Human neutrophil defensin-1 binding increases histidine kinase activity of SaeS in Staphylococcus aureus

Human neutrophil defensin-1 binding increases histidine kinase activity of SaeS in Staphylococcus aureus

Human neutrophil defensin-1 (HNP-1) can specifically activate the SaeRS two-component system(TCS), which is essential for controlling virulence and immune evasion factors in Staphylococcus aureus. The reaction to HNP1 requires the transmembrane domain of SaeS (SaeS™), however the precise mechanism i...

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Bibliographic Details
Main Authors: Zhengfei Qi, Shuru Lin, Quanxiang Yu, Rui Ma, Kexin Zhang, Wenqi Jiang, Shurong Chen, Yilin Mai, Qingshan Bill Fu
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Biochemistry and Biophysics Reports
Subjects:
Two-component system
SaeS™
Bicelles
HNP1
Kinase activity
Online Access:http://www.sciencedirect.com/science/article/pii/S240558082500069X
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