Peripheral Arterial Disease in Type 2 Diabetes Is Associated with an Increase in Fibrinogen Levels
Background. The present study is undertaken to investigate the fibrinogen levels in type 2 diabetes mellitus (T2DM) and its relation to peripheral artery disease (PAD) based on a more accurate and applied noninvasive measurements of duplex ultrasonography. Methods. We performed a cross-sectional stu...
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Wiley
2018-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2018/3709534 |
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| author | Qin-Fen Chen Dan Cao Ting-Ting Ye Hui-Hui Deng Hong Zhu |
| author_facet | Qin-Fen Chen Dan Cao Ting-Ting Ye Hui-Hui Deng Hong Zhu |
| author_sort | Qin-Fen Chen |
| collection | DOAJ |
| description | Background. The present study is undertaken to investigate the fibrinogen levels in type 2 diabetes mellitus (T2DM) and its relation to peripheral artery disease (PAD) based on a more accurate and applied noninvasive measurements of duplex ultrasonography. Methods. We performed a cross-sectional study including 1096 T2DM patients (474 males and 622 females). The odds ratios (ORs) and 95% confidence intervals (CIs) were presented to show the association between PAD and fibrinogen in the subjects divided by fibrinogen levels quarterly. Furthermore, the univariate and multiple logistic analyses were performed to explore the correlation between PAD and fibrinogen levels, individual components in the cross-sectional study. Results. Finally, 887 (80.9%) T2DM patients meet the diagnostic criteria of PAD and these patients had considerably higher serum fibrinogen concentration than non-PAD group (P<0.001). Multiple logistic analyses revealed that higher fibrinogen quartiles were positively related with the development of PAD in the adjusted model. After adjusting for known confounding parameters, the ORs for PAD were 1.993 (95% CI: 1.322-3.005, P<0.001), 2.469 (95% CI: 1.591-3.831, P<0.001), and 2.942 (95% CI, 1.838-4.711, P<0.001) for Q2, Q3, and Q4, respectively (all P values <0.05). Conclusions. Our results suggest that serum fibrinogen concentration can be considered as an independent risk factor for PAD in T2DM patients. |
| format | Article |
| id | doaj-art-edc18ce0db034381add0683f966335b8 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
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| series | International Journal of Endocrinology |
| spelling | doaj-art-edc18ce0db034381add0683f966335b82025-02-03T07:24:19ZengWileyInternational Journal of Endocrinology1687-83371687-83452018-01-01201810.1155/2018/37095343709534Peripheral Arterial Disease in Type 2 Diabetes Is Associated with an Increase in Fibrinogen LevelsQin-Fen Chen0Dan Cao1Ting-Ting Ye2Hui-Hui Deng3Hong Zhu4Medical and Health Care Center, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, ChinaSchool of the First Clinical Medical Sciences, Wenzhou Medical University, Wenzhou 325000, ChinaDepartment of Endocrinology and Metabolism, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, ChinaDepartment of Endocrinology and Metabolism, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, ChinaDepartment of Endocrinology and Metabolism, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, ChinaBackground. The present study is undertaken to investigate the fibrinogen levels in type 2 diabetes mellitus (T2DM) and its relation to peripheral artery disease (PAD) based on a more accurate and applied noninvasive measurements of duplex ultrasonography. Methods. We performed a cross-sectional study including 1096 T2DM patients (474 males and 622 females). The odds ratios (ORs) and 95% confidence intervals (CIs) were presented to show the association between PAD and fibrinogen in the subjects divided by fibrinogen levels quarterly. Furthermore, the univariate and multiple logistic analyses were performed to explore the correlation between PAD and fibrinogen levels, individual components in the cross-sectional study. Results. Finally, 887 (80.9%) T2DM patients meet the diagnostic criteria of PAD and these patients had considerably higher serum fibrinogen concentration than non-PAD group (P<0.001). Multiple logistic analyses revealed that higher fibrinogen quartiles were positively related with the development of PAD in the adjusted model. After adjusting for known confounding parameters, the ORs for PAD were 1.993 (95% CI: 1.322-3.005, P<0.001), 2.469 (95% CI: 1.591-3.831, P<0.001), and 2.942 (95% CI, 1.838-4.711, P<0.001) for Q2, Q3, and Q4, respectively (all P values <0.05). Conclusions. Our results suggest that serum fibrinogen concentration can be considered as an independent risk factor for PAD in T2DM patients.http://dx.doi.org/10.1155/2018/3709534 |
| spellingShingle | Qin-Fen Chen Dan Cao Ting-Ting Ye Hui-Hui Deng Hong Zhu Peripheral Arterial Disease in Type 2 Diabetes Is Associated with an Increase in Fibrinogen Levels International Journal of Endocrinology |
| title | Peripheral Arterial Disease in Type 2 Diabetes Is Associated with an Increase in Fibrinogen Levels |
| title_full | Peripheral Arterial Disease in Type 2 Diabetes Is Associated with an Increase in Fibrinogen Levels |
| title_fullStr | Peripheral Arterial Disease in Type 2 Diabetes Is Associated with an Increase in Fibrinogen Levels |
| title_full_unstemmed | Peripheral Arterial Disease in Type 2 Diabetes Is Associated with an Increase in Fibrinogen Levels |
| title_short | Peripheral Arterial Disease in Type 2 Diabetes Is Associated with an Increase in Fibrinogen Levels |
| title_sort | peripheral arterial disease in type 2 diabetes is associated with an increase in fibrinogen levels |
| url | http://dx.doi.org/10.1155/2018/3709534 |
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