Neuroinflammation Induced by Surgery Does Not Impair the Reference Memory of Young Adult Mice
Postoperative cognitive dysfunction (POCD) increases morbidity and mortality after surgery. But the underlying mechanism is not clear yet. While age is now accepted as the top one risk factor for POCD, results from studies investigating postoperative cognitive functions in adults have been controver...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/3271579 |
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| _version_ | 1832558214293487616 |
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| author | Yanhua Zhao Lili Huang Huan Xu Guangxi Wu Mengyi Zhu Jie Tian Hao Wang Xiangrui Wang Weifeng Yu Liqun Yang Diansan Su |
| author_facet | Yanhua Zhao Lili Huang Huan Xu Guangxi Wu Mengyi Zhu Jie Tian Hao Wang Xiangrui Wang Weifeng Yu Liqun Yang Diansan Su |
| author_sort | Yanhua Zhao |
| collection | DOAJ |
| description | Postoperative cognitive dysfunction (POCD) increases morbidity and mortality after surgery. But the underlying mechanism is not clear yet. While age is now accepted as the top one risk factor for POCD, results from studies investigating postoperative cognitive functions in adults have been controversial, and data about the very young adult individuals are lacking. The present study investigated the spatial reference memory, IL-1β, IL-6, and microglia activation changes in the hippocampus in 2-month-old mice after anesthesia and surgery. We found that hippocampal IL-1β and IL-6 increased at 6 hours after surgery. Microglia were profoundly activated in the hippocampus 6 to 24 hours after surgery. However, no significant behavior changes were found in these mice. These results indicate that although anesthesia and surgery led to neuroinflammation, the latter was insufficient to impair the spatial reference memory of young adult mice. |
| format | Article |
| id | doaj-art-ee484b2890b64dd088e13a2c8a75ddaa |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-ee484b2890b64dd088e13a2c8a75ddaa2025-02-03T01:32:58ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/32715793271579Neuroinflammation Induced by Surgery Does Not Impair the Reference Memory of Young Adult MiceYanhua Zhao0Lili Huang1Huan Xu2Guangxi Wu3Mengyi Zhu4Jie Tian5Hao Wang6Xiangrui Wang7Weifeng Yu8Liqun Yang9Diansan Su10Department of Anesthesiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaDepartment of Anesthesiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaDepartment of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Anesthesiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaDepartment of Anesthesiology, Shanghai Tenth People’s Hospital, Shanghai, ChinaDepartment of Anesthesiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaShanghai Universities Collaborative Innovation Center for Translational Medicine, Shanghai, ChinaDepartment of Anesthesiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaDepartment of Anesthesiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaDepartment of Anesthesiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaDepartment of Anesthesiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaPostoperative cognitive dysfunction (POCD) increases morbidity and mortality after surgery. But the underlying mechanism is not clear yet. While age is now accepted as the top one risk factor for POCD, results from studies investigating postoperative cognitive functions in adults have been controversial, and data about the very young adult individuals are lacking. The present study investigated the spatial reference memory, IL-1β, IL-6, and microglia activation changes in the hippocampus in 2-month-old mice after anesthesia and surgery. We found that hippocampal IL-1β and IL-6 increased at 6 hours after surgery. Microglia were profoundly activated in the hippocampus 6 to 24 hours after surgery. However, no significant behavior changes were found in these mice. These results indicate that although anesthesia and surgery led to neuroinflammation, the latter was insufficient to impair the spatial reference memory of young adult mice.http://dx.doi.org/10.1155/2016/3271579 |
| spellingShingle | Yanhua Zhao Lili Huang Huan Xu Guangxi Wu Mengyi Zhu Jie Tian Hao Wang Xiangrui Wang Weifeng Yu Liqun Yang Diansan Su Neuroinflammation Induced by Surgery Does Not Impair the Reference Memory of Young Adult Mice Mediators of Inflammation |
| title | Neuroinflammation Induced by Surgery Does Not Impair the Reference Memory of Young Adult Mice |
| title_full | Neuroinflammation Induced by Surgery Does Not Impair the Reference Memory of Young Adult Mice |
| title_fullStr | Neuroinflammation Induced by Surgery Does Not Impair the Reference Memory of Young Adult Mice |
| title_full_unstemmed | Neuroinflammation Induced by Surgery Does Not Impair the Reference Memory of Young Adult Mice |
| title_short | Neuroinflammation Induced by Surgery Does Not Impair the Reference Memory of Young Adult Mice |
| title_sort | neuroinflammation induced by surgery does not impair the reference memory of young adult mice |
| url | http://dx.doi.org/10.1155/2016/3271579 |
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