The performance of artificial intelligence in image-based prediction of hematoma enlargement: a systematic review and meta-analysis
Background Accurately predicting hematoma enlargement (HE) is crucial for improving the prognosis of patients with cerebral haemorrhage. Artificial intelligence (AI) is a potentially reliable assistant for medical image recognition. This study systematically reviews medical imaging articles on the p...
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Taylor & Francis Group
2025-12-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2025.2515473 |
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| author | Wenjing Fan Zhiping Wu Wangyang Zhao Luzhu Jia Shuze Li Wei Wei Xin Chen |
| author_facet | Wenjing Fan Zhiping Wu Wangyang Zhao Luzhu Jia Shuze Li Wei Wei Xin Chen |
| author_sort | Wenjing Fan |
| collection | DOAJ |
| description | Background Accurately predicting hematoma enlargement (HE) is crucial for improving the prognosis of patients with cerebral haemorrhage. Artificial intelligence (AI) is a potentially reliable assistant for medical image recognition. This study systematically reviews medical imaging articles on the predictive performance of AI in HE.Materials and methods Retrieved relevant studies published before October, 2024 from Embase, Institute of Electrical and Electronics Engineers (IEEE), PubMed, Web of Science, and Cochrane Library databases. The diagnostic test of predicting hematoma enlargement based on CT image training artificial intelligence model, and reported 2 × 2 contingency tables or provided sensitivity (SE) and specificity (SP) for calculation. Two reviewers independently screened the retrieved citations and extracted data. The methodological quality of studies was assessed using the QUADAS-AI, and Preferred Reporting Items for Systematic reviews and Meta-Analyses was used to ensure standardised reporting of studies. Subgroup analysis was performed based on sample size, risk of bias, year of publication, ratio of training set to test set, and number of centres involved.Results 36 articles were included in this Systematic review to qualitative analysis, of which 23 have sufficient information for further quantitative analysis. Among these articles, there are a total of 7 articles used deep learning (DL) and 16 articles used machine learning (ML). The comprehensive SE and SP of ML are 78% (95% CI: 69–85%) and 85% (78–90%), respectively, while the AUC is 0.89 (0.86–0.91). The SE and SP of DL was 87% (95% CI: 80–92%) and 75% (67–81%), respectively, with an AUC of 0.88 (0.85–0.91). The subgroup analysis found that when the ratio of the training set to the test set is 7:3, the sensitivity is 0.77(0.62–0.91), p = 0.03; In terms of specificity, the group with sample size more than 200 has higher specificity, which is 0.83 (0.75–0.92), p = 0.02; among the risk groups in the study design, the specificity of the risk group was higher, which was 0.83 (0.76–0.89), p = 0.02. The group specificity of articles published before 2021 was higher, 0.84 (0.77–0.90); and the specificity of data from a single research centre was higher, which was 0.85 (0.80–0.91), p < 0.001.Conclusions Artificial intelligence algorithms based on imaging have shown good performance in predicting HE. |
| format | Article |
| id | doaj-art-ecc3713f6e38496697e4e3fd8daeae17 |
| institution | OA Journals |
| issn | 0785-3890 1365-2060 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
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| series | Annals of Medicine |
| spelling | doaj-art-ecc3713f6e38496697e4e3fd8daeae172025-08-20T02:09:12ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602025-12-0157110.1080/07853890.2025.2515473The performance of artificial intelligence in image-based prediction of hematoma enlargement: a systematic review and meta-analysisWenjing Fan0Zhiping Wu1Wangyang Zhao2Luzhu Jia3Shuze Li4Wei Wei5Xin Chen6Department of Epidemiology, School of Public Health, Dalian Medical University, Dalian, Liaoning, ChinaExperimental Teaching Center of Public Health, School of Public Health, Dalian Medical University, Dalian, Liaoning, ChinaDepartment of Epidemiology, School of Public Health, Dalian Medical University, Dalian, Liaoning, ChinaDepartment of Epidemiology, School of Public Health, Dalian Medical University, Dalian, Liaoning, ChinaDepartment of Epidemiology, School of Public Health, Dalian Medical University, Dalian, Liaoning, ChinaDepartment of Neurosurgery, Central hospital of Dalian University of Technology, Dalian, Liaoning, ChinaDepartment of Epidemiology, School of Public Health, Dalian Medical University, Dalian, Liaoning, ChinaBackground Accurately predicting hematoma enlargement (HE) is crucial for improving the prognosis of patients with cerebral haemorrhage. Artificial intelligence (AI) is a potentially reliable assistant for medical image recognition. This study systematically reviews medical imaging articles on the predictive performance of AI in HE.Materials and methods Retrieved relevant studies published before October, 2024 from Embase, Institute of Electrical and Electronics Engineers (IEEE), PubMed, Web of Science, and Cochrane Library databases. The diagnostic test of predicting hematoma enlargement based on CT image training artificial intelligence model, and reported 2 × 2 contingency tables or provided sensitivity (SE) and specificity (SP) for calculation. Two reviewers independently screened the retrieved citations and extracted data. The methodological quality of studies was assessed using the QUADAS-AI, and Preferred Reporting Items for Systematic reviews and Meta-Analyses was used to ensure standardised reporting of studies. Subgroup analysis was performed based on sample size, risk of bias, year of publication, ratio of training set to test set, and number of centres involved.Results 36 articles were included in this Systematic review to qualitative analysis, of which 23 have sufficient information for further quantitative analysis. Among these articles, there are a total of 7 articles used deep learning (DL) and 16 articles used machine learning (ML). The comprehensive SE and SP of ML are 78% (95% CI: 69–85%) and 85% (78–90%), respectively, while the AUC is 0.89 (0.86–0.91). The SE and SP of DL was 87% (95% CI: 80–92%) and 75% (67–81%), respectively, with an AUC of 0.88 (0.85–0.91). The subgroup analysis found that when the ratio of the training set to the test set is 7:3, the sensitivity is 0.77(0.62–0.91), p = 0.03; In terms of specificity, the group with sample size more than 200 has higher specificity, which is 0.83 (0.75–0.92), p = 0.02; among the risk groups in the study design, the specificity of the risk group was higher, which was 0.83 (0.76–0.89), p = 0.02. The group specificity of articles published before 2021 was higher, 0.84 (0.77–0.90); and the specificity of data from a single research centre was higher, which was 0.85 (0.80–0.91), p < 0.001.Conclusions Artificial intelligence algorithms based on imaging have shown good performance in predicting HE.https://www.tandfonline.com/doi/10.1080/07853890.2025.2515473Artificial intelligencemedical imagingmeta-analysishematoma expansionintracerebral hematoma |
| spellingShingle | Wenjing Fan Zhiping Wu Wangyang Zhao Luzhu Jia Shuze Li Wei Wei Xin Chen The performance of artificial intelligence in image-based prediction of hematoma enlargement: a systematic review and meta-analysis Annals of Medicine Artificial intelligence medical imaging meta-analysis hematoma expansion intracerebral hematoma |
| title | The performance of artificial intelligence in image-based prediction of hematoma enlargement: a systematic review and meta-analysis |
| title_full | The performance of artificial intelligence in image-based prediction of hematoma enlargement: a systematic review and meta-analysis |
| title_fullStr | The performance of artificial intelligence in image-based prediction of hematoma enlargement: a systematic review and meta-analysis |
| title_full_unstemmed | The performance of artificial intelligence in image-based prediction of hematoma enlargement: a systematic review and meta-analysis |
| title_short | The performance of artificial intelligence in image-based prediction of hematoma enlargement: a systematic review and meta-analysis |
| title_sort | performance of artificial intelligence in image based prediction of hematoma enlargement a systematic review and meta analysis |
| topic | Artificial intelligence medical imaging meta-analysis hematoma expansion intracerebral hematoma |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2025.2515473 |
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