Could Metabolic Syndrome, Lipodystrophy, and Aging Be Mesenchymal Stem Cell Exhaustion Syndromes?
One of the most important and complex diseases of modern society is metabolic syndrome. This syndrome has not been completely understood, and therefore an effective treatment is not available yet. We propo...
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| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.4061/2011/943216 |
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| author | Eduardo Mansilla Vanina Díaz Aquino Daniel Zambón Gustavo Horacio Marin Karina Mártire Gustavo Roque Thomas Ichim Neil H. Riordan Amit Patel Flavio Sturla Gustavo Larsen Rubén Spretz Luis Núñez Carlos Soratti Ricardo Ibar Michiel van Leeuwen José María Tau Hugo Drago Alberto Maceira |
| author_facet | Eduardo Mansilla Vanina Díaz Aquino Daniel Zambón Gustavo Horacio Marin Karina Mártire Gustavo Roque Thomas Ichim Neil H. Riordan Amit Patel Flavio Sturla Gustavo Larsen Rubén Spretz Luis Núñez Carlos Soratti Ricardo Ibar Michiel van Leeuwen José María Tau Hugo Drago Alberto Maceira |
| author_sort | Eduardo Mansilla |
| collection | DOAJ |
| description | One of the most
important and complex diseases of modern society
is metabolic syndrome. This syndrome has not
been completely understood, and therefore an
effective treatment is not available yet. We
propose a possible stem cell mechanism involved
in the development of metabolic syndrome. This
way of thinking lets us consider also other
significant pathologies that could have similar
etiopathogenic pathways, like lipodystrophic
syndromes, progeria, and aging. All these
clinical situations could be the consequence of
a progressive and persistent stem cell
exhaustion syndrome (SCES). The main outcome of
this SCES would be an irreversible loss of the
effective regenerative mesenchymal stem cells
(MSCs) pools. In this way, the normal repairing
capacities of the organism could become
inefficient. Our point of view could open the
possibility for a new strategy of treatment in
metabolic syndrome, lipodystrophic syndromes,
progeria, and even aging: stem cell
therapies. |
| format | Article |
| id | doaj-art-ed9b4ad097384c118a5f0313e858e047 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-ed9b4ad097384c118a5f0313e858e0472025-02-03T01:28:40ZengWileyStem Cells International1687-966X1687-96782011-01-01201110.4061/2011/943216943216Could Metabolic Syndrome, Lipodystrophy, and Aging Be Mesenchymal Stem Cell Exhaustion Syndromes?Eduardo Mansilla0Vanina Díaz Aquino1Daniel Zambón2Gustavo Horacio Marin3Karina Mártire4Gustavo Roque5Thomas Ichim6Neil H. Riordan7Amit Patel8Flavio Sturla9Gustavo Larsen10Rubén Spretz11Luis Núñez12Carlos Soratti13Ricardo Ibar14Michiel van Leeuwen15José María Tau16Hugo Drago17Alberto Maceira18Tissue Engineering, Regenerative Medicine and Cell Therapies Laboratory, CUCAIBA, Ministry of Health, Province of Buenos Aires, 1900 La Plata, ArgentinaTissue Engineering, Regenerative Medicine and Cell Therapies Laboratory, CUCAIBA, Ministry of Health, Province of Buenos Aires, 1900 La Plata, ArgentinaLipid Clinic, Division of Endocrinology, Hospital Clinic, 08036 Barcelona, SpainTissue Engineering, Regenerative Medicine and Cell Therapies Laboratory, CUCAIBA, Ministry of Health, Province of Buenos Aires, 1900 La Plata, ArgentinaTissue Engineering, Regenerative Medicine and Cell Therapies Laboratory, CUCAIBA, Ministry of Health, Province of Buenos Aires, 1900 La Plata, ArgentinaTissue Engineering, Regenerative Medicine and Cell Therapies Laboratory, CUCAIBA, Ministry of Health, Province of Buenos Aires, 1900 La Plata, ArgentinaDivision of Endometrial Regenerative Stem Cells, Medistem Inc., San Diego, CA 92122, USADivision of Endometrial Regenerative Stem Cells, Medistem Inc., San Diego, CA 92122, USADivision of Cardiothoracic Surgery, University of Utah, Salt Lake City, UT 84132, USADivision Skin Bank, Burns Hospital, Buenos Aires City, C1424BSD, ArgentinaLNK Chemsolutions, Division of Nanotechnology, Lincoln, NE 68521, USALNK Chemsolutions, Division of Nanotechnology, Lincoln, NE 68521, USAThe University of Chicago, Division of Nanotechnology, Chicago, IL 60637, USAINCUCAI, Presidency, Ministry of Health, 2250-C1428BAJ Buenos Aires, ArgentinaINCUCAI, Presidency, Ministry of Health, 2250-C1428BAJ Buenos Aires, ArgentinaVrije Universiteit, Burns Division, 1081 HV Amsterdam, The NetherlandsTissue Engineering, Regenerative Medicine and Cell Therapies Laboratory, CUCAIBA, Ministry of Health, Province of Buenos Aires, 1900 La Plata, ArgentinaDivision Skin Bank, Burns Hospital, Buenos Aires City, C1424BSD, ArgentinaTissue Engineering, Regenerative Medicine and Cell Therapies Laboratory, CUCAIBA, Ministry of Health, Province of Buenos Aires, 1900 La Plata, ArgentinaOne of the most important and complex diseases of modern society is metabolic syndrome. This syndrome has not been completely understood, and therefore an effective treatment is not available yet. We propose a possible stem cell mechanism involved in the development of metabolic syndrome. This way of thinking lets us consider also other significant pathologies that could have similar etiopathogenic pathways, like lipodystrophic syndromes, progeria, and aging. All these clinical situations could be the consequence of a progressive and persistent stem cell exhaustion syndrome (SCES). The main outcome of this SCES would be an irreversible loss of the effective regenerative mesenchymal stem cells (MSCs) pools. In this way, the normal repairing capacities of the organism could become inefficient. Our point of view could open the possibility for a new strategy of treatment in metabolic syndrome, lipodystrophic syndromes, progeria, and even aging: stem cell therapies.http://dx.doi.org/10.4061/2011/943216 |
| spellingShingle | Eduardo Mansilla Vanina Díaz Aquino Daniel Zambón Gustavo Horacio Marin Karina Mártire Gustavo Roque Thomas Ichim Neil H. Riordan Amit Patel Flavio Sturla Gustavo Larsen Rubén Spretz Luis Núñez Carlos Soratti Ricardo Ibar Michiel van Leeuwen José María Tau Hugo Drago Alberto Maceira Could Metabolic Syndrome, Lipodystrophy, and Aging Be Mesenchymal Stem Cell Exhaustion Syndromes? Stem Cells International |
| title | Could Metabolic Syndrome, Lipodystrophy, and Aging Be Mesenchymal Stem Cell Exhaustion Syndromes? |
| title_full | Could Metabolic Syndrome, Lipodystrophy, and Aging Be Mesenchymal Stem Cell Exhaustion Syndromes? |
| title_fullStr | Could Metabolic Syndrome, Lipodystrophy, and Aging Be Mesenchymal Stem Cell Exhaustion Syndromes? |
| title_full_unstemmed | Could Metabolic Syndrome, Lipodystrophy, and Aging Be Mesenchymal Stem Cell Exhaustion Syndromes? |
| title_short | Could Metabolic Syndrome, Lipodystrophy, and Aging Be Mesenchymal Stem Cell Exhaustion Syndromes? |
| title_sort | could metabolic syndrome lipodystrophy and aging be mesenchymal stem cell exhaustion syndromes |
| url | http://dx.doi.org/10.4061/2011/943216 |
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