An Orthogonal Protection Strategy for the Synthesis of Conotoxins Containing Three Disulfide Bonds

An Orthogonal Protection Strategy for the Synthesis of Conotoxins Containing Three Disulfide Bonds

Disulfide bonds are crucial for stabilizing bioactive peptides such as conotoxins. We have developed a method for synthesizing conotoxins with three disulfide bonds using Mob, Trt, and Acm protection groups for regionally selective synthesis. This approach enabled the efficient synthesis of peptides...

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Bibliographic Details
Main Authors: Hengyu Zhang, Lai Yue Chan, Huanhuan Zhang, Tao Jiang, David J. Craik, Wenqing Cai, Rilei Yu
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Marine Drugs
Subjects:
orthogonal oxidation method
three disulfide bonds
conotoxins
Online Access:https://www.mdpi.com/1660-3397/23/4/168
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