Perforation of the descending colon induced by alectinib in a patient with non-small cell lung cancer: a Case Report
Anaplastic lymphoma kinase (ALK) inhibitor alectinib has demonstrated significant potential in treating non-small cell lung cancer (NSCLC); however, its adverse effects remain a notable challenge for healthcare professionals. This report examines the case of a 79-year-old female lung cancer patient...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1545614/full |
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| author | Yun Li Ping Yu Ran Wang |
| author_facet | Yun Li Ping Yu Ran Wang |
| author_sort | Yun Li |
| collection | DOAJ |
| description | Anaplastic lymphoma kinase (ALK) inhibitor alectinib has demonstrated significant potential in treating non-small cell lung cancer (NSCLC); however, its adverse effects remain a notable challenge for healthcare professionals. This report examines the case of a 79-year-old female lung cancer patient who presented with persistent colic in the left abdomen 10 months after initiating alectinib treatment. Upon admission, abdominal computed tomography revealed mild thickening of the descending colon wall, accompanied by free gas and surrounding exudation, leading to a diagnosis of descending colon perforation. After excluding alternative causes of gastrointestinal perforation, the condition was attributed to a severe adverse reaction associated with alectinib. While alectinib has been reported to cause serious gastrointestinal perforations, the underlying mechanism remains unclear and warrants further clinical investigation. Clinicians should be vigilant in recognizing and promptly managing this potential complication during alectinib therapy. |
| format | Article |
| id | doaj-art-ececfac183ce4df79cd94961a4f2e456 |
| institution | DOAJ |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-ececfac183ce4df79cd94961a4f2e4562025-08-20T03:13:39ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-05-011610.3389/fphar.2025.15456141545614Perforation of the descending colon induced by alectinib in a patient with non-small cell lung cancer: a Case ReportYun LiPing YuRan WangAnaplastic lymphoma kinase (ALK) inhibitor alectinib has demonstrated significant potential in treating non-small cell lung cancer (NSCLC); however, its adverse effects remain a notable challenge for healthcare professionals. This report examines the case of a 79-year-old female lung cancer patient who presented with persistent colic in the left abdomen 10 months after initiating alectinib treatment. Upon admission, abdominal computed tomography revealed mild thickening of the descending colon wall, accompanied by free gas and surrounding exudation, leading to a diagnosis of descending colon perforation. After excluding alternative causes of gastrointestinal perforation, the condition was attributed to a severe adverse reaction associated with alectinib. While alectinib has been reported to cause serious gastrointestinal perforations, the underlying mechanism remains unclear and warrants further clinical investigation. Clinicians should be vigilant in recognizing and promptly managing this potential complication during alectinib therapy.https://www.frontiersin.org/articles/10.3389/fphar.2025.1545614/fullALKnon-small cell lung canceralectinibadverse eventperforation of the descending colon |
| spellingShingle | Yun Li Ping Yu Ran Wang Perforation of the descending colon induced by alectinib in a patient with non-small cell lung cancer: a Case Report Frontiers in Pharmacology ALK non-small cell lung cancer alectinib adverse event perforation of the descending colon |
| title | Perforation of the descending colon induced by alectinib in a patient with non-small cell lung cancer: a Case Report |
| title_full | Perforation of the descending colon induced by alectinib in a patient with non-small cell lung cancer: a Case Report |
| title_fullStr | Perforation of the descending colon induced by alectinib in a patient with non-small cell lung cancer: a Case Report |
| title_full_unstemmed | Perforation of the descending colon induced by alectinib in a patient with non-small cell lung cancer: a Case Report |
| title_short | Perforation of the descending colon induced by alectinib in a patient with non-small cell lung cancer: a Case Report |
| title_sort | perforation of the descending colon induced by alectinib in a patient with non small cell lung cancer a case report |
| topic | ALK non-small cell lung cancer alectinib adverse event perforation of the descending colon |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1545614/full |
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