Utility of Computed Tomographic Enteroclysis/Enterography for the Assessment of Mucosal Healing in Crohn's Disease
Aim. When determining therapeutic strategy, it is important to diagnose small intestinal lesions in Crohn's disease (CD) precisely and to evaluate mucosal healing as well as clinical remission in CD. The purpose of this study was to compare findings from computed tomographic enteroclysis/entero...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2013/984916 |
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| author | Shinichi Hashimoto Kensaku Shimizu Hiroaki Shibata Satoko Kanayama Ryo Tanabe Hideko Onoda Naohumi Matsunaga Isao Sakaida |
| author_facet | Shinichi Hashimoto Kensaku Shimizu Hiroaki Shibata Satoko Kanayama Ryo Tanabe Hideko Onoda Naohumi Matsunaga Isao Sakaida |
| author_sort | Shinichi Hashimoto |
| collection | DOAJ |
| description | Aim. When determining therapeutic strategy, it is important to diagnose small intestinal lesions in Crohn's disease (CD) precisely and to evaluate mucosal healing as well as clinical remission in CD. The purpose of this study was to compare findings from computed tomographic enteroclysis/enterography (CTE) with those from the mucosal surface and to determine whether the state of mucosal healing can be determined by CTE. Materials and Methods. Of the patients who underwent CTE for CD, 39 patients were examined whose mucosal findings could be confirmed by colonoscopy, capsule endoscopy, balloon endoscopy, or with the resected surgical specimens. Results. According to the CTE findings, patients were determined to be in the active CD group (n=31) or inactive CD group (n=8). The proportion of previous surgery, clinical remission, stenosis, and CDAI score all showed significant difference between groups. Mucosal findings showed an association with ulcer in 93.6% of active group patients but in only 12.5% of inactive group patients (P<0.0001), whereas mucosal healing was found in 62.5% of inactive group patients but in only 3.2% of active group patients (P<0.0001). Conclusion. CTE appeared to be a useful diagnostic method for assessment of mucosal healing in Crohn's disease. |
| format | Article |
| id | doaj-art-ede4fe021d694195a9d41eaa668e5662 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-ede4fe021d694195a9d41eaa668e56622025-02-03T05:54:12ZengWileyGastroenterology Research and Practice1687-61211687-630X2013-01-01201310.1155/2013/984916984916Utility of Computed Tomographic Enteroclysis/Enterography for the Assessment of Mucosal Healing in Crohn's DiseaseShinichi Hashimoto0Kensaku Shimizu1Hiroaki Shibata2Satoko Kanayama3Ryo Tanabe4Hideko Onoda5Naohumi Matsunaga6Isao Sakaida7Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, JapanDepartment of Radiology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, JapanDepartment of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, JapanDepartment of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, JapanIryouhoujin-Seijinkai Hayashi Hospital, 751-4 Ogoori-Shimogou, Yamaguchi, Yamaguchi 754-0002, JapanDepartment of Radiology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, JapanDepartment of Radiology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, JapanDepartment of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, JapanAim. When determining therapeutic strategy, it is important to diagnose small intestinal lesions in Crohn's disease (CD) precisely and to evaluate mucosal healing as well as clinical remission in CD. The purpose of this study was to compare findings from computed tomographic enteroclysis/enterography (CTE) with those from the mucosal surface and to determine whether the state of mucosal healing can be determined by CTE. Materials and Methods. Of the patients who underwent CTE for CD, 39 patients were examined whose mucosal findings could be confirmed by colonoscopy, capsule endoscopy, balloon endoscopy, or with the resected surgical specimens. Results. According to the CTE findings, patients were determined to be in the active CD group (n=31) or inactive CD group (n=8). The proportion of previous surgery, clinical remission, stenosis, and CDAI score all showed significant difference between groups. Mucosal findings showed an association with ulcer in 93.6% of active group patients but in only 12.5% of inactive group patients (P<0.0001), whereas mucosal healing was found in 62.5% of inactive group patients but in only 3.2% of active group patients (P<0.0001). Conclusion. CTE appeared to be a useful diagnostic method for assessment of mucosal healing in Crohn's disease.http://dx.doi.org/10.1155/2013/984916 |
| spellingShingle | Shinichi Hashimoto Kensaku Shimizu Hiroaki Shibata Satoko Kanayama Ryo Tanabe Hideko Onoda Naohumi Matsunaga Isao Sakaida Utility of Computed Tomographic Enteroclysis/Enterography for the Assessment of Mucosal Healing in Crohn's Disease Gastroenterology Research and Practice |
| title | Utility of Computed Tomographic Enteroclysis/Enterography for the Assessment of Mucosal Healing in Crohn's Disease |
| title_full | Utility of Computed Tomographic Enteroclysis/Enterography for the Assessment of Mucosal Healing in Crohn's Disease |
| title_fullStr | Utility of Computed Tomographic Enteroclysis/Enterography for the Assessment of Mucosal Healing in Crohn's Disease |
| title_full_unstemmed | Utility of Computed Tomographic Enteroclysis/Enterography for the Assessment of Mucosal Healing in Crohn's Disease |
| title_short | Utility of Computed Tomographic Enteroclysis/Enterography for the Assessment of Mucosal Healing in Crohn's Disease |
| title_sort | utility of computed tomographic enteroclysis enterography for the assessment of mucosal healing in crohn s disease |
| url | http://dx.doi.org/10.1155/2013/984916 |
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