Anti-Tumor Effects of <i>Vespa bicolor</i> Venom on Liver Cancer: In Vitro and In Vivo Studies
Despite the popular belief in the anti-tumor properties of <i>Vespa bicolor</i> venom (VBV), there is limited scientific evidence to support this claim. This study is the first to examine the anti-tumor effects of VBV on liver cancer, both alone and in combination with cisplatin (DDP), t...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-12-01
|
| Series: | Toxins |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6651/17/1/4 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832587466685546496 |
|---|---|
| author | Yong-Hua Wu Feng Xiong Zheng-Wen Ou Jing-An Wang Jing Cui Lin Jiang Wen-Jian Lan |
| author_facet | Yong-Hua Wu Feng Xiong Zheng-Wen Ou Jing-An Wang Jing Cui Lin Jiang Wen-Jian Lan |
| author_sort | Yong-Hua Wu |
| collection | DOAJ |
| description | Despite the popular belief in the anti-tumor properties of <i>Vespa bicolor</i> venom (VBV), there is limited scientific evidence to support this claim. This study is the first to examine the anti-tumor effects of VBV on liver cancer, both alone and in combination with cisplatin (DDP), through in vitro and in vivo experiments. In vitro experiments evaluated VBV and its combination with DDP on HepG2 cell proliferation, invasion, migration, and apoptosis. Animal studies examined the tumor-suppressive effects, safety (hepatotoxicity and nephrotoxicity), and immune impact of these treatments in tumor-bearing mice. VBV monotherapy significantly inhibited the growth of HepG2 cells by suppressing their proliferation and invasion and induced apoptosis in vitro. Notably, low VBV concentrations significantly promoted the proliferation of normal liver cells (L-02), suggesting a hepatoprotective effect. In vivo, VBV monotherapy enhanced immune function and exhibited tumor suppression comparable to DDP monotherapy but did not induce significant liver or kidney damage. In addition, VBV combined with DDP synergistically enhanced the anti-tumor effects of DDP, compensating for its limited apoptosis-inducing activity and insufficient enhancement of immune function. Initial studies have shown the strong potential of VBV as an anti-liver-tumor drug, highlighting its unique clinical value. |
| format | Article |
| id | doaj-art-ed496482d2e34c4f89b1a5eda4d0a080 |
| institution | Kabale University |
| issn | 2072-6651 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj-art-ed496482d2e34c4f89b1a5eda4d0a0802025-01-24T13:51:09ZengMDPI AGToxins2072-66512024-12-01171410.3390/toxins17010004Anti-Tumor Effects of <i>Vespa bicolor</i> Venom on Liver Cancer: In Vitro and In Vivo StudiesYong-Hua Wu0Feng Xiong1Zheng-Wen Ou2Jing-An Wang3Jing Cui4Lin Jiang5Wen-Jian Lan6School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, ChinaSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, ChinaProduction and Research Base for Wasp Deinsectization, Huxin Biotechnology Co., Ltd., Jiangmen 529245, ChinaProduction and Research Base for Wasp Deinsectization, Huxin Biotechnology Co., Ltd., Jiangmen 529245, ChinaProduction and Research Base for Wasp Deinsectization, Huxin Biotechnology Co., Ltd., Jiangmen 529245, ChinaSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, ChinaSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, ChinaDespite the popular belief in the anti-tumor properties of <i>Vespa bicolor</i> venom (VBV), there is limited scientific evidence to support this claim. This study is the first to examine the anti-tumor effects of VBV on liver cancer, both alone and in combination with cisplatin (DDP), through in vitro and in vivo experiments. In vitro experiments evaluated VBV and its combination with DDP on HepG2 cell proliferation, invasion, migration, and apoptosis. Animal studies examined the tumor-suppressive effects, safety (hepatotoxicity and nephrotoxicity), and immune impact of these treatments in tumor-bearing mice. VBV monotherapy significantly inhibited the growth of HepG2 cells by suppressing their proliferation and invasion and induced apoptosis in vitro. Notably, low VBV concentrations significantly promoted the proliferation of normal liver cells (L-02), suggesting a hepatoprotective effect. In vivo, VBV monotherapy enhanced immune function and exhibited tumor suppression comparable to DDP monotherapy but did not induce significant liver or kidney damage. In addition, VBV combined with DDP synergistically enhanced the anti-tumor effects of DDP, compensating for its limited apoptosis-inducing activity and insufficient enhancement of immune function. Initial studies have shown the strong potential of VBV as an anti-liver-tumor drug, highlighting its unique clinical value.https://www.mdpi.com/2072-6651/17/1/4<i>V. bicolor</i> Fabriciusvenomanti-tumor evaluationmonotherapycombination therapy |
| spellingShingle | Yong-Hua Wu Feng Xiong Zheng-Wen Ou Jing-An Wang Jing Cui Lin Jiang Wen-Jian Lan Anti-Tumor Effects of <i>Vespa bicolor</i> Venom on Liver Cancer: In Vitro and In Vivo Studies Toxins <i>V. bicolor</i> Fabricius venom anti-tumor evaluation monotherapy combination therapy |
| title | Anti-Tumor Effects of <i>Vespa bicolor</i> Venom on Liver Cancer: In Vitro and In Vivo Studies |
| title_full | Anti-Tumor Effects of <i>Vespa bicolor</i> Venom on Liver Cancer: In Vitro and In Vivo Studies |
| title_fullStr | Anti-Tumor Effects of <i>Vespa bicolor</i> Venom on Liver Cancer: In Vitro and In Vivo Studies |
| title_full_unstemmed | Anti-Tumor Effects of <i>Vespa bicolor</i> Venom on Liver Cancer: In Vitro and In Vivo Studies |
| title_short | Anti-Tumor Effects of <i>Vespa bicolor</i> Venom on Liver Cancer: In Vitro and In Vivo Studies |
| title_sort | anti tumor effects of i vespa bicolor i venom on liver cancer in vitro and in vivo studies |
| topic | <i>V. bicolor</i> Fabricius venom anti-tumor evaluation monotherapy combination therapy |
| url | https://www.mdpi.com/2072-6651/17/1/4 |
| work_keys_str_mv | AT yonghuawu antitumoreffectsofivespabicolorivenomonlivercancerinvitroandinvivostudies AT fengxiong antitumoreffectsofivespabicolorivenomonlivercancerinvitroandinvivostudies AT zhengwenou antitumoreffectsofivespabicolorivenomonlivercancerinvitroandinvivostudies AT jinganwang antitumoreffectsofivespabicolorivenomonlivercancerinvitroandinvivostudies AT jingcui antitumoreffectsofivespabicolorivenomonlivercancerinvitroandinvivostudies AT linjiang antitumoreffectsofivespabicolorivenomonlivercancerinvitroandinvivostudies AT wenjianlan antitumoreffectsofivespabicolorivenomonlivercancerinvitroandinvivostudies |