Synthesis, Characterization, and Crystal Structures of Bis-Imidazolium Salts and Respective Dinuclear Ag(I) N-Heterocyclic Carbene Complexes: In Vitro Anticancer Studies against “Human Colon Cancer” and “Breast Cancer”
This paper describes synthesis, characterization (NMR, FT-IR, microanalysis, and X-ray crystallography), in vitro anticancer activity of ortho/para-xylyl linked bis-imidazolium salts (4-5) and respective dinuclear Ag(I) N-heterocyclic carbene (NHC) complexes (6-7). All the compounds were tested for...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2013/804683 |
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| author | Rosenani A. Haque Siti Fatimah Nasri Muhammad Adnan Iqbal Sawsan S. Al-Rawi Seyedeh Fatemeh Jafari Mohamed B. Khadeer Ahamed A. M. S. Abdul Majid |
| author_facet | Rosenani A. Haque Siti Fatimah Nasri Muhammad Adnan Iqbal Sawsan S. Al-Rawi Seyedeh Fatemeh Jafari Mohamed B. Khadeer Ahamed A. M. S. Abdul Majid |
| author_sort | Rosenani A. Haque |
| collection | DOAJ |
| description | This paper describes synthesis, characterization (NMR, FT-IR, microanalysis, and X-ray crystallography), in vitro anticancer activity of ortho/para-xylyl linked bis-imidazolium salts (4-5) and respective dinuclear Ag(I) N-heterocyclic carbene (NHC) complexes (6-7). All the compounds were tested for their cytotoxicity against human colorectal cancer (HCT 116) and breast cancer (MCF-7) cell lines. According to cell viability measurements using MTT assay, all the complexes (6-7) showed a dose-dependent cytotoxic activity against both the cell lines, whereas respective salts (4-5) proved to be inactive. The complexes (6-7) demonstrated significant activity with IC50 values range 5.6–20.3 μM for HCT 116 and 1.12–6.38 μM for MCF-7. 5-Fluorouracil was used as standard drug (IC50 = 5.9 μM) for HCT 116, whereas tamoxifen was used as standard drug for MCF-7 (IC50 = 14 μM) cell line. |
| format | Article |
| id | doaj-art-ee58a36d7a9440b59f2d9c3a47a43d59 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-ee58a36d7a9440b59f2d9c3a47a43d592025-02-03T01:30:38ZengWileyJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/804683804683Synthesis, Characterization, and Crystal Structures of Bis-Imidazolium Salts and Respective Dinuclear Ag(I) N-Heterocyclic Carbene Complexes: In Vitro Anticancer Studies against “Human Colon Cancer” and “Breast Cancer”Rosenani A. Haque0Siti Fatimah Nasri1Muhammad Adnan Iqbal2Sawsan S. Al-Rawi3Seyedeh Fatemeh Jafari4Mohamed B. Khadeer Ahamed5A. M. S. Abdul Majid6The School of Chemical Sciences, Universiti Sains Malaysia (USM), 11800 Penang, MalaysiaThe School of Chemical Sciences, Universiti Sains Malaysia (USM), 11800 Penang, MalaysiaThe School of Chemical Sciences, Universiti Sains Malaysia (USM), 11800 Penang, MalaysiaEMAN Research and Testing Laboratory, The School of Pharmaceutical Sciences, Universiti Sains Malaysia (USM), 11800 Penang, MalaysiaEMAN Research and Testing Laboratory, The School of Pharmaceutical Sciences, Universiti Sains Malaysia (USM), 11800 Penang, MalaysiaEMAN Research and Testing Laboratory, The School of Pharmaceutical Sciences, Universiti Sains Malaysia (USM), 11800 Penang, MalaysiaEMAN Research and Testing Laboratory, The School of Pharmaceutical Sciences, Universiti Sains Malaysia (USM), 11800 Penang, MalaysiaThis paper describes synthesis, characterization (NMR, FT-IR, microanalysis, and X-ray crystallography), in vitro anticancer activity of ortho/para-xylyl linked bis-imidazolium salts (4-5) and respective dinuclear Ag(I) N-heterocyclic carbene (NHC) complexes (6-7). All the compounds were tested for their cytotoxicity against human colorectal cancer (HCT 116) and breast cancer (MCF-7) cell lines. According to cell viability measurements using MTT assay, all the complexes (6-7) showed a dose-dependent cytotoxic activity against both the cell lines, whereas respective salts (4-5) proved to be inactive. The complexes (6-7) demonstrated significant activity with IC50 values range 5.6–20.3 μM for HCT 116 and 1.12–6.38 μM for MCF-7. 5-Fluorouracil was used as standard drug (IC50 = 5.9 μM) for HCT 116, whereas tamoxifen was used as standard drug for MCF-7 (IC50 = 14 μM) cell line.http://dx.doi.org/10.1155/2013/804683 |
| spellingShingle | Rosenani A. Haque Siti Fatimah Nasri Muhammad Adnan Iqbal Sawsan S. Al-Rawi Seyedeh Fatemeh Jafari Mohamed B. Khadeer Ahamed A. M. S. Abdul Majid Synthesis, Characterization, and Crystal Structures of Bis-Imidazolium Salts and Respective Dinuclear Ag(I) N-Heterocyclic Carbene Complexes: In Vitro Anticancer Studies against “Human Colon Cancer” and “Breast Cancer” Journal of Chemistry |
| title | Synthesis, Characterization, and Crystal Structures of Bis-Imidazolium Salts and Respective Dinuclear Ag(I) N-Heterocyclic Carbene Complexes: In Vitro Anticancer Studies against “Human Colon Cancer” and “Breast Cancer” |
| title_full | Synthesis, Characterization, and Crystal Structures of Bis-Imidazolium Salts and Respective Dinuclear Ag(I) N-Heterocyclic Carbene Complexes: In Vitro Anticancer Studies against “Human Colon Cancer” and “Breast Cancer” |
| title_fullStr | Synthesis, Characterization, and Crystal Structures of Bis-Imidazolium Salts and Respective Dinuclear Ag(I) N-Heterocyclic Carbene Complexes: In Vitro Anticancer Studies against “Human Colon Cancer” and “Breast Cancer” |
| title_full_unstemmed | Synthesis, Characterization, and Crystal Structures of Bis-Imidazolium Salts and Respective Dinuclear Ag(I) N-Heterocyclic Carbene Complexes: In Vitro Anticancer Studies against “Human Colon Cancer” and “Breast Cancer” |
| title_short | Synthesis, Characterization, and Crystal Structures of Bis-Imidazolium Salts and Respective Dinuclear Ag(I) N-Heterocyclic Carbene Complexes: In Vitro Anticancer Studies against “Human Colon Cancer” and “Breast Cancer” |
| title_sort | synthesis characterization and crystal structures of bis imidazolium salts and respective dinuclear ag i n heterocyclic carbene complexes in vitro anticancer studies against human colon cancer and breast cancer |
| url | http://dx.doi.org/10.1155/2013/804683 |
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