Bronchiolitis Severity Affects Blood Count and Inflammatory Marker Levels: A Real-Life Experience
Background: Bronchiolitis is the most common cause of lower respiratory tract infection (LRTI) in the first year of life. We analyzed the association between complete blood count (CBC), c-reactive protein (CRP), and novel inflammatory indexes (NLR, PLR, MLR, ELR, LMR, NPR, LPR, LNR, PNR, SII, SIRI)...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/17/1/77 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832587325409853440 |
|---|---|
| author | Antonella Gambadauro Salvatore Mollica Emanuela Rosa Federica Xerra Alessandra Li Pomi Mariella Valenzise Maria Francesca Messina Agata Vitale Eloisa Gitto Malgorzata Wasniewska Giuseppina Zirilli Sara Manti |
| author_facet | Antonella Gambadauro Salvatore Mollica Emanuela Rosa Federica Xerra Alessandra Li Pomi Mariella Valenzise Maria Francesca Messina Agata Vitale Eloisa Gitto Malgorzata Wasniewska Giuseppina Zirilli Sara Manti |
| author_sort | Antonella Gambadauro |
| collection | DOAJ |
| description | Background: Bronchiolitis is the most common cause of lower respiratory tract infection (LRTI) in the first year of life. We analyzed the association between complete blood count (CBC), c-reactive protein (CRP), and novel inflammatory indexes (NLR, PLR, MLR, ELR, LMR, NPR, LPR, LNR, PNR, SII, SIRI) in predicting bronchiolitis severity at hospital admission. Methods: We retrospectively collected data from 95 infants hospitalized for bronchiolitis in a third-level hospital during three epidemic seasons. Five outcomes of severity were analyzed: BRAS; pediatric intensive care unit (PICU) admission; ventilatory support; intravenous (IV) rehydration; and length of stay (LOS). Results: Lower age and weight at admission were statistically associated with four of the five severity outcomes. Prolonged LOS (≥6 days) was associated with high values of total white blood cells, lymphocytes, and eosinophils. Only three inflammatory indexes (PLR, MLR, and PNR) showed a significant association with one outcome (prolonged LOS). A new index (RBC/AiW/1000) was statistically associated with each severity outcome for a value > 350. Conclusions: We proposed a comprehensive analysis of the association between CBC, CRP, and novel inflammatory indexes and bronchiolitis severity. RBC/AiW/1000 could represent a future predictive marker of disease severity at hospital admission in infants with bronchiolitis. |
| format | Article |
| id | doaj-art-ee3ba962382145738e0be57ba8fd39a5 |
| institution | Kabale University |
| issn | 1999-4915 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj-art-ee3ba962382145738e0be57ba8fd39a52025-01-24T13:52:30ZengMDPI AGViruses1999-49152025-01-011717710.3390/v17010077Bronchiolitis Severity Affects Blood Count and Inflammatory Marker Levels: A Real-Life ExperienceAntonella Gambadauro0Salvatore Mollica1Emanuela Rosa2Federica Xerra3Alessandra Li Pomi4Mariella Valenzise5Maria Francesca Messina6Agata Vitale7Eloisa Gitto8Malgorzata Wasniewska9Giuseppina Zirilli10Sara Manti11Pediatric Unit, Department of Human Pathology in Adult and Developmental Age “Gaetano Barresi”, University of Messina, Via Consolare Valeria 1, 98124 Messina, ItalyPediatric Unit, Department of Human Pathology in Adult and Developmental Age “Gaetano Barresi”, University of Messina, Via Consolare Valeria 1, 98124 Messina, ItalyFaculty of Medicine and Surgery, University of Messina, Piazza Pugliatti 1, 98122 Messina, ItalyPediatric Unit, Department of Human Pathology in Adult and Developmental Age “Gaetano Barresi”, University of Messina, Via Consolare Valeria 1, 98124 Messina, ItalyPediatric Unit, Department of Human Pathology in Adult and Developmental Age “Gaetano Barresi”, University of Messina, Via Consolare Valeria 1, 98124 Messina, ItalyPediatric Unit, Department of Human Pathology in Adult and Developmental Age “Gaetano Barresi”, University of Messina, Via Consolare Valeria 1, 98124 Messina, ItalyPediatric Unit, Department of Human Pathology in Adult and Developmental Age “Gaetano Barresi”, University of Messina, Via Consolare Valeria 1, 98124 Messina, ItalyPediatric Unit, Department of Human Pathology in Adult and Developmental Age “Gaetano Barresi”, University of Messina, Via Consolare Valeria 1, 98124 Messina, ItalyNeonatal and Pediatric Intensive Care Unit, Department of Human Pathology in Adult and Developmental Age “Gaetano Barresi”, University of Messina, Via Consolare Valeria 1, 98124 Messina, ItalyPediatric Unit, Department of Human Pathology in Adult and Developmental Age “Gaetano Barresi”, University of Messina, Via Consolare Valeria 1, 98124 Messina, ItalyPediatric Unit, Department of Human Pathology in Adult and Developmental Age “Gaetano Barresi”, University of Messina, Via Consolare Valeria 1, 98124 Messina, ItalyPediatric Unit, Department of Human Pathology in Adult and Developmental Age “Gaetano Barresi”, University of Messina, Via Consolare Valeria 1, 98124 Messina, ItalyBackground: Bronchiolitis is the most common cause of lower respiratory tract infection (LRTI) in the first year of life. We analyzed the association between complete blood count (CBC), c-reactive protein (CRP), and novel inflammatory indexes (NLR, PLR, MLR, ELR, LMR, NPR, LPR, LNR, PNR, SII, SIRI) in predicting bronchiolitis severity at hospital admission. Methods: We retrospectively collected data from 95 infants hospitalized for bronchiolitis in a third-level hospital during three epidemic seasons. Five outcomes of severity were analyzed: BRAS; pediatric intensive care unit (PICU) admission; ventilatory support; intravenous (IV) rehydration; and length of stay (LOS). Results: Lower age and weight at admission were statistically associated with four of the five severity outcomes. Prolonged LOS (≥6 days) was associated with high values of total white blood cells, lymphocytes, and eosinophils. Only three inflammatory indexes (PLR, MLR, and PNR) showed a significant association with one outcome (prolonged LOS). A new index (RBC/AiW/1000) was statistically associated with each severity outcome for a value > 350. Conclusions: We proposed a comprehensive analysis of the association between CBC, CRP, and novel inflammatory indexes and bronchiolitis severity. RBC/AiW/1000 could represent a future predictive marker of disease severity at hospital admission in infants with bronchiolitis.https://www.mdpi.com/1999-4915/17/1/77bronchiolitisinflammationseverity scorepediatric intensive care unitinfants |
| spellingShingle | Antonella Gambadauro Salvatore Mollica Emanuela Rosa Federica Xerra Alessandra Li Pomi Mariella Valenzise Maria Francesca Messina Agata Vitale Eloisa Gitto Malgorzata Wasniewska Giuseppina Zirilli Sara Manti Bronchiolitis Severity Affects Blood Count and Inflammatory Marker Levels: A Real-Life Experience Viruses bronchiolitis inflammation severity score pediatric intensive care unit infants |
| title | Bronchiolitis Severity Affects Blood Count and Inflammatory Marker Levels: A Real-Life Experience |
| title_full | Bronchiolitis Severity Affects Blood Count and Inflammatory Marker Levels: A Real-Life Experience |
| title_fullStr | Bronchiolitis Severity Affects Blood Count and Inflammatory Marker Levels: A Real-Life Experience |
| title_full_unstemmed | Bronchiolitis Severity Affects Blood Count and Inflammatory Marker Levels: A Real-Life Experience |
| title_short | Bronchiolitis Severity Affects Blood Count and Inflammatory Marker Levels: A Real-Life Experience |
| title_sort | bronchiolitis severity affects blood count and inflammatory marker levels a real life experience |
| topic | bronchiolitis inflammation severity score pediatric intensive care unit infants |
| url | https://www.mdpi.com/1999-4915/17/1/77 |
| work_keys_str_mv | AT antonellagambadauro bronchiolitisseverityaffectsbloodcountandinflammatorymarkerlevelsareallifeexperience AT salvatoremollica bronchiolitisseverityaffectsbloodcountandinflammatorymarkerlevelsareallifeexperience AT emanuelarosa bronchiolitisseverityaffectsbloodcountandinflammatorymarkerlevelsareallifeexperience AT federicaxerra bronchiolitisseverityaffectsbloodcountandinflammatorymarkerlevelsareallifeexperience AT alessandralipomi bronchiolitisseverityaffectsbloodcountandinflammatorymarkerlevelsareallifeexperience AT mariellavalenzise bronchiolitisseverityaffectsbloodcountandinflammatorymarkerlevelsareallifeexperience AT mariafrancescamessina bronchiolitisseverityaffectsbloodcountandinflammatorymarkerlevelsareallifeexperience AT agatavitale bronchiolitisseverityaffectsbloodcountandinflammatorymarkerlevelsareallifeexperience AT eloisagitto bronchiolitisseverityaffectsbloodcountandinflammatorymarkerlevelsareallifeexperience AT malgorzatawasniewska bronchiolitisseverityaffectsbloodcountandinflammatorymarkerlevelsareallifeexperience AT giuseppinazirilli bronchiolitisseverityaffectsbloodcountandinflammatorymarkerlevelsareallifeexperience AT saramanti bronchiolitisseverityaffectsbloodcountandinflammatorymarkerlevelsareallifeexperience |