Oxidative Stress-Induced Diseases via the ASK1 Signaling Pathway
Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase (MAPK) kinase kinase that activates the downstream MAPKs, c-Jun N-terminal kinase (JNK) and p38. ASK1 is activated by various types of stress, such as oxidative stress, endoplasmic reticulum stress, and infection, and...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2012/439587 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832564022137847808 |
|---|---|
| author | Mayumi Soga Atsushi Matsuzawa Hidenori Ichijo |
| author_facet | Mayumi Soga Atsushi Matsuzawa Hidenori Ichijo |
| author_sort | Mayumi Soga |
| collection | DOAJ |
| description | Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase (MAPK) kinase kinase that activates the downstream MAPKs, c-Jun N-terminal kinase (JNK) and p38. ASK1 is activated by various types of stress, such as oxidative stress, endoplasmic reticulum stress, and infection, and regulates various cellular functions. Recently, it has been reported that ASK1 is associated with various diseases induced by oxidative stress. In this review, we introduce recent findings of the regulatory mechanisms of ASK1 and the oxidative stress-induced diseases mediated by the ASK1 signaling pathway. |
| format | Article |
| id | doaj-art-ecfdb519b1574783a21200fa046896c5 |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-ecfdb519b1574783a21200fa046896c52025-02-03T01:12:07ZengWileyInternational Journal of Cell Biology1687-88761687-88842012-01-01201210.1155/2012/439587439587Oxidative Stress-Induced Diseases via the ASK1 Signaling PathwayMayumi Soga0Atsushi Matsuzawa1Hidenori Ichijo2Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, JapanLaboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, JapanLaboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, JapanApoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase (MAPK) kinase kinase that activates the downstream MAPKs, c-Jun N-terminal kinase (JNK) and p38. ASK1 is activated by various types of stress, such as oxidative stress, endoplasmic reticulum stress, and infection, and regulates various cellular functions. Recently, it has been reported that ASK1 is associated with various diseases induced by oxidative stress. In this review, we introduce recent findings of the regulatory mechanisms of ASK1 and the oxidative stress-induced diseases mediated by the ASK1 signaling pathway.http://dx.doi.org/10.1155/2012/439587 |
| spellingShingle | Mayumi Soga Atsushi Matsuzawa Hidenori Ichijo Oxidative Stress-Induced Diseases via the ASK1 Signaling Pathway International Journal of Cell Biology |
| title | Oxidative Stress-Induced Diseases via the ASK1 Signaling Pathway |
| title_full | Oxidative Stress-Induced Diseases via the ASK1 Signaling Pathway |
| title_fullStr | Oxidative Stress-Induced Diseases via the ASK1 Signaling Pathway |
| title_full_unstemmed | Oxidative Stress-Induced Diseases via the ASK1 Signaling Pathway |
| title_short | Oxidative Stress-Induced Diseases via the ASK1 Signaling Pathway |
| title_sort | oxidative stress induced diseases via the ask1 signaling pathway |
| url | http://dx.doi.org/10.1155/2012/439587 |
| work_keys_str_mv | AT mayumisoga oxidativestressinduceddiseasesviatheask1signalingpathway AT atsushimatsuzawa oxidativestressinduceddiseasesviatheask1signalingpathway AT hidenoriichijo oxidativestressinduceddiseasesviatheask1signalingpathway |