The Change of Skeletal Muscle Caused by Inflammation in Obesity as the Key Path to Fibrosis: Thoughts on Mechanisms and Intervention Strategies
Obesity leads to a chronic inflammatory state throughout the body, with increased infiltration of immune cells and inflammatory factors in skeletal muscle tissue, and, at the same time, the level of intracellular mitochondrial oxidative stress rises. Meanwhile, obesity is closely related to the deve...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-12-01
|
| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/15/1/20 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832589016208244736 |
|---|---|
| author | Yixuan Li Wenwen Guo Han Li Yuhao Wang Xinwei Liu Wen Kong |
| author_facet | Yixuan Li Wenwen Guo Han Li Yuhao Wang Xinwei Liu Wen Kong |
| author_sort | Yixuan Li |
| collection | DOAJ |
| description | Obesity leads to a chronic inflammatory state throughout the body, with increased infiltration of immune cells and inflammatory factors in skeletal muscle tissue, and, at the same time, the level of intracellular mitochondrial oxidative stress rises. Meanwhile, obesity is closely related to the development of skeletal muscle fibrosis and can affect the metabolic function of skeletal muscle, triggering metabolic disorders such as insulin resistance (IR) and type 2 diabetes (T2D). However, whether there is a mutual regulatory effect between the two pathological states of inflammation and fibrosis in obese skeletal muscle and the specific molecular mechanisms have not been fully clarified. This review focuses on the pathological changes of skeletal muscle inflammation and fibrosis induced by obesity, covering the metabolic changes it causes, such as lipid deposition, mitochondrial dysfunction, and dysregulation of inflammatory factors, aiming to reveal the intricate connections between the two. In terms of intervention strategies, aerobic exercise, dietary modification, and pharmacotherapy can improve skeletal muscle inflammation and fibrosis. This article provides insight into the important roles of inflammation and fibrosis in the treatment of obesity and the management of skeletal muscle diseases, aiming to provide new ideas for the diagnosis and treatment of metabolic diseases such as obesity and IR. |
| format | Article |
| id | doaj-art-ed6f5881e1bd4111b790b091e7ba12de |
| institution | Kabale University |
| issn | 2218-273X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-ed6f5881e1bd4111b790b091e7ba12de2025-01-24T13:24:53ZengMDPI AGBiomolecules2218-273X2024-12-011512010.3390/biom15010020The Change of Skeletal Muscle Caused by Inflammation in Obesity as the Key Path to Fibrosis: Thoughts on Mechanisms and Intervention StrategiesYixuan Li0Wenwen Guo1Han Li2Yuhao Wang3Xinwei Liu4Wen Kong5Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaObesity leads to a chronic inflammatory state throughout the body, with increased infiltration of immune cells and inflammatory factors in skeletal muscle tissue, and, at the same time, the level of intracellular mitochondrial oxidative stress rises. Meanwhile, obesity is closely related to the development of skeletal muscle fibrosis and can affect the metabolic function of skeletal muscle, triggering metabolic disorders such as insulin resistance (IR) and type 2 diabetes (T2D). However, whether there is a mutual regulatory effect between the two pathological states of inflammation and fibrosis in obese skeletal muscle and the specific molecular mechanisms have not been fully clarified. This review focuses on the pathological changes of skeletal muscle inflammation and fibrosis induced by obesity, covering the metabolic changes it causes, such as lipid deposition, mitochondrial dysfunction, and dysregulation of inflammatory factors, aiming to reveal the intricate connections between the two. In terms of intervention strategies, aerobic exercise, dietary modification, and pharmacotherapy can improve skeletal muscle inflammation and fibrosis. This article provides insight into the important roles of inflammation and fibrosis in the treatment of obesity and the management of skeletal muscle diseases, aiming to provide new ideas for the diagnosis and treatment of metabolic diseases such as obesity and IR.https://www.mdpi.com/2218-273X/15/1/20obesityskeletal muscleinflammationfibrosisinsulin resistance |
| spellingShingle | Yixuan Li Wenwen Guo Han Li Yuhao Wang Xinwei Liu Wen Kong The Change of Skeletal Muscle Caused by Inflammation in Obesity as the Key Path to Fibrosis: Thoughts on Mechanisms and Intervention Strategies Biomolecules obesity skeletal muscle inflammation fibrosis insulin resistance |
| title | The Change of Skeletal Muscle Caused by Inflammation in Obesity as the Key Path to Fibrosis: Thoughts on Mechanisms and Intervention Strategies |
| title_full | The Change of Skeletal Muscle Caused by Inflammation in Obesity as the Key Path to Fibrosis: Thoughts on Mechanisms and Intervention Strategies |
| title_fullStr | The Change of Skeletal Muscle Caused by Inflammation in Obesity as the Key Path to Fibrosis: Thoughts on Mechanisms and Intervention Strategies |
| title_full_unstemmed | The Change of Skeletal Muscle Caused by Inflammation in Obesity as the Key Path to Fibrosis: Thoughts on Mechanisms and Intervention Strategies |
| title_short | The Change of Skeletal Muscle Caused by Inflammation in Obesity as the Key Path to Fibrosis: Thoughts on Mechanisms and Intervention Strategies |
| title_sort | change of skeletal muscle caused by inflammation in obesity as the key path to fibrosis thoughts on mechanisms and intervention strategies |
| topic | obesity skeletal muscle inflammation fibrosis insulin resistance |
| url | https://www.mdpi.com/2218-273X/15/1/20 |
| work_keys_str_mv | AT yixuanli thechangeofskeletalmusclecausedbyinflammationinobesityasthekeypathtofibrosisthoughtsonmechanismsandinterventionstrategies AT wenwenguo thechangeofskeletalmusclecausedbyinflammationinobesityasthekeypathtofibrosisthoughtsonmechanismsandinterventionstrategies AT hanli thechangeofskeletalmusclecausedbyinflammationinobesityasthekeypathtofibrosisthoughtsonmechanismsandinterventionstrategies AT yuhaowang thechangeofskeletalmusclecausedbyinflammationinobesityasthekeypathtofibrosisthoughtsonmechanismsandinterventionstrategies AT xinweiliu thechangeofskeletalmusclecausedbyinflammationinobesityasthekeypathtofibrosisthoughtsonmechanismsandinterventionstrategies AT wenkong thechangeofskeletalmusclecausedbyinflammationinobesityasthekeypathtofibrosisthoughtsonmechanismsandinterventionstrategies AT yixuanli changeofskeletalmusclecausedbyinflammationinobesityasthekeypathtofibrosisthoughtsonmechanismsandinterventionstrategies AT wenwenguo changeofskeletalmusclecausedbyinflammationinobesityasthekeypathtofibrosisthoughtsonmechanismsandinterventionstrategies AT hanli changeofskeletalmusclecausedbyinflammationinobesityasthekeypathtofibrosisthoughtsonmechanismsandinterventionstrategies AT yuhaowang changeofskeletalmusclecausedbyinflammationinobesityasthekeypathtofibrosisthoughtsonmechanismsandinterventionstrategies AT xinweiliu changeofskeletalmusclecausedbyinflammationinobesityasthekeypathtofibrosisthoughtsonmechanismsandinterventionstrategies AT wenkong changeofskeletalmusclecausedbyinflammationinobesityasthekeypathtofibrosisthoughtsonmechanismsandinterventionstrategies |