Reproductive Late Effects in Female Survivors of Childhood Cancer
Childhood cancer treatments can cause female reproductive late effects. Radiation to the hypothalamic-pituitary-ovarian axis is associated with altered menarche, miscarriage, and implantation failure. Patients who receive chemotherapy and/or ovarian radiation are at risk of premature ovarian failure...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Obstetrics and Gynecology International |
| Online Access: | http://dx.doi.org/10.1155/2012/564794 |
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| author | Shivany Gnaneswaran Rebecca Deans Richard J. Cohn |
| author_facet | Shivany Gnaneswaran Rebecca Deans Richard J. Cohn |
| author_sort | Shivany Gnaneswaran |
| collection | DOAJ |
| description | Childhood cancer treatments can cause female reproductive late effects. Radiation to the hypothalamic-pituitary-ovarian axis is associated with altered menarche, miscarriage, and implantation failure. Patients who receive chemotherapy and/or ovarian radiation are at risk of premature ovarian failure; the risk increases with increasing radiation dose, alkylating agent score, combination therapy, and older age at treatment. Ovarian reserve may be assessed using antimullerian hormone assay and ultrasound measurements of ovarian volume and antral follicle count; however, their efficacy is poorly established in this cohort. Fertility preservation options including cryopreservation, oophoropexy, and gonadotropin-releasing hormone analogues may be initiated prior to treatment, although most are still considered experimental. Uterine radiation has been linked to pregnancy complications including miscarriage, premature delivery, stillbirth, low-birth-weight and small-for-gestational-age infants. This paper summarises the literature on female reproductive late effects. The information should facilitate counseling and management of female survivors throughout their reproductive lives. |
| format | Article |
| id | doaj-art-ed950d418c9e442f8acdf8086d9c5a4c |
| institution | Kabale University |
| issn | 1687-9589 1687-9597 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Obstetrics and Gynecology International |
| spelling | doaj-art-ed950d418c9e442f8acdf8086d9c5a4c2025-02-03T01:11:08ZengWileyObstetrics and Gynecology International1687-95891687-95972012-01-01201210.1155/2012/564794564794Reproductive Late Effects in Female Survivors of Childhood CancerShivany Gnaneswaran0Rebecca Deans1Richard J. Cohn2University of New South Wales, Sydney, NSW 2052, AustraliaUniversity of New South Wales, Sydney, NSW 2052, AustraliaUniversity of New South Wales, Sydney, NSW 2052, AustraliaChildhood cancer treatments can cause female reproductive late effects. Radiation to the hypothalamic-pituitary-ovarian axis is associated with altered menarche, miscarriage, and implantation failure. Patients who receive chemotherapy and/or ovarian radiation are at risk of premature ovarian failure; the risk increases with increasing radiation dose, alkylating agent score, combination therapy, and older age at treatment. Ovarian reserve may be assessed using antimullerian hormone assay and ultrasound measurements of ovarian volume and antral follicle count; however, their efficacy is poorly established in this cohort. Fertility preservation options including cryopreservation, oophoropexy, and gonadotropin-releasing hormone analogues may be initiated prior to treatment, although most are still considered experimental. Uterine radiation has been linked to pregnancy complications including miscarriage, premature delivery, stillbirth, low-birth-weight and small-for-gestational-age infants. This paper summarises the literature on female reproductive late effects. The information should facilitate counseling and management of female survivors throughout their reproductive lives.http://dx.doi.org/10.1155/2012/564794 |
| spellingShingle | Shivany Gnaneswaran Rebecca Deans Richard J. Cohn Reproductive Late Effects in Female Survivors of Childhood Cancer Obstetrics and Gynecology International |
| title | Reproductive Late Effects in Female Survivors of Childhood Cancer |
| title_full | Reproductive Late Effects in Female Survivors of Childhood Cancer |
| title_fullStr | Reproductive Late Effects in Female Survivors of Childhood Cancer |
| title_full_unstemmed | Reproductive Late Effects in Female Survivors of Childhood Cancer |
| title_short | Reproductive Late Effects in Female Survivors of Childhood Cancer |
| title_sort | reproductive late effects in female survivors of childhood cancer |
| url | http://dx.doi.org/10.1155/2012/564794 |
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