Retrospective Review of Loop Electrosurgical Excision Procedure (LEEP) Outcomes at a Tertiary Hospital in Zambia
There is a lack of knowledge on the histologic outcomes of loop electrosurgical excision procedure (LEEP) biopsies in the diagnosis, treatment, and prevention of cervical cancer in Zambia. This study determined the outcomes of LEEP biopsies and associated factors at a tertiary hospital. We conducted...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Obstetrics and Gynecology International |
| Online Access: | http://dx.doi.org/10.1155/2020/1920218 |
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| author | Nancy Kasongo Chiza Kasungu Nixon Miyoba Herbert T. Nyirenda Muleta Kumoyo |
| author_facet | Nancy Kasongo Chiza Kasungu Nixon Miyoba Herbert T. Nyirenda Muleta Kumoyo |
| author_sort | Nancy Kasongo |
| collection | DOAJ |
| description | There is a lack of knowledge on the histologic outcomes of loop electrosurgical excision procedure (LEEP) biopsies in the diagnosis, treatment, and prevention of cervical cancer in Zambia. This study determined the outcomes of LEEP biopsies and associated factors at a tertiary hospital. We conducted a retrospective chart review of patients evaluated at a tertiary hospital cervical cancer screening centre. From the database, we identified patients who underwent LEEP between January 2015 and June 2018. We extracted demographic data, HIV data, and LEEP biopsy results. A P value less than 0.05 was considered statistically significant. 137 charts were identified, and 114 were included in the final analysis. 23 were excluded for missing histology. The mean age of participants was 36.3 ± 9.6. Histology outcomes revealed that 37% had cervicitis, while CIN 1, 2, and 3 contributed to 27%, 14%, and 3%, respectively. Squamous cell cancer was present in 8% (age groups 35–49) and was three times higher (13%) in HIV-positive compared to HIV-negative participants (3.8%). Normal histology accounted for 11%. Increasing age (P=0.029), less than tertiary education (P=0.0011), and being married (P=0.017) increased the chances of having cancer in the chi-square analysis, while single women had lower odds of having CIN 1 (OR = 0.012) in the multinomial logistic regression. There is a need for increased cervical cancer screening and training in precancer treatment and holistic consideration of other factors like age in addition to the positive VIA test in advising patients on treatment options. |
| format | Article |
| id | doaj-art-ed025f26a4ac42d6b76e589fad0c608a |
| institution | Kabale University |
| issn | 1687-9589 1687-9597 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
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| series | Obstetrics and Gynecology International |
| spelling | doaj-art-ed025f26a4ac42d6b76e589fad0c608a2025-02-03T06:06:29ZengWileyObstetrics and Gynecology International1687-95891687-95972020-01-01202010.1155/2020/19202181920218Retrospective Review of Loop Electrosurgical Excision Procedure (LEEP) Outcomes at a Tertiary Hospital in ZambiaNancy Kasongo0Chiza Kasungu1Nixon Miyoba2Herbert T. Nyirenda3Muleta Kumoyo4School of Medicine, The Copperbelt University, Ndola 10101, ZambiaSchool of Medicine, The Copperbelt University, Ndola 10101, ZambiaUniversity of Zambia, Lusaka 10101, ZambiaSchool of Medicine, The Copperbelt University, Ndola 10101, ZambiaDepartment of Obstetrics and Gynecology, Ndola Teaching Hospital, Ndola 10101, ZambiaThere is a lack of knowledge on the histologic outcomes of loop electrosurgical excision procedure (LEEP) biopsies in the diagnosis, treatment, and prevention of cervical cancer in Zambia. This study determined the outcomes of LEEP biopsies and associated factors at a tertiary hospital. We conducted a retrospective chart review of patients evaluated at a tertiary hospital cervical cancer screening centre. From the database, we identified patients who underwent LEEP between January 2015 and June 2018. We extracted demographic data, HIV data, and LEEP biopsy results. A P value less than 0.05 was considered statistically significant. 137 charts were identified, and 114 were included in the final analysis. 23 were excluded for missing histology. The mean age of participants was 36.3 ± 9.6. Histology outcomes revealed that 37% had cervicitis, while CIN 1, 2, and 3 contributed to 27%, 14%, and 3%, respectively. Squamous cell cancer was present in 8% (age groups 35–49) and was three times higher (13%) in HIV-positive compared to HIV-negative participants (3.8%). Normal histology accounted for 11%. Increasing age (P=0.029), less than tertiary education (P=0.0011), and being married (P=0.017) increased the chances of having cancer in the chi-square analysis, while single women had lower odds of having CIN 1 (OR = 0.012) in the multinomial logistic regression. There is a need for increased cervical cancer screening and training in precancer treatment and holistic consideration of other factors like age in addition to the positive VIA test in advising patients on treatment options.http://dx.doi.org/10.1155/2020/1920218 |
| spellingShingle | Nancy Kasongo Chiza Kasungu Nixon Miyoba Herbert T. Nyirenda Muleta Kumoyo Retrospective Review of Loop Electrosurgical Excision Procedure (LEEP) Outcomes at a Tertiary Hospital in Zambia Obstetrics and Gynecology International |
| title | Retrospective Review of Loop Electrosurgical Excision Procedure (LEEP) Outcomes at a Tertiary Hospital in Zambia |
| title_full | Retrospective Review of Loop Electrosurgical Excision Procedure (LEEP) Outcomes at a Tertiary Hospital in Zambia |
| title_fullStr | Retrospective Review of Loop Electrosurgical Excision Procedure (LEEP) Outcomes at a Tertiary Hospital in Zambia |
| title_full_unstemmed | Retrospective Review of Loop Electrosurgical Excision Procedure (LEEP) Outcomes at a Tertiary Hospital in Zambia |
| title_short | Retrospective Review of Loop Electrosurgical Excision Procedure (LEEP) Outcomes at a Tertiary Hospital in Zambia |
| title_sort | retrospective review of loop electrosurgical excision procedure leep outcomes at a tertiary hospital in zambia |
| url | http://dx.doi.org/10.1155/2020/1920218 |
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