Glial cell line-derived neurotrophic factor in patients with age-related cataract
Purpose. To study the content of glial cell line-derived neurotrophic factor (GDNF) in the aqueous humor (AH), lacrimal fluid (LF), and blood serum (BS) in patients with age-related cataract. Material and methods. The content of GDNF in the LF, AH and BS was studied in 47 patients (47 eyes) with age...
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| Format: | Article |
| Language: | Russian |
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Publishing house "Ophthalmology"
2022-09-01
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| Series: | Офтальмохирургия |
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| Online Access: | https://ophthalmosurgery.ru/index.php/ophthalmosurgery/article/view/363/409 |
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| author | A.A. Shpak A.B. Guekht T.A. Druzhkova A.A. Troshina N.V. Gulyaeva |
| author_facet | A.A. Shpak A.B. Guekht T.A. Druzhkova A.A. Troshina N.V. Gulyaeva |
| author_sort | A.A. Shpak |
| collection | DOAJ |
| description | Purpose. To study the content of glial cell line-derived neurotrophic factor (GDNF) in the aqueous humor (AH), lacrimal fluid (LF), and blood serum (BS) in patients with age-related cataract. Material and methods. The content of GDNF in the LF, AH and BS was studied in 47 patients (47 eyes) with age-related cataract. Collection of stimulated LF was performed with a pipette on the day preceding surgery; the AH and BS were sampled during the phacoemulsification of a cataract. The concentration of GDNF was measured using an enzyme immunoassay. Results. The concentration of GDNF in the AH was 88.9±46.9 (2.0–212.5) pg/ml, in the BS – 201.1±44.6 (103.2–287.2) pg/ml, in the LF – 343.6±133.7 (172.8–683.0) pg/ml. The levels of GDNF in the studied biological fluids did not show any significant correlations with each other. Conclusion. In patients with age-related cataract, the level of GDNF in the AH was relatively low: the concentration of GDNF in the AH was more than 2 times lower than in the BS and almost 4 times lower than in the LF. No significant correlations were found between the concentrations of GDNF in LF, AH and BS. |
| format | Article |
| id | doaj-art-edf9c822eec74627a2e062dc139e260f |
| institution | Kabale University |
| issn | 0235-4160 2312-4970 |
| language | Russian |
| publishDate | 2022-09-01 |
| publisher | Publishing house "Ophthalmology" |
| record_format | Article |
| series | Офтальмохирургия |
| spelling | doaj-art-edf9c822eec74627a2e062dc139e260f2025-01-23T11:51:17ZrusPublishing house "Ophthalmology"Офтальмохирургия0235-41602312-49702022-09-01381210.25276/0235-4160-2022-3-8-12Glial cell line-derived neurotrophic factor in patients with age-related cataractA.A. Shpak0https://orcid.org/0000-0003-0273-3307A.B. Guekht1https://orcid.org/0000-0002-1170-6127T.A. Druzhkova2https://orcid.org/0000-0002-5031-1187A.A. Troshina3https://orcid.org/0000-0002-0218-5139N.V. Gulyaeva4https://orcid.org/0000-0002-5380-7954Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian FederationMoscow Research and Clinical Center for Neuropsychiatry, Moscow, Russian FederationMoscow Research and Clinical Center for Neuropsychiatry, Moscow, Russian FederationInstitute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russian FederationInstitute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russian FederationPurpose. To study the content of glial cell line-derived neurotrophic factor (GDNF) in the aqueous humor (AH), lacrimal fluid (LF), and blood serum (BS) in patients with age-related cataract. Material and methods. The content of GDNF in the LF, AH and BS was studied in 47 patients (47 eyes) with age-related cataract. Collection of stimulated LF was performed with a pipette on the day preceding surgery; the AH and BS were sampled during the phacoemulsification of a cataract. The concentration of GDNF was measured using an enzyme immunoassay. Results. The concentration of GDNF in the AH was 88.9±46.9 (2.0–212.5) pg/ml, in the BS – 201.1±44.6 (103.2–287.2) pg/ml, in the LF – 343.6±133.7 (172.8–683.0) pg/ml. The levels of GDNF in the studied biological fluids did not show any significant correlations with each other. Conclusion. In patients with age-related cataract, the level of GDNF in the AH was relatively low: the concentration of GDNF in the AH was more than 2 times lower than in the BS and almost 4 times lower than in the LF. No significant correlations were found between the concentrations of GDNF in LF, AH and BS.https://ophthalmosurgery.ru/index.php/ophthalmosurgery/article/view/363/409glial cell line-derived neurotrophic factorlacrimal fluidaqueous humorblood serumage-related cataract |
| spellingShingle | A.A. Shpak A.B. Guekht T.A. Druzhkova A.A. Troshina N.V. Gulyaeva Glial cell line-derived neurotrophic factor in patients with age-related cataract Офтальмохирургия glial cell line-derived neurotrophic factor lacrimal fluid aqueous humor blood serum age-related cataract |
| title | Glial cell line-derived neurotrophic factor in patients with age-related cataract |
| title_full | Glial cell line-derived neurotrophic factor in patients with age-related cataract |
| title_fullStr | Glial cell line-derived neurotrophic factor in patients with age-related cataract |
| title_full_unstemmed | Glial cell line-derived neurotrophic factor in patients with age-related cataract |
| title_short | Glial cell line-derived neurotrophic factor in patients with age-related cataract |
| title_sort | glial cell line derived neurotrophic factor in patients with age related cataract |
| topic | glial cell line-derived neurotrophic factor lacrimal fluid aqueous humor blood serum age-related cataract |
| url | https://ophthalmosurgery.ru/index.php/ophthalmosurgery/article/view/363/409 |
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