mineiro Federal University, Disciplina de Patologia Geral, Rua Frei Paulino No. 30, Bairro Abadia, 38025-180 Uberaba, MG, BrazilBiological and Natural Science Institute, General Pathology Discipline, Triângulo Mineiro Federal University, Disciplina de Patologia Geral, Rua Frei Paulino No. 30, Bairro Abadia, 38025-180 Uberaba, MG, BrazilBiological and Natural Science Institute, General Pathology Discipline, Triângulo Mineiro Federal University, Disciplina de Patologia Geral, Rua Frei Paulino No. 30, Bairro Abadia, 38025-180 Uberaba, MG, BrazilBiological and Natural Science Institute, General Pathology Discipline, Triângulo Mineiro Federal University, Disciplina de Patologia Geral, Rua Frei Paulino No. 30, Bairro Abadia, 38025-180 Uberaba, MG, BrazilChronic infections including the cysticercosis induce inflammatory cells to produce free radicals and synthesize carcinogenic toxins. The cells with genetic mutations proliferate in a disorganized manner, leading to the development of neoplasia. The aim of the present study was to demonstrate the relation between cysticercosis and neoplasia. Patients autopsied were divided into 4 groups: patients with neoplasia and cysticercosis (NC), patients with neoplasia only (NN), patients with cysticercosis only (CC), and patients without neoplasia or cysticercosis (WW). Of 2012 autopsy reports analyzed, 0.4 showed NC. In groups CC and NC, the most common location of the parasite was the brain. There was a predominance of three or more cysticerci in groups NC and CC. In the NC group, all had malignant neoplasms, and was predominance of benign neoplasm in NN group. The digestive system was the most frequent neoplasia. By calculating odds ratio, rate of neoplasia in patients with cysticercosis was 0.74. In conclusion, the demographic profile of patients with cysticercosis and neoplasia is similar to that of patients with cysticercosis alone. The incidence of cysticercosis and neoplasia was greater in older patients suggesting that immunosenescence may contribute to development of neoplasia promoted by cysticercosis.http://dx.doi.org/10.1155/2013/895942 |
| spellingShingle | Camila Lourencini Cavellani Aline Cristina Souza da Silva Grace Kelly Naves de Aquino Ribeiro Lívia Ferreira Oliveira Mara Lúcia Fonseca Ferraz Vicente de Paula Antunes Teixeira Association between Cysticercosis and Neoplasia: A Study Based on Autopsy Findings The Scientific World Journal |
| title | Association between Cysticercosis and Neoplasia: A Study Based on Autopsy Findings |
| title_full | Association between Cysticercosis and Neoplasia: A Study Based on Autopsy Findings |
| title_fullStr | Association between Cysticercosis and Neoplasia: A Study Based on Autopsy Findings |
| title_full_unstemmed | Association between Cysticercosis and Neoplasia: A Study Based on Autopsy Findings |
| title_short | Association between Cysticercosis and Neoplasia: A Study Based on Autopsy Findings |
| title_sort | association between cysticercosis and neoplasia a study based on autopsy findings |
| url | http://dx.doi.org/10.1155/2013/895942 |
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