Osteoarthritis and Degree of Fatigue are Associated with Pain Levels in Patients with Fibromyalgia Syndrome: A Cross-Sectional Study of 394 Patients
Zihan Wang,1,2,* Tianyi Lan,1,2,* Yuqiao Zhang,1,2 Zijia Guo,3 Hongwei Yu,4 Guiyao Sun,5 Zhitian Wang,6 Zeran Yan,1 Qingwen Tao,1 Yuan Xu1 1Traditional Chinese Medicine Department of Rheumatism, China-Japan Friendship Hospital, Beijing, People’s Republic of China; 2Graduate School, B...
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Dove Medical Press
2025-01-01
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| Series: | International Journal of General Medicine |
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| author | Wang Z Lan T Zhang Y Guo Z Yu H Sun G Wang Z Yan Z Tao Q Xu Y |
| author_facet | Wang Z Lan T Zhang Y Guo Z Yu H Sun G Wang Z Yan Z Tao Q Xu Y |
| author_sort | Wang Z |
| collection | DOAJ |
| description | Zihan Wang,1,2,* Tianyi Lan,1,2,* Yuqiao Zhang,1,2 Zijia Guo,3 Hongwei Yu,4 Guiyao Sun,5 Zhitian Wang,6 Zeran Yan,1 Qingwen Tao,1 Yuan Xu1 1Traditional Chinese Medicine Department of Rheumatism, China-Japan Friendship Hospital, Beijing, People’s Republic of China; 2Graduate School, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 3Graduate School, Inner Mongolia Medical University, Hohhot, People’s Republic of China; 4Department of Radiology, China-Japan Friendship Hospital, Beijing, People’s Republic of China; 5Department of Orthopedics, Shuangqiao Hospital, Beijing, People’s Republic of China; 6Science Faculty, University of Auckland, Auckland, New Zealand*These authors contributed equally to this workCorrespondence: Qingwen Tao; Yuan Xu, Email taoqg1@sina.com; xuyuan2004020@163.comObjective: To observe how osteoarthritis (OA) and degree of fatigue affect are associated with pain levels in patients with fibromyalgia syndrome (FMS).Methods: A cross-sectional study was conducted involving FMS patients. Data regarding the clinical features of the patients, including scores for pain-Visual Analogue Scale (VAS), Fatigue Scale-14 (FS-14) and other patient information, was collected. A multivariable logistic regression model was constructed to determine whether there is a true association between OA, degree of fatigue, and pain level in FMS patients. Restricted cubic spline (RCS) analysis was used to explore a potential non-linear relationship between degree of fatigue scores and pain levels in FMS patients. An interaction analysis based on the main regression model was performed to examine the interaction between OA and degree of fatigue.Results: Among the FMS patients, the presence of OA was identified as a risk factor associated with higher pain-VAS scores (OR=2.777, 95% CI=1.377– 5.601, P=0.004); furthermore, higher degree of fatigue scores on the FS-14 were found to be significantly associated with high pain level (OR=1.145, 95% CI=1.054– 1.243, P=0.001). The RCS analysis demonstrated a linear relationship between increasing FS-14 scores and an elevated risk of high pain levels among FMS patients (P-non-linear=0.119, P-overall=0.008). The interaction analyses revealed a significant association between OA and degree of fatigue, which were related to the pain level of patients with FMS synergistically.Conclusion: Patients with FMS experience coexisting OA and a high degree of fatigue, which interact synergistically, being correlated with increased pain levels.Trial Registration: The study was approved by the Clinical Research Ethics Committee of the China-Japan Friendship Hospital (2022-KY-079) and registered on ClinicalTrials.gov (NCT05508516) on August 17th, 2022.Keywords: fibromyalgia syndrome, osteoarthritis, fatigue, pain, correlation analysis |
| format | Article |
| id | doaj-art-ee6b0f6a91524de4a8fe129e2b2edfc4 |
| institution | Kabale University |
| issn | 1178-7074 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of General Medicine |
| spelling | doaj-art-ee6b0f6a91524de4a8fe129e2b2edfc42025-02-02T15:59:40ZengDove Medical PressInternational Journal of General Medicine1178-70742025-01-01Volume 1849750799775Osteoarthritis and Degree of Fatigue are Associated with Pain Levels in Patients with Fibromyalgia Syndrome: A Cross-Sectional Study of 394 PatientsWang ZLan TZhang YGuo ZYu HSun GWang ZYan ZTao QXu YZihan Wang,1,2,* Tianyi Lan,1,2,* Yuqiao Zhang,1,2 Zijia Guo,3 Hongwei Yu,4 Guiyao Sun,5 Zhitian Wang,6 Zeran Yan,1 Qingwen Tao,1 Yuan Xu1 1Traditional Chinese Medicine Department of Rheumatism, China-Japan Friendship Hospital, Beijing, People’s Republic of China; 2Graduate School, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 3Graduate School, Inner Mongolia Medical University, Hohhot, People’s Republic of China; 4Department of Radiology, China-Japan Friendship Hospital, Beijing, People’s Republic of China; 5Department of Orthopedics, Shuangqiao Hospital, Beijing, People’s Republic of China; 6Science Faculty, University of Auckland, Auckland, New Zealand*These authors contributed equally to this workCorrespondence: Qingwen Tao; Yuan Xu, Email taoqg1@sina.com; xuyuan2004020@163.comObjective: To observe how osteoarthritis (OA) and degree of fatigue affect are associated with pain levels in patients with fibromyalgia syndrome (FMS).Methods: A cross-sectional study was conducted involving FMS patients. Data regarding the clinical features of the patients, including scores for pain-Visual Analogue Scale (VAS), Fatigue Scale-14 (FS-14) and other patient information, was collected. A multivariable logistic regression model was constructed to determine whether there is a true association between OA, degree of fatigue, and pain level in FMS patients. Restricted cubic spline (RCS) analysis was used to explore a potential non-linear relationship between degree of fatigue scores and pain levels in FMS patients. An interaction analysis based on the main regression model was performed to examine the interaction between OA and degree of fatigue.Results: Among the FMS patients, the presence of OA was identified as a risk factor associated with higher pain-VAS scores (OR=2.777, 95% CI=1.377– 5.601, P=0.004); furthermore, higher degree of fatigue scores on the FS-14 were found to be significantly associated with high pain level (OR=1.145, 95% CI=1.054– 1.243, P=0.001). The RCS analysis demonstrated a linear relationship between increasing FS-14 scores and an elevated risk of high pain levels among FMS patients (P-non-linear=0.119, P-overall=0.008). The interaction analyses revealed a significant association between OA and degree of fatigue, which were related to the pain level of patients with FMS synergistically.Conclusion: Patients with FMS experience coexisting OA and a high degree of fatigue, which interact synergistically, being correlated with increased pain levels.Trial Registration: The study was approved by the Clinical Research Ethics Committee of the China-Japan Friendship Hospital (2022-KY-079) and registered on ClinicalTrials.gov (NCT05508516) on August 17th, 2022.Keywords: fibromyalgia syndrome, osteoarthritis, fatigue, pain, correlation analysishttps://www.dovepress.com/osteoarthritis-and-degree-of-fatigue-are-associated-with-pain-levels-i-peer-reviewed-fulltext-article-IJGMfibromyalgia syndromeosteoarthritisfatiguepaincorrelation analysis |
| spellingShingle | Wang Z Lan T Zhang Y Guo Z Yu H Sun G Wang Z Yan Z Tao Q Xu Y Osteoarthritis and Degree of Fatigue are Associated with Pain Levels in Patients with Fibromyalgia Syndrome: A Cross-Sectional Study of 394 Patients International Journal of General Medicine fibromyalgia syndrome osteoarthritis fatigue pain correlation analysis |
| title | Osteoarthritis and Degree of Fatigue are Associated with Pain Levels in Patients with Fibromyalgia Syndrome: A Cross-Sectional Study of 394 Patients |
| title_full | Osteoarthritis and Degree of Fatigue are Associated with Pain Levels in Patients with Fibromyalgia Syndrome: A Cross-Sectional Study of 394 Patients |
| title_fullStr | Osteoarthritis and Degree of Fatigue are Associated with Pain Levels in Patients with Fibromyalgia Syndrome: A Cross-Sectional Study of 394 Patients |
| title_full_unstemmed | Osteoarthritis and Degree of Fatigue are Associated with Pain Levels in Patients with Fibromyalgia Syndrome: A Cross-Sectional Study of 394 Patients |
| title_short | Osteoarthritis and Degree of Fatigue are Associated with Pain Levels in Patients with Fibromyalgia Syndrome: A Cross-Sectional Study of 394 Patients |
| title_sort | osteoarthritis and degree of fatigue are associated with pain levels in patients with fibromyalgia syndrome a cross sectional study of 394 patients |
| topic | fibromyalgia syndrome osteoarthritis fatigue pain correlation analysis |
| url | https://www.dovepress.com/osteoarthritis-and-degree-of-fatigue-are-associated-with-pain-levels-i-peer-reviewed-fulltext-article-IJGM |
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