Vaginal Dysbiosis in Infertility: A Comparative Analysis Between Women with Primary and Secondary Infertility
Infertility, both primary and secondary, is strongly influenced by microbiological factors, with the vaginal microbiota playing a key role in reproductive health. Objective: The aim of this study was to characterize the vaginal microbiota of 136 Mexican women diagnosed with infertility—primary (n =...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Microorganisms |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2607/13/1/188 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Infertility, both primary and secondary, is strongly influenced by microbiological factors, with the vaginal microbiota playing a key role in reproductive health. Objective: The aim of this study was to characterize the vaginal microbiota of 136 Mexican women diagnosed with infertility—primary (n = 58) and secondary (n = 78)—by evaluating the presence of pathogenic bacterial species and their associations with infertility conditions. Methods: Samples were obtained through cervical swabs, and microorganism identification was performed using qPCR techniques. Results: Analysis revealed a positive correlation between increased age and the likelihood of primary infertility, as well as a negative correlation with secondary infertility. Significant differences in microbial composition were also observed between the two infertility groups. <i>Lactobacillus crispatus</i> and <i>Lactobacillus gasseri</i> were dominant in women with primary infertility, in addition to a high prevalence of <i>Gardnerella vaginalis</i> and <i>Fannyhessea vaginae</i>. Additionally, correlations were found between the presence of human papillomavirus (HPV) and sexually transmitted bacteria, as well as <i>Gardnerella vaginalis</i>. Conclusion: Our findings suggest that the composition of the vaginal microbiota may play a decisive role in infertility, highlighting the need for personalized therapeutic strategies based on microbial profiles. |
|---|---|
| ISSN: | 2076-2607 |