Association of Methylenetetrahydrofolate Reductase C677T Gene Polymorphisms with Mild Cognitive Impairment Susceptibility: A Systematic Review and Meta-Analysis

Association of Methylenetetrahydrofolate Reductase C677T Gene Polymorphisms with Mild Cognitive Impairment Susceptibility: A Systematic Review and Meta-Analysis

Background. Methylenetetrahydrofolate reductase (MTHFR) C677T (rs1801133) gene polymorphisms are related to a growing risk of Alzheimer’s disease; however, whether this association applies to mild cognitive impairment (MCI) remains unclear. Objective. We conducted this meta-analysis to evaluate the...

Full description

Saved in:

Bibliographic Details
Main Authors:	Jiahui Sun, Xuefan Jiang, Ming Zhao, Lina Ma, Hui Pei, Nanyang Liu, Hao Li
Format:	Article
Language:	English
Published:	Wiley 2021-01-01
Series:	Behavioural Neurology
Online Access:	http://dx.doi.org/10.1155/2021/2962792
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Meta Analysis of Methylenetetrahydrofolate Reductase (MTHFR) C677T polymorphism and its association with folate and colorectal cancer
by: Meng Ye, et al.
Published: (2025-01-01)

Lack of Association of C677T Methylenetetrahydrofolate Reductase Polymorphism with Breast Cancer Risk in Mali
by: Brehima Diakite, et al.
Published: (2023-01-01)

Priapism in a Child from Homocystinuria from Methylenetetrahydrofolate Reductase MTHFR (C677T) Mutation
by: Ameer Kakaje, et al.
Published: (2023-01-01)

5,10-methylenetetrahydrofolate reductase C677T gene polymorphism as a risk factor for premature coronary artery disease in patients with type 2 diabetes mellitus
by: Nisreen O. Mohammed, et al.
Published: (2025-01-01)

Role of Prothrombin and Methylenetetrahydrofolate Reductase Gene Polymorphisms as well as Thrombophilia Markers, as Risk Factors for Unexplained Recurrent Miscarriage: A Case-Control Study
by: Zeinab Ahmed Abd Elhameed, et al.
Published: (2025-01-01)

Methylenetetrahydrofolate reductase gene polymorphisms, lipid profiles, and basic renal functional markers as risk for myocardial infarction: A case-control study and haplotype analysis
by: Perović Svetlana, et al.
Published: (2024-01-01)

Methylenetetrahydrofolate Reductase Enzyme Mutations and Relationship of Homocysteine Vitamin B12 and Folate Blood Levels
by: Tuba Günebak Şahin, et al.
Published: (2013-04-01)

Evaluating the Association Between Methylenetetrahydrofolate Reductase (Rs1801131 and Rs1801133) Gene Polymorphisms and Severity of Coronary Lesions in Patients With STEMI and NSTEMI: A Retrospective Cross‐Sectional Study
by: Behnam Nazarzadeh, et al.
Published: (2025-01-01)

Hyperbaric Oxygen Therapy in Branch Retinal Artery Occlusion in a 15-Year-Old Boy with Methylenetetrahydrofolate Reductase Mutation
by: Ali Riza Cenk Celebi, et al.
Published: (2015-01-01)

Cognitive profile in mild cognitive impairment with Lewy bodies
by: Shuai Liu, et al.
Published: (2023-08-01)

Polymorphism of MTHFR C677T Gene and the Associations with the Severity of Essential Hypertension in Northern Chinese Population
by: Junli Song, et al.
Published: (2020-01-01)

Retraction: Associations of vitamin D receptor polymorphisms with risk of Alzheimer's disease, Parkinson's disease, and mild cognitive impairment: a systematic review and meta-analysis
by: Frontiers Editorial Office
Published: (2025-01-01)

Neuropsychiatric symptoms and specific cognitive domains in mild cognitive impairment
by: Lucas Luchesi Barnes, et al.
Published: (2025-01-01)

Brain Iron Deposition Alterations in Type 2 Diabetes Mellitus Patients With Mild Cognitive Impairment Based on Quantitative Susceptibility Mapping
by: Qiuyue Zhao, et al.
Published: (2025-01-01)

Predicting Cognitive Decline in Parkinson’s Disease with Mild Cognitive Impairment: A One-Year Observational Study
by: Pei-Hao Chen, et al.
Published: (2020-01-01)

Gene Polymorphisms and Susceptibility to Functional Dyspepsia: A Systematic Review and Meta-Analysis
by: Lijun Du, et al.
Published: (2019-01-01)

Diffusion Tensor Imaging in Alzheimer’s Disease and Mild Cognitive Impairment
by: G. T. Stebbins, et al.
Published: (2009-01-01)

Neuropsychiatric Symptoms in Parkinson's Disease with Mild Cognitive Impairment and Dementia
by: Iracema Leroi, et al.
Published: (2012-01-01)

Elevated Osteopontin Levels in Mild Cognitive Impairment and Alzheimer’s Disease
by: Yuan Sun, et al.
Published: (2013-01-01)

Movements Execution in Amnestic Mild Cognitive Impairment and Alzheimer’s Disease
by: Rosolino Camarda, et al.
Published: (2007-01-01)

Abstract Word Definition in Patients with Amnestic Mild Cognitive Impairment
by: Soo Ryon Kim, et al.
Published: (2015-01-01)

Neural mechanisms of non-pharmacological interventions in patients with mild cognitive impairment and Alzheimer's disease: An ALE meta-analysis
by: Ning Wang, et al.
Published: (2025-02-01)

Effects of Transcranial Direct-Current Stimulation and Cognitive Training on Individuals with Mild Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis
by: Ka Yin Chu, et al.
Published: (2024-11-01)

Interleukin-18 Gene Polymorphisms and Rheumatoid Arthritis Susceptibility: An Umbrella Review of Meta-Analyses
by: Yuehong Chen, et al.
Published: (2024-01-01)

Quality of Life in Mild Cognitive Impairment and Mild Dementia Associated with Alzheimer’s Disease: A Systematic Review
by: Joanna Campbell, et al.
Published: (2024-11-01)

Online applications as a protective factor for amnestic mild cognitive impairment
by: Yordanis Garbey Pierre, et al.
Published: (2024-05-01)

The proof is in the pudding: patient engagement in studying cannabidiol in mild cognitive impairment
by: Antonia Keck, et al.
Published: (2025-01-01)

Clinical evidence of acupuncture for amnestic mild cognitive impairment: A systematic review and meta-analysis of randomized controlled trials
by: Guangyao Lin, et al.
Published: (2025-03-01)

The Associations between VEGF Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Meta-Analysis of 11 Case-Control Studies
by: Liyuan Han, et al.
Published: (2014-01-01)

The Polymorphisms with Cataract Susceptibility Impair the EPHA2 Receptor Stability and Its Cytoprotective Function
by: Jin Yang, et al.
Published: (2015-01-01)

Association between echocardiographic parameters of cardiac structure and function and mild cognitive impairment
by: Kai Zhang, et al.
Published: (2025-02-01)

Transcranial Doppler sonography follow-up study in mild vascular cognitive impairment.
by: Mariagiovanna Cantone, et al.
Published: (2025-01-01)

Trait Impulsivity Is Independent of Mild Cognitive Impairment in a Parkinson’s Disease Cohort
by: Ashani Jeyadevan, et al.
Published: (2019-01-01)

A Novel Metabolic Connectome Method to Predict Progression to Mild Cognitive Impairment
by: Min Wang, et al.
Published: (2020-01-01)

Elderly Patients with Mild Cognitive Impairment Exhibit Altered Gut Microbiota Profiles
by: Qiong Pan, et al.
Published: (2021-01-01)

Comment on “Choroidal Thickness in Patients with Mild Cognitive Impairment and Alzheimer’s Type Dementia”
by: Abdullah Ilhan, et al.
Published: (2016-01-01)

Development and validation of a frailty risk model for patients with mild cognitive impairment
by: Yuyu Cui, et al.
Published: (2025-01-01)

Lipid trajectories improve risk models for Alzheimer’s disease and mild cognitive impairment
by: Bruce A. Chase, et al.
Published: (2025-01-01)

Multimodal MRI Neuroimaging Biomarkers for Cognitive Normal Adults, Amnestic Mild Cognitive Impairment, and Alzheimer's Disease
by: Ai-Ling Lin, et al.
Published: (2012-01-01)

Structural Alteration of Medial Temporal Lobe Subfield in the Amnestic Mild Cognitive Impairment Stage of Alzheimer’s Disease
by: Pan He, et al.
Published: (2022-01-01)