Toxoplasma GRA16 attenuates Tau hyperphosphorylation and enhances autophagy in thrombin-treated HT-22 hippocampal neuronal cells

Toxoplasma GRA16 attenuates Tau hyperphosphorylation and enhances autophagy in thrombin-treated HT-22 hippocampal neuronal cells

Abstract This study investigated whether Toxoplasma gondii-derived dense granule protein 16 (GRA16) modulates tau protein to attenuate tau hyperphosphorylation and promotes autophagy to facilitate the removal of tau aggregates. HT-22 murine hippocampal neuronal cells were treated with thrombin to in...

Full description

Saved in:
Bibliographic Details
Main Authors: Seung-Hwan Seo, Do-Won Ham, Ji-Eun Lee, Eun-Hee Shin
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Autophagy
Dense granule protein 16
Hippocampal neuronal cell
Hyperphosphorylated Tau
Tauopathy
Toxoplasma gondii
Online Access:https://doi.org/10.1038/s41598-025-00271-4
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1038/s41598-025-00271-4

Similar Items