Genomic characterization of Escherichia coli with a polyketide synthase (pks) island isolated from ulcerative colitis patients

Genomic characterization of Escherichia coli with a polyketide synthase (pks) island isolated from ulcerative colitis patients

Abstract The E. coli strains harboring the polyketide synthase (pks) island encode the genotoxin colibactin, a secondary metabolite reported to have severe implications for human health and for the progression of colorectal cancer. The present study involves whole-genome-wide comparison and phylogen...

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Main Authors: Chao Lv, Mohd Abdullah, Chun-Li Su, Weiye Chen, Nan Zhou, Zile Cheng, Yiwen Chen, Min Li, Kenneth W. Simpson, Ahmed Elsaadi, Yongzhang Zhu, Steven M. Lipkin, Yung-Fu Chang
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Genomics
Subjects:
Colibactin
Colorectal cancer
Genome sequencing
Phylogenetics
Online Access:https://doi.org/10.1186/s12864-024-11198-x
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