Metabolic Syndrome, Chronic Kidney, and Cardiovascular Diseases: Role of Adipokines
Obesity is a chronic disease, whose incidence is alarmingly growing. It is associated with metabolic abnormalities and cardiovascular complications. These complications are clustered in the metabolic syndrome (MetS) leading to high cardiovascular morbidity and mortality. Obesity predisposes to diab...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.4061/2011/653182 |
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| author | Manfredi Tesauro Maria Paola Canale Giuseppe Rodia Nicola Di Daniele Davide Lauro Angelo Scuteri Carmine Cardillo |
| author_facet | Manfredi Tesauro Maria Paola Canale Giuseppe Rodia Nicola Di Daniele Davide Lauro Angelo Scuteri Carmine Cardillo |
| author_sort | Manfredi Tesauro |
| collection | DOAJ |
| description | Obesity is a chronic disease, whose incidence is alarmingly growing. It is associated with metabolic abnormalities and cardiovascular complications. These complications are clustered in the metabolic syndrome (MetS) leading to high cardiovascular morbidity and mortality. Obesity predisposes to diabetic nephropathy, hypertensive nephrosclerosis, and focal and segmental glomerular sclerosis and represents an independent risk factor for the development and progression of chronic kidney disease (CKD). Albuminuria is a major risk factor for cardiovascular diseases (CVDs). Microalbuminuria has been described as early manifestation of MetS-associated kidney damage and diabetic nephropathy. Obesity and MetS affect renal physiology and metabolism through mechanisms which include altered levels of adipokines such as leptin and adiponectin, oxidative stress, and inflammation. Secretory products of adipose tissue also deeply and negatively influence endothelial function. A better understanding of these interactions will help in designing more effective treatments aimed to protect both renal and cardiovascular systems. |
| format | Article |
| id | doaj-art-ed5c03aaca214436b37470a280812bde |
| institution | Kabale University |
| issn | 2090-0597 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-ed5c03aaca214436b37470a280812bde2025-02-03T06:14:09ZengWileyCardiology Research and Practice2090-05972011-01-01201110.4061/2011/653182653182Metabolic Syndrome, Chronic Kidney, and Cardiovascular Diseases: Role of AdipokinesManfredi Tesauro0Maria Paola Canale1Giuseppe Rodia2Nicola Di Daniele3Davide Lauro4Angelo Scuteri5Carmine Cardillo6Department of Medicina Interna, Università di Tor Vergata, Viale Oxford 81, 00133 Rome, ItalyDepartment of Medicina Interna, Università di Tor Vergata, Viale Oxford 81, 00133 Rome, ItalyDepartment of Medicina Interna, Università di Tor Vergata, Viale Oxford 81, 00133 Rome, ItalyDepartment of Medicina Interna, Università di Tor Vergata, Viale Oxford 81, 00133 Rome, ItalyDepartment of Medicina Interna, Università di Tor Vergata, Viale Oxford 81, 00133 Rome, ItalyUOC Geriatria INRCA, POR Roma, 00189 Rome, ItalyUniversità Cattolica del Sacro Cuore, 00168 Rome, ItalyObesity is a chronic disease, whose incidence is alarmingly growing. It is associated with metabolic abnormalities and cardiovascular complications. These complications are clustered in the metabolic syndrome (MetS) leading to high cardiovascular morbidity and mortality. Obesity predisposes to diabetic nephropathy, hypertensive nephrosclerosis, and focal and segmental glomerular sclerosis and represents an independent risk factor for the development and progression of chronic kidney disease (CKD). Albuminuria is a major risk factor for cardiovascular diseases (CVDs). Microalbuminuria has been described as early manifestation of MetS-associated kidney damage and diabetic nephropathy. Obesity and MetS affect renal physiology and metabolism through mechanisms which include altered levels of adipokines such as leptin and adiponectin, oxidative stress, and inflammation. Secretory products of adipose tissue also deeply and negatively influence endothelial function. A better understanding of these interactions will help in designing more effective treatments aimed to protect both renal and cardiovascular systems.http://dx.doi.org/10.4061/2011/653182 |
| spellingShingle | Manfredi Tesauro Maria Paola Canale Giuseppe Rodia Nicola Di Daniele Davide Lauro Angelo Scuteri Carmine Cardillo Metabolic Syndrome, Chronic Kidney, and Cardiovascular Diseases: Role of Adipokines Cardiology Research and Practice |
| title | Metabolic Syndrome, Chronic Kidney, and Cardiovascular Diseases: Role of Adipokines |
| title_full | Metabolic Syndrome, Chronic Kidney, and Cardiovascular Diseases: Role of Adipokines |
| title_fullStr | Metabolic Syndrome, Chronic Kidney, and Cardiovascular Diseases: Role of Adipokines |
| title_full_unstemmed | Metabolic Syndrome, Chronic Kidney, and Cardiovascular Diseases: Role of Adipokines |
| title_short | Metabolic Syndrome, Chronic Kidney, and Cardiovascular Diseases: Role of Adipokines |
| title_sort | metabolic syndrome chronic kidney and cardiovascular diseases role of adipokines |
| url | http://dx.doi.org/10.4061/2011/653182 |
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