Pregnancy Complicated by Maternal MODY 3 and Paternal MODY 2 Diabetes and Subsequent Rapidly Falling Insulin Requirement

Background. ‘Maturity-Onset Diabetes of the Young’ (MODY) or monogenic diabetes accounts for approximately 1–2% of diabetes and is frequently misdiagnosed as type 1 or type 2 diabetes. Here we report a case of a 19-year-old pregnant woman with a MODY 3 diabetes expecting a child to a father with MOD...

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Main Authors: Anastasia Mikuscheva, Adel Mekhail, Benjamin J. Wheeler
Format: Article
Language:English
Published: Wiley 2018-01-01
Series:Case Reports in Obstetrics and Gynecology
Online Access:http://dx.doi.org/10.1155/2018/9451061
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author Anastasia Mikuscheva
Adel Mekhail
Benjamin J. Wheeler
author_facet Anastasia Mikuscheva
Adel Mekhail
Benjamin J. Wheeler
author_sort Anastasia Mikuscheva
collection DOAJ
description Background. ‘Maturity-Onset Diabetes of the Young’ (MODY) or monogenic diabetes accounts for approximately 1–2% of diabetes and is frequently misdiagnosed as type 1 or type 2 diabetes. Here we report a case of a 19-year-old pregnant woman with a MODY 3 diabetes expecting a child to a father with MODY 2 diabetes. Possible inheritance scenarios are described and the implications of these scenarios on the pregnancy and infant are discussed. In addition, the pregnancy was complicated by drastically falling insulin requirements in the mother in the 3rd trimester as well as preterm labour and delivery at 33+4 weeks of gestation.
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spelling doaj-art-ededd9c9e22541e0842ef20105fcbe132025-02-03T05:52:18ZengWileyCase Reports in Obstetrics and Gynecology2090-66842090-66922018-01-01201810.1155/2018/94510619451061Pregnancy Complicated by Maternal MODY 3 and Paternal MODY 2 Diabetes and Subsequent Rapidly Falling Insulin RequirementAnastasia Mikuscheva0Adel Mekhail1Benjamin J. Wheeler2Gynecology and Obstetrics, Southern District Health Board, Dunedin, New ZealandGynecology and Obstetrics, Southern District Health Board, Dunedin, New ZealandDepartment of Women’s and Children’s Health, University of Otago, Dunedin, New ZealandBackground. ‘Maturity-Onset Diabetes of the Young’ (MODY) or monogenic diabetes accounts for approximately 1–2% of diabetes and is frequently misdiagnosed as type 1 or type 2 diabetes. Here we report a case of a 19-year-old pregnant woman with a MODY 3 diabetes expecting a child to a father with MODY 2 diabetes. Possible inheritance scenarios are described and the implications of these scenarios on the pregnancy and infant are discussed. In addition, the pregnancy was complicated by drastically falling insulin requirements in the mother in the 3rd trimester as well as preterm labour and delivery at 33+4 weeks of gestation.http://dx.doi.org/10.1155/2018/9451061
spellingShingle Anastasia Mikuscheva
Adel Mekhail
Benjamin J. Wheeler
Pregnancy Complicated by Maternal MODY 3 and Paternal MODY 2 Diabetes and Subsequent Rapidly Falling Insulin Requirement
Case Reports in Obstetrics and Gynecology
title Pregnancy Complicated by Maternal MODY 3 and Paternal MODY 2 Diabetes and Subsequent Rapidly Falling Insulin Requirement
title_full Pregnancy Complicated by Maternal MODY 3 and Paternal MODY 2 Diabetes and Subsequent Rapidly Falling Insulin Requirement
title_fullStr Pregnancy Complicated by Maternal MODY 3 and Paternal MODY 2 Diabetes and Subsequent Rapidly Falling Insulin Requirement
title_full_unstemmed Pregnancy Complicated by Maternal MODY 3 and Paternal MODY 2 Diabetes and Subsequent Rapidly Falling Insulin Requirement
title_short Pregnancy Complicated by Maternal MODY 3 and Paternal MODY 2 Diabetes and Subsequent Rapidly Falling Insulin Requirement
title_sort pregnancy complicated by maternal mody 3 and paternal mody 2 diabetes and subsequent rapidly falling insulin requirement
url http://dx.doi.org/10.1155/2018/9451061
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