Co-isolation of human donor eye cells and development of oncogene-mutated melanocytes to study uveal melanoma

Co-isolation of human donor eye cells and development of oncogene-mutated melanocytes to study uveal melanoma

Abstract Background Uveal melanoma (UM) is the most common intraocular tumor in adults, arises either de novo from normal choroidal melanocytes (NCMs) or from pre-existing nevi that stem from NCMs and are thought to harbor UM-initiating mutations, most commonly in GNAQ or GNA11. However, there are n...

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Main Authors: Yunxi Chen, Eva Jin, Mohamed Abdouh, Éric Bonneil, Daniel Alexander Jimenez Cruz, Thupten Tsering, Qianqian Zhou, Aurélie Fuentes-Rodriguez, Alexandra Bartolomucci, Alicia Goyeneche, Solange Landreville, Miguel N. Burnier, Julia V. Burnier
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Biology
Subjects:
Human donor eyes
In vitro models
Choroidal melanocytes
GNAQ mutation
Uveal melanoma
Proteomics
Online Access:https://doi.org/10.1186/s12915-025-02118-w
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https://doi.org/10.1186/s12915-025-02118-w

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