Assessment of the Severity of Intermediate Coronary Artery Stenosis Using the Systemic Inflammatory Response Index
<b>Background</b>: Fractional Flow Reserve (FFR) is a method that enables the hemodynamic assessment of coronary artery stenosis. The Systemic Inflammatory Response Index (SIRI) is a new marker calculated by multiplying the neutrophil-to-lymphocyte ratio (NLR) with the monocyte count. It...
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MDPI AG
2025-01-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/15/2/162 |
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| author | Serdar Akyel Ahmet Korkmaz Abdülkadir Yıldız |
| author_facet | Serdar Akyel Ahmet Korkmaz Abdülkadir Yıldız |
| author_sort | Serdar Akyel |
| collection | DOAJ |
| description | <b>Background</b>: Fractional Flow Reserve (FFR) is a method that enables the hemodynamic assessment of coronary artery stenosis. The Systemic Inflammatory Response Index (SIRI) is a new marker calculated by multiplying the neutrophil-to-lymphocyte ratio (NLR) with the monocyte count. It is indicative of the presence and severity of coronary artery disease. This study evaluates the relationship between the functional significance of FFR measurements and the SIRI in intermediate coronary stenosis. <b>Methods</b>: A total of 294 patients with 50–70% stenosis in their coronary arteries based on quantitative measurement following angiography who underwent FFR measurement were included in the study before the FFR procedure. Total and differential leukocyte counts and routine biochemical tests were performed. <b>Results</b>: A total of 37% of the patients were found to have a positive FFR, while 63% had a negative FFR. Significant differences were observed in the neutrophil count, monocyte count, Systemic Inflammation Response Index (SIRI), total cholesterol, and amount of adenosine used between the groups (<i>p</i> < 0.05). A SIRI value of 1.16 was 77% sensitive and 55% specific for FFR positivity. Multivariate logistic regression analysis identified the SIRI as an independent predictor of FFR positivity. <b>Conclusions</b>: Our study has demonstrated that high values of the SIRI may serve as a new biomarker for predicting FFR positivity. |
| format | Article |
| id | doaj-art-eced844a7e2b488e94ebe612b8d9ca48 |
| institution | Kabale University |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-eced844a7e2b488e94ebe612b8d9ca482025-01-24T13:28:57ZengMDPI AGDiagnostics2075-44182025-01-0115216210.3390/diagnostics15020162Assessment of the Severity of Intermediate Coronary Artery Stenosis Using the Systemic Inflammatory Response IndexSerdar Akyel0Ahmet Korkmaz1Abdülkadir Yıldız2Department of Cardiology, School of Medicine, Kastamonu University, Kastamonu 37150, TurkeyDepartment of Cardiology, Ankara City Hospital, Ankara 06200, TurkeyDepartment of Cardiology, School of Medicine, Kastamonu University, Kastamonu 37150, Turkey<b>Background</b>: Fractional Flow Reserve (FFR) is a method that enables the hemodynamic assessment of coronary artery stenosis. The Systemic Inflammatory Response Index (SIRI) is a new marker calculated by multiplying the neutrophil-to-lymphocyte ratio (NLR) with the monocyte count. It is indicative of the presence and severity of coronary artery disease. This study evaluates the relationship between the functional significance of FFR measurements and the SIRI in intermediate coronary stenosis. <b>Methods</b>: A total of 294 patients with 50–70% stenosis in their coronary arteries based on quantitative measurement following angiography who underwent FFR measurement were included in the study before the FFR procedure. Total and differential leukocyte counts and routine biochemical tests were performed. <b>Results</b>: A total of 37% of the patients were found to have a positive FFR, while 63% had a negative FFR. Significant differences were observed in the neutrophil count, monocyte count, Systemic Inflammation Response Index (SIRI), total cholesterol, and amount of adenosine used between the groups (<i>p</i> < 0.05). A SIRI value of 1.16 was 77% sensitive and 55% specific for FFR positivity. Multivariate logistic regression analysis identified the SIRI as an independent predictor of FFR positivity. <b>Conclusions</b>: Our study has demonstrated that high values of the SIRI may serve as a new biomarker for predicting FFR positivity.https://www.mdpi.com/2075-4418/15/2/162systemic inflammatory response index (SIRI)fractional flow reserve (FFR)coronary artery disease |
| spellingShingle | Serdar Akyel Ahmet Korkmaz Abdülkadir Yıldız Assessment of the Severity of Intermediate Coronary Artery Stenosis Using the Systemic Inflammatory Response Index Diagnostics systemic inflammatory response index (SIRI) fractional flow reserve (FFR) coronary artery disease |
| title | Assessment of the Severity of Intermediate Coronary Artery Stenosis Using the Systemic Inflammatory Response Index |
| title_full | Assessment of the Severity of Intermediate Coronary Artery Stenosis Using the Systemic Inflammatory Response Index |
| title_fullStr | Assessment of the Severity of Intermediate Coronary Artery Stenosis Using the Systemic Inflammatory Response Index |
| title_full_unstemmed | Assessment of the Severity of Intermediate Coronary Artery Stenosis Using the Systemic Inflammatory Response Index |
| title_short | Assessment of the Severity of Intermediate Coronary Artery Stenosis Using the Systemic Inflammatory Response Index |
| title_sort | assessment of the severity of intermediate coronary artery stenosis using the systemic inflammatory response index |
| topic | systemic inflammatory response index (SIRI) fractional flow reserve (FFR) coronary artery disease |
| url | https://www.mdpi.com/2075-4418/15/2/162 |
| work_keys_str_mv | AT serdarakyel assessmentoftheseverityofintermediatecoronaryarterystenosisusingthesystemicinflammatoryresponseindex AT ahmetkorkmaz assessmentoftheseverityofintermediatecoronaryarterystenosisusingthesystemicinflammatoryresponseindex AT abdulkadiryıldız assessmentoftheseverityofintermediatecoronaryarterystenosisusingthesystemicinflammatoryresponseindex |