Ubiquitination Enzymes in Cancer, Cancer Immune Evasion, and Potential Therapeutic Opportunities
Ubiquitination is cells’ second most abundant posttranslational protein modification after phosphorylation. The ubiquitin–proteasome system (UPS) is critical in maintaining essential life processes such as cell cycle control, DNA damage repair, and apoptosis. Mutations in ubiquitination pathway gene...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/14/2/69 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832588873543188480 |
|---|---|
| author | Aiman B. Awan Maryiam Jama Ali Osman Omar M. Khan |
| author_facet | Aiman B. Awan Maryiam Jama Ali Osman Omar M. Khan |
| author_sort | Aiman B. Awan |
| collection | DOAJ |
| description | Ubiquitination is cells’ second most abundant posttranslational protein modification after phosphorylation. The ubiquitin–proteasome system (UPS) is critical in maintaining essential life processes such as cell cycle control, DNA damage repair, and apoptosis. Mutations in ubiquitination pathway genes are strongly linked to the development and spread of multiple cancers since several of the UPS family members possess oncogenic or tumor suppressor activities. This comprehensive review delves into understanding the ubiquitin code, shedding light on its role in cancer cell biology and immune evasion. Furthermore, we highlighted recent advances in the field for targeting the UPS pathway members for effective therapeutic intervention against human cancers. We also discussed the recent update on small-molecule inhibitors and PROTACs and their progress in preclinical and clinical trials. |
| format | Article |
| id | doaj-art-ede1ee2c7bed496fb6504cc640fdf537 |
| institution | Kabale University |
| issn | 2073-4409 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj-art-ede1ee2c7bed496fb6504cc640fdf5372025-01-24T13:26:34ZengMDPI AGCells2073-44092025-01-011426910.3390/cells14020069Ubiquitination Enzymes in Cancer, Cancer Immune Evasion, and Potential Therapeutic OpportunitiesAiman B. Awan0Maryiam Jama Ali Osman1Omar M. Khan2College of Health and Life Sciences, Hamad Bin Khalifa University, Doha P.O. Box 34110, QatarCollege of Health and Life Sciences, Hamad Bin Khalifa University, Doha P.O. Box 34110, QatarCollege of Health and Life Sciences, Hamad Bin Khalifa University, Doha P.O. Box 34110, QatarUbiquitination is cells’ second most abundant posttranslational protein modification after phosphorylation. The ubiquitin–proteasome system (UPS) is critical in maintaining essential life processes such as cell cycle control, DNA damage repair, and apoptosis. Mutations in ubiquitination pathway genes are strongly linked to the development and spread of multiple cancers since several of the UPS family members possess oncogenic or tumor suppressor activities. This comprehensive review delves into understanding the ubiquitin code, shedding light on its role in cancer cell biology and immune evasion. Furthermore, we highlighted recent advances in the field for targeting the UPS pathway members for effective therapeutic intervention against human cancers. We also discussed the recent update on small-molecule inhibitors and PROTACs and their progress in preclinical and clinical trials.https://www.mdpi.com/2073-4409/14/2/69ubiquitinationcell cycleE3 ligasesoncogenestumor suppressorPROTACs |
| spellingShingle | Aiman B. Awan Maryiam Jama Ali Osman Omar M. Khan Ubiquitination Enzymes in Cancer, Cancer Immune Evasion, and Potential Therapeutic Opportunities Cells ubiquitination cell cycle E3 ligases oncogenes tumor suppressor PROTACs |
| title | Ubiquitination Enzymes in Cancer, Cancer Immune Evasion, and Potential Therapeutic Opportunities |
| title_full | Ubiquitination Enzymes in Cancer, Cancer Immune Evasion, and Potential Therapeutic Opportunities |
| title_fullStr | Ubiquitination Enzymes in Cancer, Cancer Immune Evasion, and Potential Therapeutic Opportunities |
| title_full_unstemmed | Ubiquitination Enzymes in Cancer, Cancer Immune Evasion, and Potential Therapeutic Opportunities |
| title_short | Ubiquitination Enzymes in Cancer, Cancer Immune Evasion, and Potential Therapeutic Opportunities |
| title_sort | ubiquitination enzymes in cancer cancer immune evasion and potential therapeutic opportunities |
| topic | ubiquitination cell cycle E3 ligases oncogenes tumor suppressor PROTACs |
| url | https://www.mdpi.com/2073-4409/14/2/69 |
| work_keys_str_mv | AT aimanbawan ubiquitinationenzymesincancercancerimmuneevasionandpotentialtherapeuticopportunities AT maryiamjamaaliosman ubiquitinationenzymesincancercancerimmuneevasionandpotentialtherapeuticopportunities AT omarmkhan ubiquitinationenzymesincancercancerimmuneevasionandpotentialtherapeuticopportunities |