Cross-ancestry genome-wide association study identifies implications of SORL1 in cerebral beta-amyloid deposition

Cross-ancestry genome-wide association study identifies implications of SORL1 in cerebral beta-amyloid deposition

Abstract GWAS of Alzheimer’s disease have been predominantly based on European ancestry cohorts with clinically diagnosed patients. Increasing the ancestral diversity of GWAS and focusing on imaging brain biomarkers for Alzheimer’s disease may lead to the identification of new genetic loci. Here, we...

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Main Authors: Jun Pyo Kim, Sang-Hyuk Jung, Beomjin Jang, Minyoung Cho, Minku Song, Jaeyoung Kim, Beomsu Kim, Hyunwoo Lee, Daeun Shin, Eun Hye Lee, Hyemin Jang, Bo-Hyun Kim, Hongki Ham, Dokyoon Kim, Towfique Raj, Carlos Cruchaga, Hee Jin Kim, Duk L. Na, Sang Won Seo, Hong-Hee Won
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57751-4
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