Development of patient-specific iPSC-based epilepsy models and identification of differentially expressed genes for disease mechanisms

Development of patient-specific iPSC-based epilepsy models and identification of differentially expressed genes for disease mechanisms

IntroductionEpilepsy is a complex neurodegenerative disorder characterized by recurrent seizures, which poses significant challenges for clinical management and therapeutic development. Recent advances in stem cell biology have enabled the use of patient-specific induced pluripotent stem cells (iPSC...

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Main Authors: Jianfeng Wu, Siqi Huang, Lihao Chen, Yinghong Yang, Shunhan Zhang, Jiajia Xian, Xiaoyan Ma, Furong Ma, Shaoying Li, Yi Yang, Yingjun Xie, Xiaofang Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Neuroscience
Subjects:
epilepsy
induced pluripotent stem cells (iPSCs)
RNA sequencing
disease modeling
personalized medicine
gene expression analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2025.1582255/full
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