Genetic association study of TERT gene variants with chronic kidney disease susceptibility in the Chinese population
The incidence and mortality of chronic kidney disease (CKD) are increasing globally. Studies have demonstrated the significance of genetic risk factors in the progression of CKD. Telomerase reverse transcriptase (TERT) may be implicated in the development of CKD. This study aimed to investigate the...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
|
| Series: | Renal Failure |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2300725 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832591137124122624 |
|---|---|
| author | Yan Su Yuan Feng Xinran Lin Chunyang Ma Jiali Wei |
| author_facet | Yan Su Yuan Feng Xinran Lin Chunyang Ma Jiali Wei |
| author_sort | Yan Su |
| collection | DOAJ |
| description | The incidence and mortality of chronic kidney disease (CKD) are increasing globally. Studies have demonstrated the significance of genetic risk factors in the progression of CKD. Telomerase reverse transcriptase (TERT) may be implicated in the development of CKD. This study aimed to investigate the correlation between TERT gene variants and susceptibility to CKD in the Chinese population. A total of 507 patients with CKD and 510 healthy controls were recruited for this case-control study. Four candidate loci were identified using the MassARRAY platform. Logistic regression analysis was employed to assess the association between TERT gene variants and the risk of CKD. The false positive reporting probability (FPRP) method was utilized to evaluate the validity of statistically significant associations. The multifactorial dimensionality reduction (MDR) method was used to evaluate the interaction between SNPs and the risk of CKD. Furthermore, discrepancies in the clinical features of subjects with diverse genotypes were evaluated using one-way analysis of variance (ANOVA). Our findings revealed a correlation between rs2735940 and rs4635969 and an increased risk of CKD. Stratification analysis indicated that rs4635969 was related to an increased risk of CKD in different subgroups (age ≤ 50 years and male). MDR analysis indicated that the two-site model (rs2735940 and rs4635969) was the best prediction model. Furthermore, the rs2735940 GG genotype was found to be linked to an increased level of microalbuminuria (MAU) in patients with CKD. Our study is the first to reveal a connection between TERT gene variants and susceptibility to CKD, providing new insights into the field of nephrology. |
| format | Article |
| id | doaj-art-ed2431b67bba4819a371e0e91cde0fc8 |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-ed2431b67bba4819a371e0e91cde0fc82025-01-23T04:17:47ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146110.1080/0886022X.2023.2300725Genetic association study of TERT gene variants with chronic kidney disease susceptibility in the Chinese populationYan Su0Yuan Feng1Xinran Lin2Chunyang Ma3Jiali Wei4Department of Nephrology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, PR ChinaDepartment of Immunology, the Affiliated Children’s Hospital of Xi’an Jiaotong University, Xi’an, PR ChinaDepartment of Nephrology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, PR ChinaDepartment of Neurosurgery, the First Affiliated Hospital of Hainan Medical College, Haikou, PR ChinaDepartment of Nephrology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, PR ChinaThe incidence and mortality of chronic kidney disease (CKD) are increasing globally. Studies have demonstrated the significance of genetic risk factors in the progression of CKD. Telomerase reverse transcriptase (TERT) may be implicated in the development of CKD. This study aimed to investigate the correlation between TERT gene variants and susceptibility to CKD in the Chinese population. A total of 507 patients with CKD and 510 healthy controls were recruited for this case-control study. Four candidate loci were identified using the MassARRAY platform. Logistic regression analysis was employed to assess the association between TERT gene variants and the risk of CKD. The false positive reporting probability (FPRP) method was utilized to evaluate the validity of statistically significant associations. The multifactorial dimensionality reduction (MDR) method was used to evaluate the interaction between SNPs and the risk of CKD. Furthermore, discrepancies in the clinical features of subjects with diverse genotypes were evaluated using one-way analysis of variance (ANOVA). Our findings revealed a correlation between rs2735940 and rs4635969 and an increased risk of CKD. Stratification analysis indicated that rs4635969 was related to an increased risk of CKD in different subgroups (age ≤ 50 years and male). MDR analysis indicated that the two-site model (rs2735940 and rs4635969) was the best prediction model. Furthermore, the rs2735940 GG genotype was found to be linked to an increased level of microalbuminuria (MAU) in patients with CKD. Our study is the first to reveal a connection between TERT gene variants and susceptibility to CKD, providing new insights into the field of nephrology.https://www.tandfonline.com/doi/10.1080/0886022X.2023.2300725Chronic kidney diseasegenetic association studyTERTgene variants |
| spellingShingle | Yan Su Yuan Feng Xinran Lin Chunyang Ma Jiali Wei Genetic association study of TERT gene variants with chronic kidney disease susceptibility in the Chinese population Renal Failure Chronic kidney disease genetic association study TERT gene variants |
| title | Genetic association study of TERT gene variants with chronic kidney disease susceptibility in the Chinese population |
| title_full | Genetic association study of TERT gene variants with chronic kidney disease susceptibility in the Chinese population |
| title_fullStr | Genetic association study of TERT gene variants with chronic kidney disease susceptibility in the Chinese population |
| title_full_unstemmed | Genetic association study of TERT gene variants with chronic kidney disease susceptibility in the Chinese population |
| title_short | Genetic association study of TERT gene variants with chronic kidney disease susceptibility in the Chinese population |
| title_sort | genetic association study of tert gene variants with chronic kidney disease susceptibility in the chinese population |
| topic | Chronic kidney disease genetic association study TERT gene variants |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2300725 |
| work_keys_str_mv | AT yansu geneticassociationstudyoftertgenevariantswithchronickidneydiseasesusceptibilityinthechinesepopulation AT yuanfeng geneticassociationstudyoftertgenevariantswithchronickidneydiseasesusceptibilityinthechinesepopulation AT xinranlin geneticassociationstudyoftertgenevariantswithchronickidneydiseasesusceptibilityinthechinesepopulation AT chunyangma geneticassociationstudyoftertgenevariantswithchronickidneydiseasesusceptibilityinthechinesepopulation AT jialiwei geneticassociationstudyoftertgenevariantswithchronickidneydiseasesusceptibilityinthechinesepopulation |