Gut Microbiota-Derived Metabolites in the Development of Diseases
Gut microbiota is increasingly recognized as a metabolic organ essential for human health. Compelling evidences show a variety set of links between diets and gut microbial homeostasis. Changes in gut microbial flora would probably contribute to the development of certain diseases such as diabetes, h...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2021/6658674 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832560076364185600 |
|---|---|
| author | Guangyu Shen Jing Wu Bang-Ce Ye Nan Qi |
| author_facet | Guangyu Shen Jing Wu Bang-Ce Ye Nan Qi |
| author_sort | Guangyu Shen |
| collection | DOAJ |
| description | Gut microbiota is increasingly recognized as a metabolic organ essential for human health. Compelling evidences show a variety set of links between diets and gut microbial homeostasis. Changes in gut microbial flora would probably contribute to the development of certain diseases such as diabetes, heart disease, allergy, and psychiatric diseases. In addition to the composition of gut microbiota, the metabolites derived from gut microbiota have emerged as a pivotal regulator in diseases development. Since high-fat and high-protein diets substantially affect the gut microbial ecology and human health, the current review summarizes the gut microbiota-derived metabolites such as short-chain fatty acids (SCFAs), amino acids, and their derivatives and highlights the mechanisms underlying the host responses to these bioactive substances. |
| format | Article |
| id | doaj-art-ede3e89bd5ac47d4bbf286b4ced9467f |
| institution | Kabale University |
| issn | 1712-9532 1918-1493 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases and Medical Microbiology |
| spelling | doaj-art-ede3e89bd5ac47d4bbf286b4ced9467f2025-02-03T01:28:31ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1712-95321918-14932021-01-01202110.1155/2021/66586746658674Gut Microbiota-Derived Metabolites in the Development of DiseasesGuangyu Shen0Jing Wu1Bang-Ce Ye2Nan Qi3Institute of Engineering Biology and Health, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, Zhejiang, ChinaInstitute of Engineering Biology and Health, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, Zhejiang, ChinaInstitute of Engineering Biology and Health, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, Zhejiang, ChinaInstitute of Engineering Biology and Health, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, Zhejiang, ChinaGut microbiota is increasingly recognized as a metabolic organ essential for human health. Compelling evidences show a variety set of links between diets and gut microbial homeostasis. Changes in gut microbial flora would probably contribute to the development of certain diseases such as diabetes, heart disease, allergy, and psychiatric diseases. In addition to the composition of gut microbiota, the metabolites derived from gut microbiota have emerged as a pivotal regulator in diseases development. Since high-fat and high-protein diets substantially affect the gut microbial ecology and human health, the current review summarizes the gut microbiota-derived metabolites such as short-chain fatty acids (SCFAs), amino acids, and their derivatives and highlights the mechanisms underlying the host responses to these bioactive substances.http://dx.doi.org/10.1155/2021/6658674 |
| spellingShingle | Guangyu Shen Jing Wu Bang-Ce Ye Nan Qi Gut Microbiota-Derived Metabolites in the Development of Diseases Canadian Journal of Infectious Diseases and Medical Microbiology |
| title | Gut Microbiota-Derived Metabolites in the Development of Diseases |
| title_full | Gut Microbiota-Derived Metabolites in the Development of Diseases |
| title_fullStr | Gut Microbiota-Derived Metabolites in the Development of Diseases |
| title_full_unstemmed | Gut Microbiota-Derived Metabolites in the Development of Diseases |
| title_short | Gut Microbiota-Derived Metabolites in the Development of Diseases |
| title_sort | gut microbiota derived metabolites in the development of diseases |
| url | http://dx.doi.org/10.1155/2021/6658674 |
| work_keys_str_mv | AT guangyushen gutmicrobiotaderivedmetabolitesinthedevelopmentofdiseases AT jingwu gutmicrobiotaderivedmetabolitesinthedevelopmentofdiseases AT bangceye gutmicrobiotaderivedmetabolitesinthedevelopmentofdiseases AT nanqi gutmicrobiotaderivedmetabolitesinthedevelopmentofdiseases |