MOLECULAR PATHOGENESIS OF SECONDARY ACUTE PROMYELOCYTIC LEUKEMIA

MOLECULAR PATHOGENESIS OF SECONDARY ACUTE PROMYELOCYTIC LEUKEMIA

Balanced chromosomal translocations that generate chimeric oncoproteins are considered to be initiating lesions in the pathogenesis of acute myeloid leukemia. The most frequent is the t(15;17)(q22;q21), which fuses the PML and RARA genes, giving rise to acute promyelocytic leukemia (APL). An increas...

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Bibliographic Details
Main Authors:	Melanie Joannides, Ashley N Mays, Anita R Mistry, Syed Khizer Hasan, Andreas Reiter, Joseph L Wiemels, Carolyn A Felix, Francesco Lo-Coco, Neil Osheroff, Ellen Solomon, David Grimwade
Format:	Article
Language:	English
Published:	PAGEPress Publications 2011-10-01
Series:	Mediterranean Journal of Hematology and Infectious Diseases
Subjects:	Leukemia, therapy related leukemia, Acute promyelocytic leukemia
Online Access:	http://www.mjhid.org/index.php/mjhid/article/view/301
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