Palmitoylation prevents B7-H4 lysosomal degradation sustaining tumor immune evasion

Palmitoylation prevents B7-H4 lysosomal degradation sustaining tumor immune evasion

Abstract B7-H4 functions as an immune checkpoint in the tumor microenvironment (TME). However, the post-translational modification (PTM) of B7-H4 and its translational potential in cancer remains incompletely understood. We find that ZDHHC3, a zinc finger DHHC-type palmitoyltransferase, palmitoylate...

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Main Authors: Yijian Yan, Jiali Yu, Weichao Wang, Ying Xu, Kole Tison, Rongxin Xiao, Sara Grove, Shuang Wei, Linda Vatan, Max Wicha, Ilona Kryczek, Weiping Zou
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58552-5
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