Cardiopulmonary Profile in Streptozotocin-Induced Type 1 Diabetic Rats during Systemic Endotoxemia
This study was designed to determine the severity of cardiopulmonary dysfunction during systemic endotoxemia in type 1 diabetes. Thirty-two adult male Wistar rats were randomly assigned to a control group or to a group treated with streptozotocin (STZ) to create an animal model of type 1 diabetes. S...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2013/494179 |
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| author | Ching-Hsia Hung Che-Ning Chang Yu-Wen Chen Yu-Chung Chen Jann-Inn Tzeng Jhi-Joung Wang |
| author_facet | Ching-Hsia Hung Che-Ning Chang Yu-Wen Chen Yu-Chung Chen Jann-Inn Tzeng Jhi-Joung Wang |
| author_sort | Ching-Hsia Hung |
| collection | DOAJ |
| description | This study was designed to determine the severity of cardiopulmonary dysfunction during systemic endotoxemia in type 1 diabetes. Thirty-two adult male Wistar rats were randomly assigned to a control group or to a group treated with streptozotocin (STZ) to create an animal model of type 1 diabetes. Survival time and cardiovascular parameters were continually monitored in urethane anaesthetized animals receiving intravenous infusion of endotoxin (lipopolysaccharide (LPS)) or saline. We also determined arterial blood gases, lung injury, and tumor necrosis factor-alpha (TNF-α) levels in serum and bronchoalveolar lavage fluid. Before LPS administration, the mean arterial pressure in STZ rats was significantly higher than that in normal rats. After LPS injection, the heart rate drop significantly in STZ rats than that in the control group. Also, the increased levels of TNF-α in serum and lavage fluid after LPS treatment were significantly higher in STZ rats than those in normal rats. Survival time in STZ rats was shorter than that in normal rats after LPS application. Albumin content, wet/dry weight ratio of lung, and lung injury were indistinguishable between STZ and normal rats. These results indicate that the cardiopulmonary change which occurs during LPS-induced endotoxemia is minor in STZ-induced diabetic rats. |
| format | Article |
| id | doaj-art-ede223e921344749bba62d78f9e6a266 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-ede223e921344749bba62d78f9e6a2662025-02-03T05:54:22ZengWileyJournal of Diabetes Research2314-67452314-67532013-01-01201310.1155/2013/494179494179Cardiopulmonary Profile in Streptozotocin-Induced Type 1 Diabetic Rats during Systemic EndotoxemiaChing-Hsia Hung0Che-Ning Chang1Yu-Wen Chen2Yu-Chung Chen3Jann-Inn Tzeng4Jhi-Joung Wang5Department of Physical Therapy, National Cheng Kung University, Tainan 701, TaiwanDepartment of Physical Therapy, National Cheng Kung University, Tainan 701, TaiwanDepartment of Physical Therapy, China Medical University, Taichung 404, TaiwanDivision of Physical Therapy, Department of Physical Medicine and Rehabilitation, Cheng Hsin Rehabilitation Medical Center, Taipei 112, TaiwanDepartment of Food Sciences and Technology, Chia Nan University of Pharmacy and Sciences, Tainan 717, TaiwanDepartment of Medical Research, Chi-Mei Medical Centre, Tainan 710, TaiwanThis study was designed to determine the severity of cardiopulmonary dysfunction during systemic endotoxemia in type 1 diabetes. Thirty-two adult male Wistar rats were randomly assigned to a control group or to a group treated with streptozotocin (STZ) to create an animal model of type 1 diabetes. Survival time and cardiovascular parameters were continually monitored in urethane anaesthetized animals receiving intravenous infusion of endotoxin (lipopolysaccharide (LPS)) or saline. We also determined arterial blood gases, lung injury, and tumor necrosis factor-alpha (TNF-α) levels in serum and bronchoalveolar lavage fluid. Before LPS administration, the mean arterial pressure in STZ rats was significantly higher than that in normal rats. After LPS injection, the heart rate drop significantly in STZ rats than that in the control group. Also, the increased levels of TNF-α in serum and lavage fluid after LPS treatment were significantly higher in STZ rats than those in normal rats. Survival time in STZ rats was shorter than that in normal rats after LPS application. Albumin content, wet/dry weight ratio of lung, and lung injury were indistinguishable between STZ and normal rats. These results indicate that the cardiopulmonary change which occurs during LPS-induced endotoxemia is minor in STZ-induced diabetic rats.http://dx.doi.org/10.1155/2013/494179 |
| spellingShingle | Ching-Hsia Hung Che-Ning Chang Yu-Wen Chen Yu-Chung Chen Jann-Inn Tzeng Jhi-Joung Wang Cardiopulmonary Profile in Streptozotocin-Induced Type 1 Diabetic Rats during Systemic Endotoxemia Journal of Diabetes Research |
| title | Cardiopulmonary Profile in Streptozotocin-Induced Type 1 Diabetic Rats during Systemic Endotoxemia |
| title_full | Cardiopulmonary Profile in Streptozotocin-Induced Type 1 Diabetic Rats during Systemic Endotoxemia |
| title_fullStr | Cardiopulmonary Profile in Streptozotocin-Induced Type 1 Diabetic Rats during Systemic Endotoxemia |
| title_full_unstemmed | Cardiopulmonary Profile in Streptozotocin-Induced Type 1 Diabetic Rats during Systemic Endotoxemia |
| title_short | Cardiopulmonary Profile in Streptozotocin-Induced Type 1 Diabetic Rats during Systemic Endotoxemia |
| title_sort | cardiopulmonary profile in streptozotocin induced type 1 diabetic rats during systemic endotoxemia |
| url | http://dx.doi.org/10.1155/2013/494179 |
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