Vascular endothelial growth factor and endocan expression in adrenal cortical tumors and their relationship with histopathological prognostic parameters
The aim of this study was to determine the tissue expressions of vascular endothelial growth factor (VEGF) and endocan in adrenal cortical tumors and the factors associated with them. The study included 6 subjects with adrenocortical adenoma (ACA), 7 subjects with adrenocortical carcinoma (ACC), and...
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The Japan Endocrine Society
2024-08-01
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| Series: | Endocrine Journal |
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| Online Access: | https://www.jstage.jst.go.jp/article/endocrj/71/8/71_EJ24-0032/_html/-char/en |
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| author | Melia Karaköse Mustafa Can Muhammet Kocabaş Hacı Hasan Esen Mustafa Kulaksızoğlu Feridun Karakurt |
| author_facet | Melia Karaköse Mustafa Can Muhammet Kocabaş Hacı Hasan Esen Mustafa Kulaksızoğlu Feridun Karakurt |
| author_sort | Melia Karaköse |
| collection | DOAJ |
| description | The aim of this study was to determine the tissue expressions of vascular endothelial growth factor (VEGF) and endocan in adrenal cortical tumors and the factors associated with them. The study included 6 subjects with adrenocortical adenoma (ACA), 7 subjects with adrenocortical carcinoma (ACC), and 13 control subjects with a normal adrenal cortex. The status of VEGF and endocan expression was determined by the proportions of cells staining on a scale ranging from negative (not staining at all) to strongly positive. VEGF expression was detected in 1 (16.7%) of 6 subjects in the ACA group and in 6 (85.7%) of 7 subjects in the ACC group. VEGF expression was not detected in any of the subjects in the control group. Endocan expression was detected in 6 (100%) of 6 subjects in the ACA group and in 7 (100%) of 7 subjects in the ACC group, while it was detected in only 4 (30.7%) of 13 subjects in the control group. VEGF was expressed with a high frequency in subjects with ACC and with a low frequency in subjects with ACA, but it was not expressed in subjects with normal adrenal cortex tissue. Although endocan was expressed with a higher frequency in subjects with ACC and ACA, it was also expressed in subjects with normal adrenal cortex tissue. The percentage of cells expressed endocan in subjects with ACC was also significantly higher than in subjects with both ACA and normal adrenal cortex. |
| format | Article |
| id | doaj-art-ee68ad59729747d98d1f5b9280579d76 |
| institution | Kabale University |
| issn | 1348-4540 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | The Japan Endocrine Society |
| record_format | Article |
| series | Endocrine Journal |
| spelling | doaj-art-ee68ad59729747d98d1f5b9280579d762025-01-22T05:14:15ZengThe Japan Endocrine SocietyEndocrine Journal1348-45402024-08-0171878979710.1507/endocrj.EJ24-0032endocrjVascular endothelial growth factor and endocan expression in adrenal cortical tumors and their relationship with histopathological prognostic parametersMelia Karaköse0Mustafa Can1Muhammet Kocabaş2Hacı Hasan Esen3Mustafa Kulaksızoğlu4Feridun Karakurt5Division of Endocrinology and Metabolism, Department of Internal Medicine, Meram School of Medicine, Necmettin Erbakan University, Konya 42000, TurkeyDivision of Endocrinology and Metabolism, Department of Internal Medicine, Muş State Hospital, Muş 49100, TurkeyDivision of Endocrinology and Metabolism, Department of Internal Medicine, Meram School of Medicine, Necmettin Erbakan University, Konya 42000, TurkeyDepartment of Pathology, Meram School of Medicine, Necmettin Erbakan University, Konya 42000, TurkeyDivision of Endocrinology and Metabolism, Department of Internal Medicine, Meram School of Medicine, Necmettin Erbakan University, Konya 42000, TurkeyDivision of Endocrinology and Metabolism, Department of Internal Medicine, Meram School of Medicine, Necmettin Erbakan University, Konya 42000, TurkeyThe aim of this study was to determine the tissue expressions of vascular endothelial growth factor (VEGF) and endocan in adrenal cortical tumors and the factors associated with them. The study included 6 subjects with adrenocortical adenoma (ACA), 7 subjects with adrenocortical carcinoma (ACC), and 13 control subjects with a normal adrenal cortex. The status of VEGF and endocan expression was determined by the proportions of cells staining on a scale ranging from negative (not staining at all) to strongly positive. VEGF expression was detected in 1 (16.7%) of 6 subjects in the ACA group and in 6 (85.7%) of 7 subjects in the ACC group. VEGF expression was not detected in any of the subjects in the control group. Endocan expression was detected in 6 (100%) of 6 subjects in the ACA group and in 7 (100%) of 7 subjects in the ACC group, while it was detected in only 4 (30.7%) of 13 subjects in the control group. VEGF was expressed with a high frequency in subjects with ACC and with a low frequency in subjects with ACA, but it was not expressed in subjects with normal adrenal cortex tissue. Although endocan was expressed with a higher frequency in subjects with ACC and ACA, it was also expressed in subjects with normal adrenal cortex tissue. The percentage of cells expressed endocan in subjects with ACC was also significantly higher than in subjects with both ACA and normal adrenal cortex.https://www.jstage.jst.go.jp/article/endocrj/71/8/71_EJ24-0032/_html/-char/enadrenal cortical tumorvascular endothelial growth factorendocan |
| spellingShingle | Melia Karaköse Mustafa Can Muhammet Kocabaş Hacı Hasan Esen Mustafa Kulaksızoğlu Feridun Karakurt Vascular endothelial growth factor and endocan expression in adrenal cortical tumors and their relationship with histopathological prognostic parameters Endocrine Journal adrenal cortical tumor vascular endothelial growth factor endocan |
| title | Vascular endothelial growth factor and endocan expression in adrenal cortical tumors and their relationship with histopathological prognostic parameters |
| title_full | Vascular endothelial growth factor and endocan expression in adrenal cortical tumors and their relationship with histopathological prognostic parameters |
| title_fullStr | Vascular endothelial growth factor and endocan expression in adrenal cortical tumors and their relationship with histopathological prognostic parameters |
| title_full_unstemmed | Vascular endothelial growth factor and endocan expression in adrenal cortical tumors and their relationship with histopathological prognostic parameters |
| title_short | Vascular endothelial growth factor and endocan expression in adrenal cortical tumors and their relationship with histopathological prognostic parameters |
| title_sort | vascular endothelial growth factor and endocan expression in adrenal cortical tumors and their relationship with histopathological prognostic parameters |
| topic | adrenal cortical tumor vascular endothelial growth factor endocan |
| url | https://www.jstage.jst.go.jp/article/endocrj/71/8/71_EJ24-0032/_html/-char/en |
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