Glucose Metabolic Brain Network Differences between Chinese Patients with Lewy Body Dementia and Healthy Control
Dementia with Lewy bodies (DLB) is the second most common degenerative dementia of the central nervous system. The technique 18F-fluorodeoxyglucose positron emission tomography (18F FDG PET) was used to investigate brain metabolism patterns in DLB patients. Conventional statistical methods did not c...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2018/8420658 |
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| author | Danyan Chen Jiaying Lu Hucheng Zhou Jiehui Jiang Ping Wu Qihao Guo Jingjie Ge Huiwei Zhang Kuangyu Shi Chuantao Zuo |
| author_facet | Danyan Chen Jiaying Lu Hucheng Zhou Jiehui Jiang Ping Wu Qihao Guo Jingjie Ge Huiwei Zhang Kuangyu Shi Chuantao Zuo |
| author_sort | Danyan Chen |
| collection | DOAJ |
| description | Dementia with Lewy bodies (DLB) is the second most common degenerative dementia of the central nervous system. The technique 18F-fluorodeoxyglucose positron emission tomography (18F FDG PET) was used to investigate brain metabolism patterns in DLB patients. Conventional statistical methods did not consider intern metabolism transforming connections between various brain regions; therefore, most physicians do not understand the underlying neuropathology of DLB patients. In this study, 18F FDG-PET images and graph-theoretical methods were used to investigate alterations in whole-brain intrinsic functional connectivity in a Chinese DLB group and healthy control (HC) group. This experimental study was performed on 22 DLB patients and 22 HC subjects in Huashan Hospital, Shanghai, China. Experimental results indicate that compared with the HC group, the DLB group has severely impaired small-world network. Compared to those of the HC group, the clustering coefficients of the DLB group were higher and characteristic path lengths were longer, and in terms of global efficiencies, those of the DLB group was also lower. Moreover, four significantly altered regions were observed in the DLB group: Inferior frontal gyrus, opercular part (IFG.R), olfactory cortex (OLF.R), hippocampus (HIP.R), and fusiform gyrus (FFG.L). Amongst them, in the DLB group, betweenness centrality became strong in OLF.R, HIP.R, and FFG.L, whereas betweenness centrality became weaker in IFG.R. Finally, IFGoperc.R was selected as a seed and a voxel-wise correlation analysis was performed. Compared to the HC group, the DLB group showed several regions of strengthened connection with IFGoperc.R; these regions were located in the prefrontal cortex and regions of weakened connection were located in the occipital cortex. The results of this paper may help physicians to better understand and characterize DLB patients. |
| format | Article |
| id | doaj-art-ee190b2cd89c453eb045f350dc288d8a |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-ee190b2cd89c453eb045f350dc288d8a2025-02-03T05:49:47ZengWileyBehavioural Neurology0953-41801875-85842018-01-01201810.1155/2018/84206588420658Glucose Metabolic Brain Network Differences between Chinese Patients with Lewy Body Dementia and Healthy ControlDanyan Chen0Jiaying Lu1Hucheng Zhou2Jiehui Jiang3Ping Wu4Qihao Guo5Jingjie Ge6Huiwei Zhang7Kuangyu Shi8Chuantao Zuo9Shanghai Institute for Advanced Communication and Data Science, Shanghai University, Shanghai, ChinaPET Center, Huashan Hospital, Fudan University, Shanghai, ChinaShanghai Institute for Advanced Communication and Data Science, Shanghai University, Shanghai, ChinaShanghai Institute for Advanced Communication and Data Science, Shanghai University, Shanghai, ChinaPET Center, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, ChinaPET Center, Huashan Hospital, Fudan University, Shanghai, ChinaPET Center, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Nuclear Medicine, Technische Universität München, Munich, GermanyPET Center, Huashan Hospital, Fudan University, Shanghai, ChinaDementia with Lewy bodies (DLB) is the second most common degenerative dementia of the central nervous system. The technique 18F-fluorodeoxyglucose positron emission tomography (18F FDG PET) was used to investigate brain metabolism patterns in DLB patients. Conventional statistical methods did not consider intern metabolism transforming connections between various brain regions; therefore, most physicians do not understand the underlying neuropathology of DLB patients. In this study, 18F FDG-PET images and graph-theoretical methods were used to investigate alterations in whole-brain intrinsic functional connectivity in a Chinese DLB group and healthy control (HC) group. This experimental study was performed on 22 DLB patients and 22 HC subjects in Huashan Hospital, Shanghai, China. Experimental results indicate that compared with the HC group, the DLB group has severely impaired small-world network. Compared to those of the HC group, the clustering coefficients of the DLB group were higher and characteristic path lengths were longer, and in terms of global efficiencies, those of the DLB group was also lower. Moreover, four significantly altered regions were observed in the DLB group: Inferior frontal gyrus, opercular part (IFG.R), olfactory cortex (OLF.R), hippocampus (HIP.R), and fusiform gyrus (FFG.L). Amongst them, in the DLB group, betweenness centrality became strong in OLF.R, HIP.R, and FFG.L, whereas betweenness centrality became weaker in IFG.R. Finally, IFGoperc.R was selected as a seed and a voxel-wise correlation analysis was performed. Compared to the HC group, the DLB group showed several regions of strengthened connection with IFGoperc.R; these regions were located in the prefrontal cortex and regions of weakened connection were located in the occipital cortex. The results of this paper may help physicians to better understand and characterize DLB patients.http://dx.doi.org/10.1155/2018/8420658 |
| spellingShingle | Danyan Chen Jiaying Lu Hucheng Zhou Jiehui Jiang Ping Wu Qihao Guo Jingjie Ge Huiwei Zhang Kuangyu Shi Chuantao Zuo Glucose Metabolic Brain Network Differences between Chinese Patients with Lewy Body Dementia and Healthy Control Behavioural Neurology |
| title | Glucose Metabolic Brain Network Differences between Chinese Patients with Lewy Body Dementia and Healthy Control |
| title_full | Glucose Metabolic Brain Network Differences between Chinese Patients with Lewy Body Dementia and Healthy Control |
| title_fullStr | Glucose Metabolic Brain Network Differences between Chinese Patients with Lewy Body Dementia and Healthy Control |
| title_full_unstemmed | Glucose Metabolic Brain Network Differences between Chinese Patients with Lewy Body Dementia and Healthy Control |
| title_short | Glucose Metabolic Brain Network Differences between Chinese Patients with Lewy Body Dementia and Healthy Control |
| title_sort | glucose metabolic brain network differences between chinese patients with lewy body dementia and healthy control |
| url | http://dx.doi.org/10.1155/2018/8420658 |
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