Diabetic Cardiomyopathy: Current Approach and Potential Diagnostic and Therapeutic Targets
Although ischemic heart disease is the major cause of death in diabetic patients, diabetic cardiomyopathy (DCM) is increasingly recognized as a clinically relevant entity. Considering that it comprises a variety of mechanisms and effects on cardiac function, increasing the risk of heart failure and...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2017/1310265 |
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| author | Georgiana-Emmanuela Gilca Gabriela Stefanescu Oana Badulescu Daniela-Maria Tanase Iris Bararu Manuela Ciocoiu |
| author_facet | Georgiana-Emmanuela Gilca Gabriela Stefanescu Oana Badulescu Daniela-Maria Tanase Iris Bararu Manuela Ciocoiu |
| author_sort | Georgiana-Emmanuela Gilca |
| collection | DOAJ |
| description | Although ischemic heart disease is the major cause of death in diabetic patients, diabetic cardiomyopathy (DCM) is increasingly recognized as a clinically relevant entity. Considering that it comprises a variety of mechanisms and effects on cardiac function, increasing the risk of heart failure and worsening the prognosis of this patient category, DCM represents an important complication of diabetes mellitus, with a silent development in its earlier stages, involving intricate pathophysiological mechanisms, including oxidative stress, defective calcium handling, altered mitochondrial function, remodeling of the extracellular matrix, and consequent deficient cardiomyocyte contractility. While DCM is common in diabetic asymptomatic patients, it is frequently underdiagnosed, due to few diagnostic possibilities in its early stages. Moreover, since a strategy for prevention and treatment in order to improve the prognosis of DCM has not been established, it is important to identify clear pathophysiological landmarks, to pinpoint the available diagnostic possibilities and to spot potential therapeutic targets. |
| format | Article |
| id | doaj-art-ed9a4a080da6483e96a90ef0a257e674 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-ed9a4a080da6483e96a90ef0a257e6742025-02-03T05:46:13ZengWileyJournal of Diabetes Research2314-67452314-67532017-01-01201710.1155/2017/13102651310265Diabetic Cardiomyopathy: Current Approach and Potential Diagnostic and Therapeutic TargetsGeorgiana-Emmanuela Gilca0Gabriela Stefanescu1Oana Badulescu2Daniela-Maria Tanase3Iris Bararu4Manuela Ciocoiu5Department of Pathophysiology, Faculty of Medicine, University of Medicine and Pharmacy “Grigore T. Popa” Iasi, Iasi, RomaniaGastroenterology Department, “Sf. Spiridon” County Clinical Emergency Hospital, University of Medicine and Pharmacy “Grigore T. Popa” Iasi, Iasi, RomaniaDepartment of Pathophysiology, Faculty of Medicine, University of Medicine and Pharmacy “Grigore T. Popa” Iasi, Iasi, Romania3rd Internal Medicine Clinic, “Sf. Spiridon” County Clinical Emergency Hospital, University of Medicine and Pharmacy “Grigore T. Popa” Iasi, Iasi, RomaniaDepartment of Pathophysiology, Faculty of Medicine, University of Medicine and Pharmacy “Grigore T. Popa” Iasi, Iasi, RomaniaDepartment of Pathophysiology, Faculty of Medicine, University of Medicine and Pharmacy “Grigore T. Popa” Iasi, Iasi, RomaniaAlthough ischemic heart disease is the major cause of death in diabetic patients, diabetic cardiomyopathy (DCM) is increasingly recognized as a clinically relevant entity. Considering that it comprises a variety of mechanisms and effects on cardiac function, increasing the risk of heart failure and worsening the prognosis of this patient category, DCM represents an important complication of diabetes mellitus, with a silent development in its earlier stages, involving intricate pathophysiological mechanisms, including oxidative stress, defective calcium handling, altered mitochondrial function, remodeling of the extracellular matrix, and consequent deficient cardiomyocyte contractility. While DCM is common in diabetic asymptomatic patients, it is frequently underdiagnosed, due to few diagnostic possibilities in its early stages. Moreover, since a strategy for prevention and treatment in order to improve the prognosis of DCM has not been established, it is important to identify clear pathophysiological landmarks, to pinpoint the available diagnostic possibilities and to spot potential therapeutic targets.http://dx.doi.org/10.1155/2017/1310265 |
| spellingShingle | Georgiana-Emmanuela Gilca Gabriela Stefanescu Oana Badulescu Daniela-Maria Tanase Iris Bararu Manuela Ciocoiu Diabetic Cardiomyopathy: Current Approach and Potential Diagnostic and Therapeutic Targets Journal of Diabetes Research |
| title | Diabetic Cardiomyopathy: Current Approach and Potential Diagnostic and Therapeutic Targets |
| title_full | Diabetic Cardiomyopathy: Current Approach and Potential Diagnostic and Therapeutic Targets |
| title_fullStr | Diabetic Cardiomyopathy: Current Approach and Potential Diagnostic and Therapeutic Targets |
| title_full_unstemmed | Diabetic Cardiomyopathy: Current Approach and Potential Diagnostic and Therapeutic Targets |
| title_short | Diabetic Cardiomyopathy: Current Approach and Potential Diagnostic and Therapeutic Targets |
| title_sort | diabetic cardiomyopathy current approach and potential diagnostic and therapeutic targets |
| url | http://dx.doi.org/10.1155/2017/1310265 |
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