Antimicrobial activity and mechanisms of action of Origanum vulgare L. essential oil: effects on membrane-associated properties
Historically, essential oils (Eos) have been applied in diverse ways, with modern science confirming their antimicrobial, antioxidant, anti-inflammatory, and neuroprotective properties. Origanum vulgare (oregano) is a notable source of EOs, being particularly rich in compounds like thymol, carvacrol...
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AIMS Press
2024-11-01
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| Series: | AIMS Biophysics |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/biophy.2024027 |
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| author | Armenuhi Moghrovyan Naira Sahakyan |
| author_facet | Armenuhi Moghrovyan Naira Sahakyan |
| author_sort | Armenuhi Moghrovyan |
| collection | DOAJ |
| description | Historically, essential oils (Eos) have been applied in diverse ways, with modern science confirming their antimicrobial, antioxidant, anti-inflammatory, and neuroprotective properties. Origanum vulgare (oregano) is a notable source of EOs, being particularly rich in compounds like thymol, carvacrol, and β-caryophyllene, which contribute to its potent antibacterial effects. These include disruption of bacterial cell membranes, interference with quorum sensing, and inhibition of biofilm formation. Oregano EO has shown effectiveness against both antibiotic-resistant and non-resistant bacterial strains, such as Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. The components of this EO disrupt membrane integrity, ion transport, membrane surface charge, biofilm formation, and other biophysical parameters, eventually leading to cell death. Research highlights its potential in combatting antibiotic resistance, either alone or in synergy with traditional antibiotics. Additionally, oregano EO holds promise as a natural therapeutic agent. Continued study of its complex chemical interactions will further elucidate its full potential in antimicrobial therapy. This review article presents the possible mechanisms of the antimicrobial action of oregano essential oil and its application prospects. |
| format | Article |
| id | doaj-art-ed0f1e494dec4babbc21f99a88b72d19 |
| institution | Kabale University |
| issn | 2377-9098 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | AIMS Biophysics |
| spelling | doaj-art-ed0f1e494dec4babbc21f99a88b72d192025-01-24T01:20:10ZengAIMS PressAIMS Biophysics2377-90982024-11-0111450852610.3934/biophy.2024027Antimicrobial activity and mechanisms of action of Origanum vulgare L. essential oil: effects on membrane-associated propertiesArmenuhi Moghrovyan0Naira Sahakyan1Department of Pharmacognosy, Yerevan State Medical University after M. Heratsi, Koryun 2, Yerevan, 0025, RADepartment of Biochemistry, Microbiology and Biotechnology, Yerevan State University, A. Manoogian 1, Yerevan, 0025, RAHistorically, essential oils (Eos) have been applied in diverse ways, with modern science confirming their antimicrobial, antioxidant, anti-inflammatory, and neuroprotective properties. Origanum vulgare (oregano) is a notable source of EOs, being particularly rich in compounds like thymol, carvacrol, and β-caryophyllene, which contribute to its potent antibacterial effects. These include disruption of bacterial cell membranes, interference with quorum sensing, and inhibition of biofilm formation. Oregano EO has shown effectiveness against both antibiotic-resistant and non-resistant bacterial strains, such as Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. The components of this EO disrupt membrane integrity, ion transport, membrane surface charge, biofilm formation, and other biophysical parameters, eventually leading to cell death. Research highlights its potential in combatting antibiotic resistance, either alone or in synergy with traditional antibiotics. Additionally, oregano EO holds promise as a natural therapeutic agent. Continued study of its complex chemical interactions will further elucidate its full potential in antimicrobial therapy. This review article presents the possible mechanisms of the antimicrobial action of oregano essential oil and its application prospects.https://www.aimspress.com/article/doi/10.3934/biophy.2024027origanum vulgaresecondary metabolitesmembrane surface chargeproton fluxesbiofilmcell membrane biophysical properties |
| spellingShingle | Armenuhi Moghrovyan Naira Sahakyan Antimicrobial activity and mechanisms of action of Origanum vulgare L. essential oil: effects on membrane-associated properties AIMS Biophysics origanum vulgare secondary metabolites membrane surface charge proton fluxes biofilm cell membrane biophysical properties |
| title | Antimicrobial activity and mechanisms of action of Origanum vulgare L. essential oil: effects on membrane-associated properties |
| title_full | Antimicrobial activity and mechanisms of action of Origanum vulgare L. essential oil: effects on membrane-associated properties |
| title_fullStr | Antimicrobial activity and mechanisms of action of Origanum vulgare L. essential oil: effects on membrane-associated properties |
| title_full_unstemmed | Antimicrobial activity and mechanisms of action of Origanum vulgare L. essential oil: effects on membrane-associated properties |
| title_short | Antimicrobial activity and mechanisms of action of Origanum vulgare L. essential oil: effects on membrane-associated properties |
| title_sort | antimicrobial activity and mechanisms of action of origanum vulgare l essential oil effects on membrane associated properties |
| topic | origanum vulgare secondary metabolites membrane surface charge proton fluxes biofilm cell membrane biophysical properties |
| url | https://www.aimspress.com/article/doi/10.3934/biophy.2024027 |
| work_keys_str_mv | AT armenuhimoghrovyan antimicrobialactivityandmechanismsofactionoforiganumvulgarelessentialoileffectsonmembraneassociatedproperties AT nairasahakyan antimicrobialactivityandmechanismsofactionoforiganumvulgarelessentialoileffectsonmembraneassociatedproperties |