Evaluating the Role of Wnt Signal Transduction in Promoting the Development of the Heart
Wnts are a family of secreted signaling proteins that are encoded by 19 distinct genes in the vertebrate genome. These molecules initiate several signal transduction pathways: the canonical Wnt, Wnt/Ca2+, and Wnt/planar cell polarity pathways. Wnt proteins have major impact on embryonic development,...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2007-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2007.71 |
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| _version_ | 1832568326080954368 |
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| author | Leonard M. Eisenberg Carol A. Eisenberg |
| author_facet | Leonard M. Eisenberg Carol A. Eisenberg |
| author_sort | Leonard M. Eisenberg |
| collection | DOAJ |
| description | Wnts are a family of secreted signaling proteins that are encoded by 19 distinct genes in the vertebrate genome. These molecules initiate several signal transduction pathways: the canonical Wnt, Wnt/Ca2+, and Wnt/planar cell polarity pathways. Wnt proteins have major impact on embryonic development, tumor progression, and stem cell differentiation. Wnt signal transduction also influences the formation of the heart, yet many issues concerning the involvement of Wnt regulation in initiating cardiac development remain unresolved. In this review, we will examine the published record to discern (a) what has been shown by experimental studies on the participation of Wnt signaling in cardiogenesis, and (b) what are the important questions that need to be addressed to understand the importance and function of Wnt signal transduction in facilitating the development of the heart. |
| format | Article |
| id | doaj-art-edcde4a93138487e94177c392822f197 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-edcde4a93138487e94177c392822f1972025-02-03T00:59:25ZengWileyThe Scientific World Journal1537-744X2007-01-01716117610.1100/tsw.2007.71Evaluating the Role of Wnt Signal Transduction in Promoting the Development of the HeartLeonard M. Eisenberg0Carol A. Eisenberg1Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, USADepartment of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, USAWnts are a family of secreted signaling proteins that are encoded by 19 distinct genes in the vertebrate genome. These molecules initiate several signal transduction pathways: the canonical Wnt, Wnt/Ca2+, and Wnt/planar cell polarity pathways. Wnt proteins have major impact on embryonic development, tumor progression, and stem cell differentiation. Wnt signal transduction also influences the formation of the heart, yet many issues concerning the involvement of Wnt regulation in initiating cardiac development remain unresolved. In this review, we will examine the published record to discern (a) what has been shown by experimental studies on the participation of Wnt signaling in cardiogenesis, and (b) what are the important questions that need to be addressed to understand the importance and function of Wnt signal transduction in facilitating the development of the heart.http://dx.doi.org/10.1100/tsw.2007.71 |
| spellingShingle | Leonard M. Eisenberg Carol A. Eisenberg Evaluating the Role of Wnt Signal Transduction in Promoting the Development of the Heart The Scientific World Journal |
| title | Evaluating the Role of Wnt Signal Transduction in Promoting the Development of the Heart |
| title_full | Evaluating the Role of Wnt Signal Transduction in Promoting the Development of the Heart |
| title_fullStr | Evaluating the Role of Wnt Signal Transduction in Promoting the Development of the Heart |
| title_full_unstemmed | Evaluating the Role of Wnt Signal Transduction in Promoting the Development of the Heart |
| title_short | Evaluating the Role of Wnt Signal Transduction in Promoting the Development of the Heart |
| title_sort | evaluating the role of wnt signal transduction in promoting the development of the heart |
| url | http://dx.doi.org/10.1100/tsw.2007.71 |
| work_keys_str_mv | AT leonardmeisenberg evaluatingtheroleofwntsignaltransductioninpromotingthedevelopmentoftheheart AT carolaeisenberg evaluatingtheroleofwntsignaltransductioninpromotingthedevelopmentoftheheart |