Recurrent Posterior Strokes in Inflammatory Bowel Disease Patients
Objective. To describe the stroke characteristics of patients with a history of inflammatory bowel disease (IBD). Background. A hypercoagulable state associated with IBD has been frequently implicated as a risk factor for ischemic stroke. Variable mechanisms and infrequent occurrence limit prospecti...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2015/672460 |
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| _version_ | 1849692360353513472 |
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| author | Amir Shaban Brett Hymel Maria Chavez-Keatts Jordan J. Karlitz Sheryl Martin-Schild |
| author_facet | Amir Shaban Brett Hymel Maria Chavez-Keatts Jordan J. Karlitz Sheryl Martin-Schild |
| author_sort | Amir Shaban |
| collection | DOAJ |
| description | Objective. To describe the stroke characteristics of patients with a history of inflammatory bowel disease (IBD). Background. A hypercoagulable state associated with IBD has been frequently implicated as a risk factor for ischemic stroke. Variable mechanisms and infrequent occurrence limit prospective clinical research on the association between IBD and stroke. Methods. We retrospectively reviewed consecutive patients with acute ischemic stroke presenting to our medical center from 7/2008 to 9/2013. Patients with a history of IBD were identified. Clinical variables were abstracted from our prospective stroke registry. Results. Over the period of five years we identified only three patients with a documented history of IBD. Each of these patients presented three times to our hospital with new strokes. Patients presented outside the window for intravenous tPA treatment on 8/9 admissions. Each one of our patients had posterior strokes on at least two separate occasions. Hypercoagulation panel showed elevated factor VIII with or without concomitant elevation of Von Willebrand factor (vWF) during almost every admission (8/9 admissions). Only one admission was associated with IBD flare. Conclusion. The association between IBD and posterior strokes is a novel finding. Factor VIII elevation may serve as a biomarker of a peristroke hypercoagulable state in patients with IBD. |
| format | Article |
| id | doaj-art-ee48f6d0581f4e13ba10de29534b8ba0 |
| institution | DOAJ |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-ee48f6d0581f4e13ba10de29534b8ba02025-08-20T03:20:43ZengWileyGastroenterology Research and Practice1687-61211687-630X2015-01-01201510.1155/2015/672460672460Recurrent Posterior Strokes in Inflammatory Bowel Disease PatientsAmir Shaban0Brett Hymel1Maria Chavez-Keatts2Jordan J. Karlitz3Sheryl Martin-Schild4Department of Neurology, University of Iowa, Iowa City, USADepartment of Gastroenterology, Louisiana State University Health Sciences Center New Orleans, New Orleans, USADepartment of Neurology, Louisiana State University Health Sciences Center New Orleans, New Orleans, USADepartment of Internal Medicine, Section of Gastroenterology, Tulane University School of Medicine, New Orleans, USADepartment of Neurology, Tulane University School of Medicine, New Orleans, USAObjective. To describe the stroke characteristics of patients with a history of inflammatory bowel disease (IBD). Background. A hypercoagulable state associated with IBD has been frequently implicated as a risk factor for ischemic stroke. Variable mechanisms and infrequent occurrence limit prospective clinical research on the association between IBD and stroke. Methods. We retrospectively reviewed consecutive patients with acute ischemic stroke presenting to our medical center from 7/2008 to 9/2013. Patients with a history of IBD were identified. Clinical variables were abstracted from our prospective stroke registry. Results. Over the period of five years we identified only three patients with a documented history of IBD. Each of these patients presented three times to our hospital with new strokes. Patients presented outside the window for intravenous tPA treatment on 8/9 admissions. Each one of our patients had posterior strokes on at least two separate occasions. Hypercoagulation panel showed elevated factor VIII with or without concomitant elevation of Von Willebrand factor (vWF) during almost every admission (8/9 admissions). Only one admission was associated with IBD flare. Conclusion. The association between IBD and posterior strokes is a novel finding. Factor VIII elevation may serve as a biomarker of a peristroke hypercoagulable state in patients with IBD.http://dx.doi.org/10.1155/2015/672460 |
| spellingShingle | Amir Shaban Brett Hymel Maria Chavez-Keatts Jordan J. Karlitz Sheryl Martin-Schild Recurrent Posterior Strokes in Inflammatory Bowel Disease Patients Gastroenterology Research and Practice |
| title | Recurrent Posterior Strokes in Inflammatory Bowel Disease Patients |
| title_full | Recurrent Posterior Strokes in Inflammatory Bowel Disease Patients |
| title_fullStr | Recurrent Posterior Strokes in Inflammatory Bowel Disease Patients |
| title_full_unstemmed | Recurrent Posterior Strokes in Inflammatory Bowel Disease Patients |
| title_short | Recurrent Posterior Strokes in Inflammatory Bowel Disease Patients |
| title_sort | recurrent posterior strokes in inflammatory bowel disease patients |
| url | http://dx.doi.org/10.1155/2015/672460 |
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