Diethylene glycol monoethyl ether-mediated nanostructured lipid carriers enhance trans-ferulic acid delivery by Caco-2 cells superior to solid lipid nanoparticles
This work aimed to compare the performance of trans-ferulic acid-encapsulated nanostructured lipid carriers (NLCs) and solid lipid nanoparticles (SLNs) for transport by Caco-2 cells. The NLC particles (diameter: 102.6 nm) composed of Compritol® 888 ATO, ethyl oleate, Cremophor® EL, and Transcutol® P...
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| Format: | Article |
| Language: | English |
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Sciendo
2023-03-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2023-0009 |
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| _version_ | 1832545340721463296 |
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| author | Zhang Hongyu Guo Jingwen Wang Zhi Wang Na Feng Nianping Zhang Yongtai |
| author_facet | Zhang Hongyu Guo Jingwen Wang Zhi Wang Na Feng Nianping Zhang Yongtai |
| author_sort | Zhang Hongyu |
| collection | DOAJ |
| description | This work aimed to compare the performance of trans-ferulic acid-encapsulated nanostructured lipid carriers (NLCs) and solid lipid nanoparticles (SLNs) for transport by Caco-2 cells. The NLC particles (diameter: 102.6 nm) composed of Compritol® 888 ATO, ethyl oleate, Cremophor® EL, and Transcutol® P were larger than the SLNs (diameter: 86.0 nm) formed without liquid lipid (ethyl oleate), and the former had a higher encapsulation efficiency for trans-ferulic acid (p < 0.05). In vitro cultured Caco-2 cell transport was used to simulate intestinal absorption, and the cellular uptake of NLCs was higher than that of SLNs (p < 0.05). Compared to SLNs, NLCs greatly enhanced trans-ferulic acid permeation through the MillicellTM membrane (p < 0.05). This work confirms that NLCs have better properties than SLNs in terms of increasing drug transport by Caco-2 cells. This helps to comprehend the approach by which NLC-mediated oral bioavailability of trans-ferulic acid is better than that mediated by SLNs, as shown in our previous report. |
| format | Article |
| id | doaj-art-ecaeb03cabfe44cda1d2b41e13e98747 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2023-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-ecaeb03cabfe44cda1d2b41e13e987472025-02-03T07:26:17ZengSciendoActa Pharmaceutica1846-95582023-03-0173113314310.2478/acph-2023-0009Diethylene glycol monoethyl ether-mediated nanostructured lipid carriers enhance trans-ferulic acid delivery by Caco-2 cells superior to solid lipid nanoparticlesZhang Hongyu0Guo Jingwen1Wang Zhi2Wang Na3Feng Nianping4Zhang Yongtai5Department of Pharmaceutical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai201203ChinaDepartment of Pharmaceutical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai201203ChinaDepartment of Pharmaceutical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai201203ChinaDepartment of Pharmaceutical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai201203ChinaDepartment of Pharmaceutical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai201203ChinaDepartment of Pharmaceutical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai201203ChinaThis work aimed to compare the performance of trans-ferulic acid-encapsulated nanostructured lipid carriers (NLCs) and solid lipid nanoparticles (SLNs) for transport by Caco-2 cells. The NLC particles (diameter: 102.6 nm) composed of Compritol® 888 ATO, ethyl oleate, Cremophor® EL, and Transcutol® P were larger than the SLNs (diameter: 86.0 nm) formed without liquid lipid (ethyl oleate), and the former had a higher encapsulation efficiency for trans-ferulic acid (p < 0.05). In vitro cultured Caco-2 cell transport was used to simulate intestinal absorption, and the cellular uptake of NLCs was higher than that of SLNs (p < 0.05). Compared to SLNs, NLCs greatly enhanced trans-ferulic acid permeation through the MillicellTM membrane (p < 0.05). This work confirms that NLCs have better properties than SLNs in terms of increasing drug transport by Caco-2 cells. This helps to comprehend the approach by which NLC-mediated oral bioavailability of trans-ferulic acid is better than that mediated by SLNs, as shown in our previous report.https://doi.org/10.2478/acph-2023-0009solid lipid nanoparticlesnanostructured lipid carriersintestinal absorptioncaco-2 cellbioavailability |
| spellingShingle | Zhang Hongyu Guo Jingwen Wang Zhi Wang Na Feng Nianping Zhang Yongtai Diethylene glycol monoethyl ether-mediated nanostructured lipid carriers enhance trans-ferulic acid delivery by Caco-2 cells superior to solid lipid nanoparticles Acta Pharmaceutica solid lipid nanoparticles nanostructured lipid carriers intestinal absorption caco-2 cell bioavailability |
| title | Diethylene glycol monoethyl ether-mediated nanostructured lipid carriers enhance trans-ferulic acid delivery by Caco-2 cells superior to solid lipid nanoparticles |
| title_full | Diethylene glycol monoethyl ether-mediated nanostructured lipid carriers enhance trans-ferulic acid delivery by Caco-2 cells superior to solid lipid nanoparticles |
| title_fullStr | Diethylene glycol monoethyl ether-mediated nanostructured lipid carriers enhance trans-ferulic acid delivery by Caco-2 cells superior to solid lipid nanoparticles |
| title_full_unstemmed | Diethylene glycol monoethyl ether-mediated nanostructured lipid carriers enhance trans-ferulic acid delivery by Caco-2 cells superior to solid lipid nanoparticles |
| title_short | Diethylene glycol monoethyl ether-mediated nanostructured lipid carriers enhance trans-ferulic acid delivery by Caco-2 cells superior to solid lipid nanoparticles |
| title_sort | diethylene glycol monoethyl ether mediated nanostructured lipid carriers enhance trans ferulic acid delivery by caco 2 cells superior to solid lipid nanoparticles |
| topic | solid lipid nanoparticles nanostructured lipid carriers intestinal absorption caco-2 cell bioavailability |
| url | https://doi.org/10.2478/acph-2023-0009 |
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