Experimental study of partially oxidized sodium alginate gel combined with myogenic stem cells to improve cardiac function in aged rats with myocardial infarction
[Objective] To investigate the effect of partially oxidized sodium alginate gel combined with intramyocardial injection of myogenic stem cells on cardiac function in aged rats with myocardial infarction. [Methods] The models of myocardial infarction in aged rats were established by ligating the coro...
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Editorial Office of International Journal of Geriatrics
2025-01-01
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| Series: | Guoji laonian yixue zazhi |
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| Online Access: | http://gwll.publish.founderss.cn/thesisDetails#10.3969/j.issn.1674-7593.2025.01.003&lang=en |
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| author | Xinxin Ma Xiaolu Hou Peixin Dong Jiayan Ye Yangyang Gao Ling Huang Xiuping Bai |
| author_facet | Xinxin Ma Xiaolu Hou Peixin Dong Jiayan Ye Yangyang Gao Ling Huang Xiuping Bai |
| author_sort | Xinxin Ma |
| collection | DOAJ |
| description | [Objective] To investigate the effect of partially oxidized sodium alginate gel combined with intramyocardial injection of myogenic stem cells on cardiac function in aged rats with myocardial infarction. [Methods] The models of myocardial infarction in aged rats were established by ligating the coronary arteries and divided randomly into the group of saline control group, sodium alginate group, myogenic stem cells group and sodium alginate combined with myogenic stem cells group(joint group), each had 30 rats.The same amount of corresponding material was injected into the myocardial infarction area of rats in each group respectively.The cardiac structure and function of the rats were evaluated by echocardiography 8 weeks after the operation, and then the rats were executed.The hearts were removed to observe the differences in ventricular remodeling by histological analysis and the angiogenesis and collagen secretion of the ventricular slices were further analyzed. [Results] The echocardiographic indexes, histological indexes, vessel density per unit area, and the percentage of collagen-positive area in the rats of the joint group were better than those in the other groups (P<0.05).The echocardiographic indexes, histological indexes, vessel density per unit area, and the percentage of collagen-positive area in the rats of sodium alginate group and myogenic stem cell groups were better than those in the saline control group (P<0.05), while there was no statistic difference between the sodium alginate group and myogenic stem cells group(P>0.05). [Conclusion] Sodium alginate gel combined with intramyocardial injection of myogenic stem cells can significantly improve the cardiac function in aged rats with myocardial infarction, which also shows the better effects than the injection of sodium alginate or myogenic stem cells separately. |
| format | Article |
| id | doaj-art-ed5ada9b47d9481381247ad8bf232902 |
| institution | Kabale University |
| issn | 1674-7593 |
| language | zho |
| publishDate | 2025-01-01 |
| publisher | Editorial Office of International Journal of Geriatrics |
| record_format | Article |
| series | Guoji laonian yixue zazhi |
| spelling | doaj-art-ed5ada9b47d9481381247ad8bf2329022025-01-21T02:59:39ZzhoEditorial Office of International Journal of GeriatricsGuoji laonian yixue zazhi1674-75932025-01-01461101510.3969/j.issn.1674-7593.2025.01.003Experimental study of partially oxidized sodium alginate gel combined with myogenic stem cells to improve cardiac function in aged rats with myocardial infarctionXinxin Ma0Xiaolu Hou1Peixin Dong2Jiayan Ye3Yangyang Gao4Ling Huang5Xiuping Bai6Department of Cardiology,the Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001Department of Cardiology,the Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001Department of Cardiology,the Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001Department of Cardiology,the Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001Department of Cardiology,the Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001Department of Cardiology,the Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001Department of Cardiology,the Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001[Objective] To investigate the effect of partially oxidized sodium alginate gel combined with intramyocardial injection of myogenic stem cells on cardiac function in aged rats with myocardial infarction. [Methods] The models of myocardial infarction in aged rats were established by ligating the coronary arteries and divided randomly into the group of saline control group, sodium alginate group, myogenic stem cells group and sodium alginate combined with myogenic stem cells group(joint group), each had 30 rats.The same amount of corresponding material was injected into the myocardial infarction area of rats in each group respectively.The cardiac structure and function of the rats were evaluated by echocardiography 8 weeks after the operation, and then the rats were executed.The hearts were removed to observe the differences in ventricular remodeling by histological analysis and the angiogenesis and collagen secretion of the ventricular slices were further analyzed. [Results] The echocardiographic indexes, histological indexes, vessel density per unit area, and the percentage of collagen-positive area in the rats of the joint group were better than those in the other groups (P<0.05).The echocardiographic indexes, histological indexes, vessel density per unit area, and the percentage of collagen-positive area in the rats of sodium alginate group and myogenic stem cell groups were better than those in the saline control group (P<0.05), while there was no statistic difference between the sodium alginate group and myogenic stem cells group(P>0.05). [Conclusion] Sodium alginate gel combined with intramyocardial injection of myogenic stem cells can significantly improve the cardiac function in aged rats with myocardial infarction, which also shows the better effects than the injection of sodium alginate or myogenic stem cells separately.http://gwll.publish.founderss.cn/thesisDetails#10.3969/j.issn.1674-7593.2025.01.003&lang=ensodium alginatemyogenic stem cellsaged ratsmyocardial infarctioncardiac functionventricular remodeling |
| spellingShingle | Xinxin Ma Xiaolu Hou Peixin Dong Jiayan Ye Yangyang Gao Ling Huang Xiuping Bai Experimental study of partially oxidized sodium alginate gel combined with myogenic stem cells to improve cardiac function in aged rats with myocardial infarction Guoji laonian yixue zazhi sodium alginate myogenic stem cells aged rats myocardial infarction cardiac function ventricular remodeling |
| title | Experimental study of partially oxidized sodium alginate gel combined with myogenic stem cells to improve cardiac function in aged rats with myocardial infarction |
| title_full | Experimental study of partially oxidized sodium alginate gel combined with myogenic stem cells to improve cardiac function in aged rats with myocardial infarction |
| title_fullStr | Experimental study of partially oxidized sodium alginate gel combined with myogenic stem cells to improve cardiac function in aged rats with myocardial infarction |
| title_full_unstemmed | Experimental study of partially oxidized sodium alginate gel combined with myogenic stem cells to improve cardiac function in aged rats with myocardial infarction |
| title_short | Experimental study of partially oxidized sodium alginate gel combined with myogenic stem cells to improve cardiac function in aged rats with myocardial infarction |
| title_sort | experimental study of partially oxidized sodium alginate gel combined with myogenic stem cells to improve cardiac function in aged rats with myocardial infarction |
| topic | sodium alginate myogenic stem cells aged rats myocardial infarction cardiac function ventricular remodeling |
| url | http://gwll.publish.founderss.cn/thesisDetails#10.3969/j.issn.1674-7593.2025.01.003&lang=en |
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