Sympathetic Renal Innervation and Resistant Hypertension
Hypertension in chronic renal disease and renovascular disease is often resistant to therapy. Understanding the pathogenic mechanisms responsible for hypertension in these conditions may lead to improved and more targeted therapeutic interventions. Several factors have been implicated in the pathoge...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.4061/2011/814354 |
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| _version_ | 1832548577506754560 |
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| author | Vito M. Campese Elaine Ku Jeanie Park |
| author_facet | Vito M. Campese Elaine Ku Jeanie Park |
| author_sort | Vito M. Campese |
| collection | DOAJ |
| description | Hypertension in chronic renal disease and renovascular disease is often resistant to therapy. Understanding the pathogenic mechanisms responsible for hypertension in these conditions may lead to improved and more targeted therapeutic interventions. Several factors have been implicated in the pathogenesis of hypertension associated with renal disease and/or renal failure. Although the role of sodium retention, total body volume expansion, and hyperactivity of the renin-angiotensin-aldosterone system (RAAS) are well recognized, increasing evidence suggests that afferent impulses from the injured kidney may increase sympathetic nervous system activity in areas of the brain involved in noradrenergic regulation of blood pressure and contribute to the development and maintenance of hypertension associated with kidney disease. Recognition of this important pathogenic factor suggests that antiadrenergic drugs should be an essential component to the management of hypertension in patients with kidney disease, particularly those who are resistant to other modalities of therapy. |
| format | Article |
| id | doaj-art-ec900d52de684362a1bf4e82c2faea9f |
| institution | Kabale University |
| issn | 2090-0392 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-ec900d52de684362a1bf4e82c2faea9f2025-02-03T06:13:51ZengWileyInternational Journal of Hypertension2090-03922011-01-01201110.4061/2011/814354814354Sympathetic Renal Innervation and Resistant HypertensionVito M. Campese0Elaine Ku1Jeanie Park2Division of Nephrology, USC/Keck School of Medicine, University of Southern California, 2020 Zonal Aveue, Los Angeles, CA 90033, USADivision of Nephrology, USC/Keck School of Medicine, University of Southern California, 2020 Zonal Aveue, Los Angeles, CA 90033, USARenal Division, Department of Medicine, Emory University, Atlanta, GA, USAHypertension in chronic renal disease and renovascular disease is often resistant to therapy. Understanding the pathogenic mechanisms responsible for hypertension in these conditions may lead to improved and more targeted therapeutic interventions. Several factors have been implicated in the pathogenesis of hypertension associated with renal disease and/or renal failure. Although the role of sodium retention, total body volume expansion, and hyperactivity of the renin-angiotensin-aldosterone system (RAAS) are well recognized, increasing evidence suggests that afferent impulses from the injured kidney may increase sympathetic nervous system activity in areas of the brain involved in noradrenergic regulation of blood pressure and contribute to the development and maintenance of hypertension associated with kidney disease. Recognition of this important pathogenic factor suggests that antiadrenergic drugs should be an essential component to the management of hypertension in patients with kidney disease, particularly those who are resistant to other modalities of therapy.http://dx.doi.org/10.4061/2011/814354 |
| spellingShingle | Vito M. Campese Elaine Ku Jeanie Park Sympathetic Renal Innervation and Resistant Hypertension International Journal of Hypertension |
| title | Sympathetic Renal Innervation and Resistant Hypertension |
| title_full | Sympathetic Renal Innervation and Resistant Hypertension |
| title_fullStr | Sympathetic Renal Innervation and Resistant Hypertension |
| title_full_unstemmed | Sympathetic Renal Innervation and Resistant Hypertension |
| title_short | Sympathetic Renal Innervation and Resistant Hypertension |
| title_sort | sympathetic renal innervation and resistant hypertension |
| url | http://dx.doi.org/10.4061/2011/814354 |
| work_keys_str_mv | AT vitomcampese sympatheticrenalinnervationandresistanthypertension AT elaineku sympatheticrenalinnervationandresistanthypertension AT jeaniepark sympatheticrenalinnervationandresistanthypertension |