Central Giant Cell Granuloma of Posterior Maxilla: First Expression of Primary Hyperparathyroidism
A case of 19-year-old male patient reported with the chief complaint of slowly growing diffuse painless swelling over the right part of the face from last 6 months. Intraoral examination revealed a swelling on right side of palate in relation to molar region with buccal cortical plate expansion. Rad...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/170412 |
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| author | Deepanshu Gulati Vishal Bansal Prajesh Dubey Sanjay Pandey Abhinav Agrawal |
| author_facet | Deepanshu Gulati Vishal Bansal Prajesh Dubey Sanjay Pandey Abhinav Agrawal |
| author_sort | Deepanshu Gulati |
| collection | DOAJ |
| description | A case of 19-year-old male patient reported with the chief complaint of slowly growing diffuse painless swelling over the right part of the face from last 6 months. Intraoral examination revealed a swelling on right side of palate in relation to molar region with buccal cortical plate expansion. Radiographic examination (orthopantograph and 3DCT) showed large multilocular radiolucency in right maxilla with generalized loss of lamina dura. Incisional biopsy was done and specimen was sent for histopathological examination which showed multinucleated giant cells containing 15–30 nuclei. Based on clinical, radiological, and histopathological findings provisional diagnosis of central giant cell granuloma was made. Blood tests after histopathology demonstrated elevated serum calcium level and alkaline phosphatase level. Immunoassay of parathyroid hormone (PTH) level was found to be highly elevated. Radiographic examination of long bones like humerus and femur, mandible, and skull was also done which showed osteoclastic lesions. Considering the clinical, radiographic, histopathological, and blood investigation findings, final diagnosis of brown tumour of maxilla was made. The patient underwent partial parathyroidectomy under general anaesthesia to control primary hyperparathyroidism. Surgical removal of the bony lesion was done by curettage. The patient has been followed up for 1 year with no postoperative complications and the lesion healed uneventfully. |
| format | Article |
| id | doaj-art-eda769ec5c61467b8516d46c1a05a3a4 |
| institution | Kabale University |
| issn | 2090-6501 2090-651X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
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| series | Case Reports in Endocrinology |
| spelling | doaj-art-eda769ec5c61467b8516d46c1a05a3a42025-02-03T05:51:39ZengWileyCase Reports in Endocrinology2090-65012090-651X2015-01-01201510.1155/2015/170412170412Central Giant Cell Granuloma of Posterior Maxilla: First Expression of Primary HyperparathyroidismDeepanshu Gulati0Vishal Bansal1Prajesh Dubey2Sanjay Pandey3Abhinav Agrawal4Department of Oral and Maxillofacial Surgery, Subharti Dental College, Meerut 250005, IndiaDepartment of Oral and Maxillofacial Surgery, Subharti Dental College, Meerut 250005, IndiaDepartment of Oral and Maxillofacial Surgery, Subharti Dental College, Meerut 250005, IndiaDepartment of General Surgery, Subharti Medical College, Meerut 250005, IndiaDepartment of General Medicine, Subharti Medical College, Meerut 250005, IndiaA case of 19-year-old male patient reported with the chief complaint of slowly growing diffuse painless swelling over the right part of the face from last 6 months. Intraoral examination revealed a swelling on right side of palate in relation to molar region with buccal cortical plate expansion. Radiographic examination (orthopantograph and 3DCT) showed large multilocular radiolucency in right maxilla with generalized loss of lamina dura. Incisional biopsy was done and specimen was sent for histopathological examination which showed multinucleated giant cells containing 15–30 nuclei. Based on clinical, radiological, and histopathological findings provisional diagnosis of central giant cell granuloma was made. Blood tests after histopathology demonstrated elevated serum calcium level and alkaline phosphatase level. Immunoassay of parathyroid hormone (PTH) level was found to be highly elevated. Radiographic examination of long bones like humerus and femur, mandible, and skull was also done which showed osteoclastic lesions. Considering the clinical, radiographic, histopathological, and blood investigation findings, final diagnosis of brown tumour of maxilla was made. The patient underwent partial parathyroidectomy under general anaesthesia to control primary hyperparathyroidism. Surgical removal of the bony lesion was done by curettage. The patient has been followed up for 1 year with no postoperative complications and the lesion healed uneventfully.http://dx.doi.org/10.1155/2015/170412 |
| spellingShingle | Deepanshu Gulati Vishal Bansal Prajesh Dubey Sanjay Pandey Abhinav Agrawal Central Giant Cell Granuloma of Posterior Maxilla: First Expression of Primary Hyperparathyroidism Case Reports in Endocrinology |
| title | Central Giant Cell Granuloma of Posterior Maxilla: First Expression of Primary Hyperparathyroidism |
| title_full | Central Giant Cell Granuloma of Posterior Maxilla: First Expression of Primary Hyperparathyroidism |
| title_fullStr | Central Giant Cell Granuloma of Posterior Maxilla: First Expression of Primary Hyperparathyroidism |
| title_full_unstemmed | Central Giant Cell Granuloma of Posterior Maxilla: First Expression of Primary Hyperparathyroidism |
| title_short | Central Giant Cell Granuloma of Posterior Maxilla: First Expression of Primary Hyperparathyroidism |
| title_sort | central giant cell granuloma of posterior maxilla first expression of primary hyperparathyroidism |
| url | http://dx.doi.org/10.1155/2015/170412 |
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