Smoking and Pulmonary Fibrosis: Novel Insights
The relationship between smoking and pulmonary fibrosis is under debate and intense investigation. The aim of this paper is to review the existing literature and identify further areas of research interest. Recently the negative influence of cigarette smoking on IPF outcome was highlighted, as non-s...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Pulmonary Medicine |
| Online Access: | http://dx.doi.org/10.1155/2011/461439 |
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| author | Katerina D. Samara George Margaritopoulos Athol U. Wells Nikolaos M. Siafakas Katerina M. Antoniou |
| author_facet | Katerina D. Samara George Margaritopoulos Athol U. Wells Nikolaos M. Siafakas Katerina M. Antoniou |
| author_sort | Katerina D. Samara |
| collection | DOAJ |
| description | The relationship between smoking and pulmonary fibrosis is under debate and intense investigation. The aim of this paper is to review the existing literature and identify further areas of research interest. Recently the negative influence of cigarette smoking on IPF outcome was highlighted, as non-smokers exhibit a better survival than ex-smokers and combined current- and ex-smokers. In patients with non-specific interstitial pneumonia (NSIP), a high prevalence of emphysema was recently demonstrated, providing an indirect support for a smoking pathogenetic hypothesis in NSIP. The coexistence of pulmonary fibrosis and emphysema has been extensively described in a syndrome termed combined pulmonary fibrosis and emphysema (CPFE). Connective tissue disorders (CTDs) are a group of autoimmune diseases which affect the lung, as one of the most common and severe manifestations. However, the relationship between smoking and autoimmune disorders is still conflicting. Rheumatoid arthritis results from the interaction between genetic and environmental factors, while the best established environmental factor is tobacco smoking. Smoking has also a negative impact on the response of the RA patients to treatment. The aforementioned smoking-related implications give rise to further research questions and certainly provide one more important reason for physicians to advocate smoking cessation and smoke-free environment. |
| format | Article |
| id | doaj-art-edf5913d177e4d65840dd50a6d8b75dd |
| institution | Kabale University |
| issn | 2090-1836 2090-1844 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Medicine |
| spelling | doaj-art-edf5913d177e4d65840dd50a6d8b75dd2025-02-03T01:11:34ZengWileyPulmonary Medicine2090-18362090-18442011-01-01201110.1155/2011/461439461439Smoking and Pulmonary Fibrosis: Novel InsightsKaterina D. Samara0George Margaritopoulos1Athol U. Wells2Nikolaos M. Siafakas3Katerina M. Antoniou4Department of Thoracic Medicine, Faculty of Medicine, University of Crete, 71110 Heraklion, GreeceInterstitial Lung Disease Unit, Royal Brompton Hospital, London SW3 6NP, UKInterstitial Lung Disease Unit, Royal Brompton Hospital, London SW3 6NP, UKDepartment of Thoracic Medicine, Faculty of Medicine, University of Crete, 71110 Heraklion, GreeceDepartment of Thoracic Medicine, Faculty of Medicine, University of Crete, 71110 Heraklion, GreeceThe relationship between smoking and pulmonary fibrosis is under debate and intense investigation. The aim of this paper is to review the existing literature and identify further areas of research interest. Recently the negative influence of cigarette smoking on IPF outcome was highlighted, as non-smokers exhibit a better survival than ex-smokers and combined current- and ex-smokers. In patients with non-specific interstitial pneumonia (NSIP), a high prevalence of emphysema was recently demonstrated, providing an indirect support for a smoking pathogenetic hypothesis in NSIP. The coexistence of pulmonary fibrosis and emphysema has been extensively described in a syndrome termed combined pulmonary fibrosis and emphysema (CPFE). Connective tissue disorders (CTDs) are a group of autoimmune diseases which affect the lung, as one of the most common and severe manifestations. However, the relationship between smoking and autoimmune disorders is still conflicting. Rheumatoid arthritis results from the interaction between genetic and environmental factors, while the best established environmental factor is tobacco smoking. Smoking has also a negative impact on the response of the RA patients to treatment. The aforementioned smoking-related implications give rise to further research questions and certainly provide one more important reason for physicians to advocate smoking cessation and smoke-free environment.http://dx.doi.org/10.1155/2011/461439 |
| spellingShingle | Katerina D. Samara George Margaritopoulos Athol U. Wells Nikolaos M. Siafakas Katerina M. Antoniou Smoking and Pulmonary Fibrosis: Novel Insights Pulmonary Medicine |
| title | Smoking and Pulmonary Fibrosis: Novel Insights |
| title_full | Smoking and Pulmonary Fibrosis: Novel Insights |
| title_fullStr | Smoking and Pulmonary Fibrosis: Novel Insights |
| title_full_unstemmed | Smoking and Pulmonary Fibrosis: Novel Insights |
| title_short | Smoking and Pulmonary Fibrosis: Novel Insights |
| title_sort | smoking and pulmonary fibrosis novel insights |
| url | http://dx.doi.org/10.1155/2011/461439 |
| work_keys_str_mv | AT katerinadsamara smokingandpulmonaryfibrosisnovelinsights AT georgemargaritopoulos smokingandpulmonaryfibrosisnovelinsights AT atholuwells smokingandpulmonaryfibrosisnovelinsights AT nikolaosmsiafakas smokingandpulmonaryfibrosisnovelinsights AT katerinamantoniou smokingandpulmonaryfibrosisnovelinsights |