Amoebic Liver Abscess and Indigenous Alcoholic Beverages in the Tropics
Amoebic liver abscess (ALA) seen commonly in the tropics is predominantly confined to adult males, especially those who consume locally brewed alcohol, although intestinal amoebiasis occurs in all age groups and in both genders. Whether the role of alcohol in the development of ALA is incidental and...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Tropical Medicine |
| Online Access: | http://dx.doi.org/10.1155/2018/6901751 |
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| author | T. Kumanan V. Sujanitha S. Balakumar N. Sreeharan |
| author_facet | T. Kumanan V. Sujanitha S. Balakumar N. Sreeharan |
| author_sort | T. Kumanan |
| collection | DOAJ |
| description | Amoebic liver abscess (ALA) seen commonly in the tropics is predominantly confined to adult males, especially those who consume locally brewed alcohol, although intestinal amoebiasis occurs in all age groups and in both genders. Whether the role of alcohol in the development of ALA is incidental and casual or whether alcohol is causally implicated has been debated. It has been argued that socioeconomic factors and poor sanitary conditions are the primary culprits that casually link alcohol to ALA. However, there has emerged an abundance of data that implicates alcohol in a more causal role in facilitating the extraintestinal invasion of the infective protozoan and the subsequent development of ALA. These factors include the role of alcohol in host immunity, parasitic proliferation, and invasion and in creating a conducive hepatic microenvironment. The contributory role of alcohol-induced increase in hepatic iron stores and lipid content is discussed. Late-stage liver disease with fibrosis seems to be protective for the development of ALA. Further research is necessary to elucidate the many possible mechanisms that predispose to hepatic amoebiasis, so that appropriate individual and population-based preventive measures can be implemented. |
| format | Article |
| id | doaj-art-ed39d3e0042540ab81cab98de08186f2 |
| institution | Kabale University |
| issn | 1687-9686 1687-9694 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Tropical Medicine |
| spelling | doaj-art-ed39d3e0042540ab81cab98de08186f22025-02-03T06:11:30ZengWileyJournal of Tropical Medicine1687-96861687-96942018-01-01201810.1155/2018/69017516901751Amoebic Liver Abscess and Indigenous Alcoholic Beverages in the TropicsT. Kumanan0V. Sujanitha1S. Balakumar2N. Sreeharan3Department of Medicine, Faculty of Medicine, University of Jaffna, Jaffna, Sri LankaDepartment of Medicine, Faculty of Medicine, University of Jaffna, Jaffna, Sri LankaDepartment of Biochemistry, Faculty of Medicine, University of Jaffna, Jaffna, Sri LankaDepartment of Medicine, Faculty of Medicine, University of Jaffna, Jaffna, Sri LankaAmoebic liver abscess (ALA) seen commonly in the tropics is predominantly confined to adult males, especially those who consume locally brewed alcohol, although intestinal amoebiasis occurs in all age groups and in both genders. Whether the role of alcohol in the development of ALA is incidental and casual or whether alcohol is causally implicated has been debated. It has been argued that socioeconomic factors and poor sanitary conditions are the primary culprits that casually link alcohol to ALA. However, there has emerged an abundance of data that implicates alcohol in a more causal role in facilitating the extraintestinal invasion of the infective protozoan and the subsequent development of ALA. These factors include the role of alcohol in host immunity, parasitic proliferation, and invasion and in creating a conducive hepatic microenvironment. The contributory role of alcohol-induced increase in hepatic iron stores and lipid content is discussed. Late-stage liver disease with fibrosis seems to be protective for the development of ALA. Further research is necessary to elucidate the many possible mechanisms that predispose to hepatic amoebiasis, so that appropriate individual and population-based preventive measures can be implemented.http://dx.doi.org/10.1155/2018/6901751 |
| spellingShingle | T. Kumanan V. Sujanitha S. Balakumar N. Sreeharan Amoebic Liver Abscess and Indigenous Alcoholic Beverages in the Tropics Journal of Tropical Medicine |
| title | Amoebic Liver Abscess and Indigenous Alcoholic Beverages in the Tropics |
| title_full | Amoebic Liver Abscess and Indigenous Alcoholic Beverages in the Tropics |
| title_fullStr | Amoebic Liver Abscess and Indigenous Alcoholic Beverages in the Tropics |
| title_full_unstemmed | Amoebic Liver Abscess and Indigenous Alcoholic Beverages in the Tropics |
| title_short | Amoebic Liver Abscess and Indigenous Alcoholic Beverages in the Tropics |
| title_sort | amoebic liver abscess and indigenous alcoholic beverages in the tropics |
| url | http://dx.doi.org/10.1155/2018/6901751 |
| work_keys_str_mv | AT tkumanan amoebicliverabscessandindigenousalcoholicbeveragesinthetropics AT vsujanitha amoebicliverabscessandindigenousalcoholicbeveragesinthetropics AT sbalakumar amoebicliverabscessandindigenousalcoholicbeveragesinthetropics AT nsreeharan amoebicliverabscessandindigenousalcoholicbeveragesinthetropics |