The relationship between mixed exposure to blood metal and serum neurofilament light chain levels in the general U.S. population: an unsupervised clustering approach

The relationship between mixed exposure to blood metal and serum neurofilament light chain levels in the general U.S. population: an unsupervised clustering approach

BackgroundSerum neurofilament light chain (sNfL) has demonstrate significant clinical value in quantifying neuronal injury. Concurrently, extensive evidence has linked metal exposure to neurotoxic effects. However, the potential association between metal exposure and circulating sNfL levels remains...

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Bibliographic Details
Main Authors: Jiyu Nie, Lin Wen, Zhentian Lai, Chuhang Lin, Haiyin Li, Jing Zhang, Shen Xie, Xiaosong Ben, Chunxia Jing
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Public Health
Subjects:
metal exposure
serum neurofilament light chain
unsupervised machine learning
BKMR
G-computation
Online Access:https://www.frontiersin.org/articles/10.3389/fpubh.2025.1516879/full
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