Mechanism and Treatment Strategy of Osteoporosis after Transplantation
Osteoporosis (OP) has emerged as a frequent and devastating complication of organ solid transplantation process. Bone loss after organ transplant is related to adverse effects of immunosuppressants on bone remodeling and bone quality. Many factors contribute to the pathogenesis of OP in transplanted...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/280164 |
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| author | Lei Song Xu-Biao Xie Long-Kai Peng Shao-Jie Yu Ya-Ting Peng |
| author_facet | Lei Song Xu-Biao Xie Long-Kai Peng Shao-Jie Yu Ya-Ting Peng |
| author_sort | Lei Song |
| collection | DOAJ |
| description | Osteoporosis (OP) has emerged as a frequent and devastating complication of organ solid transplantation process. Bone loss after organ transplant is related to adverse effects of immunosuppressants on bone remodeling and bone quality. Many factors contribute to the pathogenesis of OP in transplanted patients. Many mechanisms of OP have been deeply approached. Drugs for OP can be generally divided into “bone resorption inhibitors” and “bone formation accelerators,” the former hindering bone resorption by osteoclasts and the latter increasing bone formation by osteoblasts. Currently, bisphosphonates, which are bone resorption inhibitors drugs, are more commonly used clinically than others. Using the signaling pathway or implantation bone marrow stem cell provides a novel direction for the treatment of OP, especially OP after transplantation. This review addresses the mechanism of OP and its correlation with organ transplantation, lists prevention and management of bone loss in the transplant recipient, and discusses the recipients of different age and gender. |
| format | Article |
| id | doaj-art-ee2c914bc5c74babb1c848f86bcffff6 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-ee2c914bc5c74babb1c848f86bcffff62025-02-03T06:14:17ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/280164280164Mechanism and Treatment Strategy of Osteoporosis after TransplantationLei Song0Xu-Biao Xie1Long-Kai Peng2Shao-Jie Yu3Ya-Ting Peng4Center of Organ Transplantation, Second Xiangya Hospital of Central South University, Changsha 410011, ChinaCenter of Organ Transplantation, Second Xiangya Hospital of Central South University, Changsha 410011, ChinaCenter of Organ Transplantation, Second Xiangya Hospital of Central South University, Changsha 410011, ChinaCenter of Organ Transplantation, Second Xiangya Hospital of Central South University, Changsha 410011, ChinaDepartment of Respiratory Medicine, Second Xiangya Hospital of Central South University, Changsha 410011, ChinaOsteoporosis (OP) has emerged as a frequent and devastating complication of organ solid transplantation process. Bone loss after organ transplant is related to adverse effects of immunosuppressants on bone remodeling and bone quality. Many factors contribute to the pathogenesis of OP in transplanted patients. Many mechanisms of OP have been deeply approached. Drugs for OP can be generally divided into “bone resorption inhibitors” and “bone formation accelerators,” the former hindering bone resorption by osteoclasts and the latter increasing bone formation by osteoblasts. Currently, bisphosphonates, which are bone resorption inhibitors drugs, are more commonly used clinically than others. Using the signaling pathway or implantation bone marrow stem cell provides a novel direction for the treatment of OP, especially OP after transplantation. This review addresses the mechanism of OP and its correlation with organ transplantation, lists prevention and management of bone loss in the transplant recipient, and discusses the recipients of different age and gender.http://dx.doi.org/10.1155/2015/280164 |
| spellingShingle | Lei Song Xu-Biao Xie Long-Kai Peng Shao-Jie Yu Ya-Ting Peng Mechanism and Treatment Strategy of Osteoporosis after Transplantation International Journal of Endocrinology |
| title | Mechanism and Treatment Strategy of Osteoporosis after Transplantation |
| title_full | Mechanism and Treatment Strategy of Osteoporosis after Transplantation |
| title_fullStr | Mechanism and Treatment Strategy of Osteoporosis after Transplantation |
| title_full_unstemmed | Mechanism and Treatment Strategy of Osteoporosis after Transplantation |
| title_short | Mechanism and Treatment Strategy of Osteoporosis after Transplantation |
| title_sort | mechanism and treatment strategy of osteoporosis after transplantation |
| url | http://dx.doi.org/10.1155/2015/280164 |
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