Sjögren Syndrome Complicated with Cystic Lung Disease and Pulmonary Amyloidosis
A 72-year-old Japanese woman was noted to have multiple cystic lung shadows and infiltrates on chest radiography and computed tomography (CT). She complained of dryness of the mouth and eyes, but she did not have respiratory symptoms, such as cough, sputum production, and dyspnea. Her laboratory fin...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Rheumatology |
| Online Access: | http://dx.doi.org/10.1155/2018/7475242 |
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| author | Koichiro Takahashi Hironori Sadamatsu Shinsuke Ogusu Kazutoshi Komiya Tomomi Nakamura Shinya Kimura Naoko Sueoka-Aragane |
| author_facet | Koichiro Takahashi Hironori Sadamatsu Shinsuke Ogusu Kazutoshi Komiya Tomomi Nakamura Shinya Kimura Naoko Sueoka-Aragane |
| author_sort | Koichiro Takahashi |
| collection | DOAJ |
| description | A 72-year-old Japanese woman was noted to have multiple cystic lung shadows and infiltrates on chest radiography and computed tomography (CT). She complained of dryness of the mouth and eyes, but she did not have respiratory symptoms, such as cough, sputum production, and dyspnea. Her laboratory findings showed high titers of anti-SSA/Ro and anti-SSB/La antibodies. Surgical lung biopsy was performed and demonstrated pathologic findings of amyloid light-chain deposition and bronchiolitis with lymphocytic infiltration. Taken altogether, she was diagnosed as Sjögren syndrome with bronchiolitis and pulmonary amyloidosis. Since then, she has been carefully followed up without treatment. After 6 years, the cystic lung lesions on CT gradually enlarged and increased in number, but she remained to have no respiratory symptoms and no manifestations of lymphoma. Here, we report a rare case of Sjögren syndrome complicated with cystic lung disease and pulmonary amyloidosis. |
| format | Article |
| id | doaj-art-ed4fb3d043cd4088a4f2be4de8e86e3d |
| institution | Kabale University |
| issn | 2090-6889 2090-6897 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Rheumatology |
| spelling | doaj-art-ed4fb3d043cd4088a4f2be4de8e86e3d2025-02-03T01:02:09ZengWileyCase Reports in Rheumatology2090-68892090-68972018-01-01201810.1155/2018/74752427475242Sjögren Syndrome Complicated with Cystic Lung Disease and Pulmonary AmyloidosisKoichiro Takahashi0Hironori Sadamatsu1Shinsuke Ogusu2Kazutoshi Komiya3Tomomi Nakamura4Shinya Kimura5Naoko Sueoka-Aragane6Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, JapanDivision of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, JapanDivision of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, JapanDivision of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, JapanDivision of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, JapanDivision of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, JapanDivision of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, JapanA 72-year-old Japanese woman was noted to have multiple cystic lung shadows and infiltrates on chest radiography and computed tomography (CT). She complained of dryness of the mouth and eyes, but she did not have respiratory symptoms, such as cough, sputum production, and dyspnea. Her laboratory findings showed high titers of anti-SSA/Ro and anti-SSB/La antibodies. Surgical lung biopsy was performed and demonstrated pathologic findings of amyloid light-chain deposition and bronchiolitis with lymphocytic infiltration. Taken altogether, she was diagnosed as Sjögren syndrome with bronchiolitis and pulmonary amyloidosis. Since then, she has been carefully followed up without treatment. After 6 years, the cystic lung lesions on CT gradually enlarged and increased in number, but she remained to have no respiratory symptoms and no manifestations of lymphoma. Here, we report a rare case of Sjögren syndrome complicated with cystic lung disease and pulmonary amyloidosis.http://dx.doi.org/10.1155/2018/7475242 |
| spellingShingle | Koichiro Takahashi Hironori Sadamatsu Shinsuke Ogusu Kazutoshi Komiya Tomomi Nakamura Shinya Kimura Naoko Sueoka-Aragane Sjögren Syndrome Complicated with Cystic Lung Disease and Pulmonary Amyloidosis Case Reports in Rheumatology |
| title | Sjögren Syndrome Complicated with Cystic Lung Disease and Pulmonary Amyloidosis |
| title_full | Sjögren Syndrome Complicated with Cystic Lung Disease and Pulmonary Amyloidosis |
| title_fullStr | Sjögren Syndrome Complicated with Cystic Lung Disease and Pulmonary Amyloidosis |
| title_full_unstemmed | Sjögren Syndrome Complicated with Cystic Lung Disease and Pulmonary Amyloidosis |
| title_short | Sjögren Syndrome Complicated with Cystic Lung Disease and Pulmonary Amyloidosis |
| title_sort | sjogren syndrome complicated with cystic lung disease and pulmonary amyloidosis |
| url | http://dx.doi.org/10.1155/2018/7475242 |
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