Synthesis and evaluation of nitrochromene derivatives as potential antileishmanial therapeutics through biological and computational studies

Synthesis and evaluation of nitrochromene derivatives as potential antileishmanial therapeutics through biological and computational studies

Abstract Leishmaniasis is a parasitic disease caused by protozoan organisms belonging to the Leishmania genus, affecting many individuals worldwide, with the burden surpassing one million cases. This disease leads to considerable morbidity and mortality, predominantly within tropical and subtropical...

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Main Authors: Niloofar Javid, Ali Asadipour, Ehsan Salarkia, Mohammad Amin Langarizadeh, Fatemeh Sharifi, Mohammad Mahdavi, Bagher Amirheidari, Aida Iraji, Hojjat Rezaiezadeh, Gholamreza Hassanpour, Yaghoub Pourshojaei
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Nitrochromene
Anti-leishmania
Amastigote
Promastigote
Molecular docking
Online Access:https://doi.org/10.1038/s41598-025-86035-6
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